DEVELOPMENT OF FLUCONAZOLE-LOADED POLY(VINYL ALCOHOL)/POLY(ETHYLENE GLYCOL) BLENDED FILM FOR TREATMENT OF CANDIDA-INFECTED CUTANEOUS WOUNDS

Authors

  • Peerapat Chidchai Pharmaceutical Development of Green Innovations Group (PDGIG), Faculty of Pharmacy, Silpakorn University, Nakhon Pathom
  • Worranan Rangsimawong Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmaceutical Sciences, Ubon Ratchathani University, Ubon Ratchathani
  • Praneet Opanasopit Department of Industrial Pharmacy, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom
  • Prasopchai Patrojanasophon Department of Industrial Pharmacy, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom
  • Chaiyakarn Pornpitchanarong Department of Industrial Pharmacy, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom
  • Prin Chaksmithanont Department of Industrial Pharmacy, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom

DOI:

https://doi.org/10.69598/tbps.19.2.221-229

Keywords:

fluconazole, poly(vinyl alcohol), poly(ethylene glycol), films, candidiasis

Abstract

In this work, we aimed to develop fluconazole (FLU)-loaded polymer blended film (FLU-film) for candidiasis wounds. The films were prepared from poly(vinyl alcohol) (PVA) and poly(ethylene glycol) 1000 (PEG 1000) mixed at different proportions by weight, casted on a petri dish, and dried at 60ºC for 12 h. Tensile strength, swelling ratio, and morphology were analyzed to determine an appropriate film for wound application. The selected film was loaded with 0.5% w/w FLU, where the drug homogeneity was ascertained. Then, the drug release profile, cytotoxicity of the films, and antifungal activity were determined. The findings revealed that the suitable film was PVA:PEG 1000 (95:5), showing anticipated flexibility and stretchability, as well as a soothing texture, while the swelling and molecular attributes were comparable to other films. FLU was homogenously loaded into the selected film and presented a prolonged release profile following Higuchi’s model. The film was found to be non-toxic to the human skin fibroblast. Lastly, the FLU-film presented 1.16-fold greater antifungal effectiveness than the free FLU. Overall, the FLU-film has been developed and proven to be effective for treating Candida-infected wounds.

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Published

2024-09-19

How to Cite

Chidchai, P., Rangsimawong, W. ., Opanasopit, P. ., Patrojanasophon, P. ., Pornpitchanarong, C., & Chaksmithanont, P. . (2024). DEVELOPMENT OF FLUCONAZOLE-LOADED POLY(VINYL ALCOHOL)/POLY(ETHYLENE GLYCOL) BLENDED FILM FOR TREATMENT OF CANDIDA-INFECTED CUTANEOUS WOUNDS . Thai Bulletin of Pharmaceutical Sciences, 19(2), 221–229. https://doi.org/10.69598/tbps.19.2.221-229

Issue

Vol. 19 No. 2 (2024): JULY-DECEMBER 2024 (In Progress)

Section

Original Research Articles

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