EFFECTS OF GAMMA RAYS ON THE PHYSICAL STABILITY OF CARBOMERS AND CELLULOSE DERIVATIVES GEL BASES

Authors

  • Prasopchai Tonglairoum Department of Pharmaceutical Technology, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom
  • Tanasait Ngawhirunpat Department of Pharmaceutical Technology, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom
  • Praneet Opanasopit Department of Pharmaceutical Technology, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom
  • Suwannee Panomsuk Department of Pharmaceutical Technology, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom

DOI:

https://doi.org/10.14456/tbps.2017.12

Keywords:

gamma ray, gels, carbomer, methylcellulose, hydroxyethylcellulose, hydroxypropylcellulose

Abstract

This study was designed to investigate the effects of gamma rays on the physical stability of gel bases. The influences of amounts of gamma rays (0, 16.5 and 25 kGrays), gelling agents and gel concentrations were assessed. Five gelling agents (Carbomer 934, Carbomer 940, methylcellulose (MC), hydroxyethylcellulose (HEC) and hydroxypropylcellulose (HPC)) were employed in this study. The physical stability of the gel bases, before and after freeze-thaw cycle, was evaluated from the physical appearance,  viscosity and pH of the gel bases. The results revealed that the studied parameters of all gel bases changed after being exposed to the grammar ray. The higher the gamma rays used resulted in the lower viscosity of the gel bases. Gamma rays also had an effect on the viscosity of the gel bases after freeze-thaw cycle. Thus, the stability of the gel bases needs to be taken into account when using gamma rays as an alternative to sterilize or inhibit the microbial growth in gel bases.

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Published

2017-12-01

Issue

Vol. 12 No. 2 (2017): JULY - DECEMBER 2017

Section

Original Research Articles

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