BEYOND MEDICINE AVAILABILITY: UNPACKING THE CHALLENGES OF METHADONE MAINTENANCE THERAPY IMPLEMENTATION IN NORTHERN THAI HOSPITALS
DOI:
https://doi.org/10.69598/tbps.19.2.195-210Keywords:
methadone maintenance, opioid use disorder, complexity, NASSS framework, scale-up of innovationsAbstract
Methadone maintenance therapy (MMT) is a harm reduction-based approach that has been part of national policies since 2018. Despite its inception, MMT provision faces challenges, particularly in North Thailand, where opioid use disorders are the most prevalent. This study assessed MMT provisions in terms of system input, performance, and output in all 147 public hospitals under the Ministry of Public Health in Northern Thailand. This cross-sectional study employed an online questionnaire based on the World Health Organization’s six building blocks and the Non-adoption, Abandonment, Scale-up, Spread, and Sustainability (NASSS) framework. Northern Thailand data collection spanned from September 1, 2022, to February 1, 2023. The results revealed that ninety-eight hospitals (66.70%) responded. Only 37.76% actively provided MMT, 4.08% discontinued it, and 58.16% did not offer it. In areas where opioid overuse disorder is reported, MMT is available in 70.59% of the hospitals. The strong system governance and value proposition of MMT in hospitals with MMT services helped 78.49% of patients with opioid use disorder access services and maintained a one-year retention rate of 71.35%. Though patients with MMT services had a high retention rate, gaps still existed such as a lack of staff and training, limited data collection, and insufficient collaboration with stakeholders to expand the referral capacity. Inactive and pending hospitals lacked an MMT service policy, hindering service launches. According to the findings, the scaling up of MMT services still faces challenges, including the fact that most hospitals do not offer these services and even those that do often lack staff, training, and resources. Support for MMT services must be tailored to the specific needs and contexts of different hospitals.
References
United Nations Office on Drugs and Crime. World drug report 2020: Executive summary impact of COVID-19 policy implications [Internet]. 2020 [cited 2024 Aug 3]. Available from: https://reliefweb.int/report/world/unodc-world-drug-report-2020?gad_source=1&gclid=CjwKCAjwqre1BhAqEiwA7g9QhuPRhPgNW083IF3E2NtD9Vo9DGat-BhWkEUFAZzrqEF90_Di9POy-BoCztMQAvD_BwE
Office of the Secretary of National Addiction Treatment & Rehabilitation Committee, Ministry of Public Health. Drug Treatment Network [Internet]. 2021 [cited 2021 Aug 10]. Available from: https://antidrugnew.moph.go.th/Runtime/Runtime/Form/FrmPublicReport/ (in Thai)
Office of the Permanent Secretary, Ministry of Public Health. Guidelines for methadone maintenance therapy in Thailand. Bangkok: Chulalongkorn University Press; 2015. (in Thai)
Health Administration Division, Ministry of Public Health. Guide for the development of health service systems (Service Plan) for drug addiction. Samut Sakhon: Born to Be Publishing; 2018. (in Thai)
Ministry of Public Health. Key performance indicator of the Ministry of Public Health [Internet]. 2024 [cited 2024 Jun 24]. Available from: https://healthkpi.moph.go.th/kpi2/kpi-list/search/?KpiListSearch%5Btitle%5D=retention (in Thai)
Health KPI, Ministry of Public Health. Percent of addictive substance patients receive treatment and continuous follow-up care in 1 year (retention rate) [Internet]. 2024 [cited 2024 Jun 24]. Available from: https://healthkpi.moph.go.th/kpi2/kpi/index/?id=1623 (in Thai)
Cernasev A, Hohmeier KC, Frederick K, Jasmin H, Gatwood J. A systematic literature review of patient perspectives of barriers and facilitators to access, adherence, stigma, and persistence to treatment for substance use disorder. Explor Res Clin Soc Pharm. 2021;2:100029.
Lin C, Lan C-W, Li L, Rou K. Service providers’ adherence to methadone maintenance treatment protocol in China. Int J Drug Policy. 2018;56:1-5.
Yin W, Hao Y, Sun X, Gong X, Li F, Li J, et al. Scaling up the national methadone maintenance treatment program in China: Achievements and challenges. Int J Epidemiol. 2010;39(Suppl 2):ii29-37.
Khazaee-Pool M, Moeeni M, Ponnet K, Fallahi A, Jahangiri L, Pashaei T. Perceived barriers to methadone maintenance treatment among Iranian opioid users. Int J Equity Health. 2018;17(1):75.
Cioe K, Biondi BE, Easly R, Simard A, Zheng X, Springer SA. A systematic review of patients’ and providers’ perspectives of medications for treatment of opioid use disorder. J Subst Abuse Treat. 2020;1(119):108-46.
Kermode M, Choudhurimayum RS, Rajkumar LS, Haregu T, Armstrong G. Retention and outcomes for clients attending a methadone clinic in a resource-constrained setting: A mixed methods prospective cohort study in Imphal, Northeast India. Harm Reduct J. 2020;17(1):68.
Wu F, Peng C-Y, Jiang H, Zhang R, Zhao M, Li J, et al. Methadone maintenance treatment in China: Perceived challenges from the perspectives of service providers and patients. J Public Health. 2013;35(2):206-12.
Hayashi K, Ti L, Ayutthaya PPN, Suwannawong P, Kaplan K, Small W, et al. Barriers to retention in methadone maintenance therapy among people who inject drugs in Bangkok, Thailand: A mixed methods study. Harm Reduct J. 2017;14(63):1-8.
Lin C, Wu Z, Rou K, Pang L, Cao X, Shoptaw S, et al. Challenges in providing services in methadone maintenance therapy clinics in China: Service providers’ perceptions. Int J Drug Policy. 2010;21(3):173-8.
Nimsakul K, Suwannaprom P, Suttajit S. Complexity of implementing Harm Reduction Services in community hospitals: A two-phase qualitative study. TJPS. 2022;46(3):324-34.
Ratliff EA, Kaduri P, Masao F, Mbwambo JKK, McCurdy SA. Harm reduction as a complex adaptive system: A dynamic framework for analyzing Tanzanian policies concerning heroin use. Int J Drug Policy. 2016;30:7-16.
Greenhalgh T, Wherton J, Papoutsi C, Lynch J, Hughes G, A’Court C, et al. Analysing the role of complexity in explaining the fortunes of technology programmes: Empirical application of the NASSS framework. BMC Med 2018;16(1):66.
Greenhalgh T, Wherton J, Papoutsi C, Lynch J, Hughes G, A’Court C, et al. Beyond adoption: A new framework for theorizing and evaluating nonadoption, abandonment, and challenges to the scale-up, spread, and sustainability of health and care technologies. J Med Internet Res. 2017;19(11):e367.
Horton TJ, Illingworth JH, Warburton WHP. Overcoming challenges in codifying and replicating complex health care interventions. Health Aff (Millwood). 2018;37(2):191-7.
Pype P, Mertens F, Helewaut F, Krystallidou D. Healthcare teams as complex adaptive systems: Understanding team behaviour through team members’ perception of interpersonal interaction. BMC Health Serv Res. 2018;18(1):570.
James HM, Papoutsi C, Wherton J, Greenhalgh T, Shaw SE. Spread, scale-up, and sustainability of video consulting in health care: Systematic review and synthesis guided by the NASSS framework. J Med Internet Res. 2021;23(1):e23775.
Abimbola S, Patel B, Peiris D, Patel A, Harris M, Usherwood T, et al. The NASSS framework for ex post theorisation of technology-supported change in healthcare: Worked example of the TORPEDO programme. BMC Medicine. 2019;17(1):233.
World Health Organization. Everybody business: In strengthening health systems to improve health outcomes: WHO’s framework for action. Geneva: World Health Organization WHO; 2007.
Marshall K, Maina G, Sherstobitoff J. Plausibility of patient-centred care in high-intensity methadone treatment: reflections of providers and patients. Addict Sci Clin Pract. 2021;16(1):42.
Trujols J, Siñol N, Iraurgi I, Batlle F, Guàrdia J, Cobos JPdl. Patient and clinician’s ratings of improvement in methadone-maintained patients: Differing perspectives? Harm Reduct J. 2011;8:23.
Krawczyk N, Rivera BD, Levin E, Dooling BCE. Synthesising evidence of the effects of COVID-19 regulatory changes on methadone treatment for opioid use disorder: implications for policy. Lancet Public Health. 2023;8(3):e238-46.
Suen LW, Castellanos S, Joshi N, Satterwhite S, Knight KR. “The idea is to help people achieve greater success and liberty”: A qualitative study of expanded methadone take-home access in opioid use disorder treatment. Subst Abus 2022;43(1):1147–54.
Sooktong K, Suttajit S, Suwannaprom P. Challenges, adaptations, and preparedness for challenges in methadone maintenance therapy by hospitals in health regions 1 and 2. TJPP 2025;2:1-21.
Xiao L, Wu Z, Luo W, Wei X. Quality of life of outpatients in methadone maintenance treatment clinics. J Acquir Immune Defic Syndr. 2010;53(Suppl 1):S116-20.
Nemeth C, Wears R, Woods D, Hollnagel E, Cook R. Minding the gaps: creating resilience in health care. AHRQ. 2008:3.
Philbin MM, Zhang F. Exploring stakeholder perceptions of facilitators and barriers to accessing methadone maintenance clinics in Yunnan Province, China. AIDS Care. 2010;22(5):623-9.
Tantivess S, Pumtong S, Suwannaprom P, Suttajit S, Jitraknatee A. Determination of research direction/questions to inform the introduction of the National Drug System Development Strategy. Nonthaburi: HSRI; 2022.
Hatch-Maillette MA, Peavy KM, Tsui JI, Banta-Green CJ, Woolworth S, Grekin P. Re-thinking patient stability for methadone in opioid treatment programs during a global pandemic: Provider perspectives. J Subst Abuse Treat. 2021;124:108223.
Hunter SB, Dopp AR, Ober AJ, Uscher-Pines L. Clinician perspectives on methadone service delivery and the use of telemedicine during the COVID-19 pandemic: A qualitative study. J Subst Abuse Treat. 2021;124:108288.
Trujols J, Larrabeiti A, Sànchez O, Madrid M, Andrés SD, Duran-Sindreu S. Increased flexibility in methadone take-home scheduling during the COVID-19 pandemic: Should this practice be incorporated into routine clinical care? J Subst Abuse Treat. 2020;119:108154.
Levander XA, Hoffman KA, McIlveen JW, McCarty D, Terashima JP, Korthuis PT. Rural opioid treatment program patient perspectives on take-home methadone policy changes during COVID-19: A qualitative thematic analysis. Addict Sci Clin Pract 2021;16(1):72.
Suen L, Nguyen O, Knight K. Learning from COVID-19: How pandemic-era policies for methadone prescribing could improve opioid treatment. California Health Care Foundation [Internet]. 2022 [cited 2024 Aug 3]. Available from: https://www.chcf.org/publication/learning-covid-19-pandemic-era-policies-methadone-prescribing-improve-opioid-treatment/
Lin C, Tuan NA, Li L. Commune health workers’ methadone maintenance treatment (MMT) knowledge and perceived difficulties providing decentralized MMT services in Vietnam. Subst Use Misuse. 2018;53(2):194-9.
Chen J, Lin C, Cao W, Wu Z, Li L. Turnover intention among service providers in Chinese methadone maintenance treatment clinics. J Public Health. 2019;29(3):979-84.
Eby LT, Burk H, Maher CP. How serious of a problem is staff turnover in substance abuse treatment? A longitudinal study of actual turnover. J Subst Abuse Treat. 2010;39(3):264-71.
Andrews S, Sorensen JL, Guydish J, Delucchi K, Greenberg B. Knowledge and attitudes about methadone maintenance among staff working in a therapeutic community. J Maint Addict. 2005;3(1):47-59.
Calcaterra S, Bach P, Chadi A, Chadi N, Kimmel S, Morford K, et al. Methadone matters: What the United States can learn from the global effort to treat opioid addiction. J Gen Intern Med. 2019;34(6):1039-42.
Deren S, Kang S-Y, Mino M, Seewald RM. Attitudes of methadone program staff toward provision of harm-reduction and other services. J Addict Med. 2012;5(4):289-92.
Dooley J, Asbridge M, Fraser J, Kirkland S. Physicians’ attitudes towards office-based delivery of methadone maintenance therapy: Results from a cross-sectional survey of Nova Scotia primary-care physicians. Harm Reduct J. 2012;13(9):20.
Luo S, Lin C, Feng N, Wu Z, Li L. Stigma towards people who use drugs: A case vignette study in methadone maintenance treatment clinics in China. Int J Drug Policy. 2019;71:73-7.
Watson T, Hughes C. Pharmacists and harm reduction: A review of current practices and attitudes. Can Pharm J (Ott). 2012;145(3):124-7.
Caplehorn JRM, Lumley TS, lrwig L, Saunders JB. Changing attitudes and beliefs of staff working in methadone maintenance programs. Aust NZ J Public Health. 1998;22(4):505-8.
Hohmeier KC, Cernasev A, Sensmeier M, Hall E, Webb K, Barenie R, Cochran G. U.S. student pharmacist perceptions of the pharmacist’s role in methadone for opioid use disorder: A qualitative study. SAGE Open Med. 2021;3(9):20503121211022994.
Thomas S, Sagan A, Larkin J, Cylus J, Figueras J, Karanikolos M. Strengthening health systems resilience: Key concepts and strategies [Internet]. 2020 [cited 2024 Aug 3]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK559803/
Witter S, Thomas S, Topp SM, Barasa E, Chopra M, Cobos D, et al. Health system resilience: A critical review and reconceptualisation. Lancet Glob Health. 2023;11:e1454-8.
Shidlansik L, Adelson M, Peles E. Knowledge and stigma regarding methadone maintenance treatment among personnel of methadone maintenance treatment and non-methadone maintenance treatment addiction facilities in Israel. J Addict Dis. 2017;36(1):30-7.
Sarasvita R, Tonkin A, Utomo B, Ali R. Predictive factors for treatment retention in methadone programs in Indonesia. J Subst Abuse Treat. 2012;42(3):239-46.
Deck D, Carlson MJ. Access to publicly funded methadone maintenance treatment in two western states. J Behav Health Serv Res. 2004;31(2):164-77.
Government of Canada. Archived literature review methadone maintenance treatment [Internet]. 2002 [cited 2024 Jun 24]. Available from: https://www.canada.ca/en/health-canada/services/health-concerns/reports-publications/alcohol-drug-prevention/literature-review-methadone-maintenance-treatment.html
Tejativaddhana P, Briggs D, Singhadej O, Hinoguin R. Developing primary health care in Thailand: Innovation in the use of socio-economic determinants, Sustainable Development Goals and the district health strategy. Public Admin Policy. 2018;21(1):36-49.
Adeniran E, Quinn M, Wallace R, Walden RR, Labisi T, Olaniyan A, et al. A scoping review of barriers and facilitators to the integration of substance use treatment services into US mainstream health care. Drug Alcohol Depend Rep. 2023;7:100152.
Boontanon N, Sonsri G. District-level collaboration for improving quality of life of older people in Thailand. Lex Localis - J Local Self Gov 2023;21(4):937-58.
Nuntaboot K, Boonsawasdgulchai P, Bubpa N. Roles of mutual help of local community networks in community health activities: Improvement for the quality of life of older people in Thailand. Int J Nurs Sci 2019;12(3):266-71.
Somsida S, Kowit S. The people’s participation in drug prevention in arge of Suan Yai subdistrict, Muang district, Nonthaburi province. J Dev Admin Res 2020;10(2):91-7. (in Thai)
Downloads
Published
How to Cite
Issue
Section
License
All articles published and information contained in this journal such as text, graphics, logos and images is copyrighted by and proprietary to the Thai Bulletin of Pharmaceutical Sciences, and may not be reproduced in whole or in part by persons, organizations, or corporations other than the Thai Bulletin of Pharmaceutical Sciences and the authors without prior written permission.