ฐานข้อมูลความหลากหลายทางพันธุกรรมในคนไทยแบบสนิปและซีเอ็นวี
DOI:
https://doi.org/10.14456/tjg.2010.9Keywords:
SNPs, CNV, Thais, Genetic polymorphismAbstract
The determination of association between single nucleotide polymorphisms (SNPs) and copy number variations (CNV) and the risks of development of diseases will be useful in development of predictive system based on genetic makeup of individual. Moreover, such polymorphisms can also be used in refining the efficacy and safety of drugs which are different amongst people. To identify genetic risks of common diseases, the information of linkage disequilibrium patterns in the study population is needed for estimation of sample sizes and averting genotyping of non-polymorphic markers in the study population. This information will particularly be very important for genotype-phenotype association. This project aims to determine SNPs and CNVs in Thai population by using 5th generation Affymetrix SNP genotyping arrays, each array contains approximately 500,000 known SNP genotyping positions. Furthermore, this analysis offers genetic comparative analysis of Thais against other NCBI dbSNP, Pan-Asian SNP Database, International HapMap Project, JSNP and Database of Genomic Variant. The genotypic information is made available for public access at http://www.biotec.or.th/thaisnp2.
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