พันธุศาสตร์เชิงเคมี: องค์ความรู้ทางเคมีสู่ศักราชใหม่แห่งการวิจัยทางพันธุศาสตร์ (Chemical genetics: Entering the new era of genetics research with chemistry)
DOI:
https://doi.org/10.14456/tjg.2014.7Keywords:
chemical genetics, chemical biology, antimalarial, protein-protein interactionAbstract
การวิจัยและค้นหาองค์ความรู้ใหม่ทางวิทยาศาสตร์ที่เป็นการเชื่อมโยงศาสตร์พื้นฐาน เช่น ชีววิทยาและเคมี กำลังเป็นที่สนใจอย่างมากในปัจจุบัน ซึ่งศาสตร์หนึ่งที่ได้รับประโยชน์โดยตรงจากการนำองค์ความรู้และเทคนิควิธีการทางเคมีมาใช้ ได้แก่ พันธุศาสตร์เชิงเคมี โดยศาสตร์นี้พัฒนาขึ้นเพื่อศึกษาพันธุศาสตร์ในบางประเด็นซึ่งเทคนิคแบบดั้งเดิมไม่สามารถกระทำได้ ดังนั้นการประยุกต์ใช้ทั้งพันธุศาสตร์แบบดั้งเดิมและเชิงเคมีร่วมกันย่อมจะนำไปสู่การสังเคราะห์องค์ความรู้เกี่ยวกับกระบวนการพื้นฐานในสิ่งมีชีวิตต่างๆ ได้เป็นอย่างดี นอกจากนี้ พันธุศาสตร์เชิงเคมียังมีศักยภาพที่จะนำไปสู่การพัฒนายารักษาโรคในรูปแบบใหม่ได้อีกด้วย เช่น การค้นหาสารประกอบที่ยับยั้งอันตรกิริยาระหว่างโปรตีนใน human papillomavirus และการค้นหาสารออกฤทธิ์ต้านเชื้อมาลาเรีย
Research at the interface of chemistry and biology has recently gained increasing interest from the scientific communities. One of the most active fields in this research theme is chemical genetics, a study aimed to utilize chemical tools and knowledge to study genetics in certain ways that traditional methods cannot offer. Combining the power of traditional genetics and chemical genetics will no doubt pave the way to new insights in the fundamental processes of living organisms. Furthermore, chemical genetics can have an impact in discovering new drugs with novel modes of actions. Two examples including the development of inhibitors for protein-protein interaction in human papillomavirus and the development of novel antimalarial agents are highlighted.
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