Cancer: secret in genetic code
DOI:
https://doi.org/10.14456/tjg.2012.15Keywords:
cancer, risk factor, DNA and chromosome, mutation, epigeneticsAbstract
Cancer is the cause of death in the early days of mankind, results from abnormality of cell growth. The causes of this abnormality are both environmental and genetics leading to DNA damage, mutation and cancer cells, eventually. Cancer genes can be categorized into 3 groups; oncogenes, tumor suppressor genes and DNA mismatch repair genes. Not only mutation of these 3 groups is observed but also epigenetic abnormality is considered for the cause of cancer. However, cancer is not single gene disorder. It has multistep process for tumorigenesis. There is accumulation of several genes mutation for a long time of cancer development. Nowadays, pharmacogenetics has been used in cancer therapy. For example, drug therapy for EGFR mutation has been used for lung cancer patients. Taken together, genetic study is the useful basic research for clinical development and quality of life in human being.References
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