ไมโครอาร์เอ็นเอ: การประยุกต์ใช้สำหรับนิติวิทยาศาสตร์ (miRNA: applications of forensic science)
DOI:
https://doi.org/10.14456/tjg.2015.8Keywords:
ไมโครอาร์เอ็นเอ (MicroRNAs), การระบุชนิดของเหลวจากร่างกาย (Body fluid identification), เวลาหลังเสียชีวิต (Postmortem interval), การฆ่าตัวตาย (Suicide), นิติวิทยาศาสตร์ (Forensic science)Abstract
MicroRNA (miRNA) is small non-coding RNA with a length of 18 to 25 nucleotides. miRNA plays an essential role in regulating gene expression at the post-transcriptional level. At present, the functional roles of miRNA have been extensively studied, especially in medical science. In addition, applications of miRNA have expanded to include forensic science. This review highlights recent findings in applications of miRNA in forensic science, especially in body fluid identification, postmortem interval estimation and identification of manner of death.
MicroRNAs (miRNAs) เป็นอาร์เอ็นเอที่อยู่ในกลุ่ม non-coding RNA โดย miRNAs เป็นอาร์เอ็นเอขนาดเล็กมีความยาวประมาณ 18-25 นิวคลิโอไทด์ ทำหน้าที่สำคัญในกระบวนการควบคุมการแสดงออกของยีน โดยมีหน้าที่ควบคุมระดับของ mRNA ภายในเซลล์ บทบาทของ miRNAs ได้ถูกศึกษาอย่างแพร่หลายโดยเฉพาะอย่างยิ่งในทางวิทยาศาสตร์การแพทย์ นอกจากนี้ในปัจจุบัน miRNAs ยังถูกนำมาศึกษาเพื่อหาแนวทางประยุกต์ใช้งานในด้านนิติวิทยาศาสตร์อีกด้วย บททบทวนวรรณกรรมเรื่องนี้จะแสดงให้เห็นถึงความเป็นไปได้ในการใช้ miRNAs ในงานด้านนิติวิทยาศาสตร์ เช่น การระบุชนิดของเหลวจากร่างกาย การประมาณระยะเวลาหลังเสียชีวิต และการระบุพฤติกรรมในการเสียชีวิตจากการฆ่าตัวตาย
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