Association between Lesions of Cancer and Survival of Colorectal Cancer (CRC) Patients after Diagnosis at Maharat Nakhon Ratchasima Hospital, Nakhon Ratchasima Province
Keywords:
Colorectal cancer; Cancer lesion; Survival rate; Cancer registryAbstract
Background and Objective: In previous studies there were conversely in survival rate of the sides of colorectal cancer (CRC). Differences in the survival rate for CRC have been observed among the left-sided and right-sided tumors, with further regional variation. There was inconsistency in survival rate varies by regions. The objective of this study was to compare the survival rate between left and right-sided tumors after diagnosis of CRC patients at Maharat Nakhon Ratchasima hospital, Nakhon Ratchasima province.
Methods: Data (2,096 cases) were collected from the Maharat Nakhon Ratchasima hospital-based cancer registry (2014-2018) in Nakhon Ratchasima province. The survival rate was estimated using the Kaplan-Meier method. Between group compassions were made using the Log rank test. We reported the median survival time and 95% confidence interval.
Result: Of 2,096 CRC patients, 1,209 died during the study period, corresponding to a case-fatality rate of 31.4 per 100 person-years (95%CI: 29.6-33.1). The median survival time was 1.95 years. (95%CI: 1.77-2.12). The overall survival rates at 1, 3, and 5 years were 66.6% (95%CI: 64.5-68.5), 39.3% (95%CI; 37.0-41.5), and 30.3% (95%CI; 27.7-32.8), respectively. The survival rate between the left and right-sided tumors was not significantly different (Log rank test = 0.59, p=0.444).
Conclusion: The survival rate between right- and left-sided CRC lesions was not significantly different. The 5-year survival rate is poor; consequently, primary prevention is crucial and screening for early detection is necessary to improve survival rate. Further research should focus on the factors affecting survival of CRC.
References
2. Imsamran W, Pattatang A, Supaattagorn P, Chiawiriyabunya I, Namthaisong K, Wongsena M, et al. Cancer in Thailand vol. IX, 2013-2015. Bangkok: New Thammada Press (Thailand) Co., Ltd. 202 Soi Charoenkrung 57, Yannawa, Sathorn, Bangkok 10120 Thailand, 2018.
3. Shida D, Tanabe T, Boku N, Takashima A, Yoshida T, Tsukamoto S, et al. Prognostic value of primary tumor sidedness for unresectable stage IV colorectal cancer: a retrospective study. Ann Surg Oncol 2019; 26 :1358–1365.
4. 4. Norén A, Eriksson HG, Olsson LI. Selection for surgery and survival of synchronous colorectal liver metastases; a nationwide study. Eur J Cancer 2016; 53:105–114.
5. ภานุพล พงษ์ธนู, สุพรรณี พรหมเทศ, กฤติกา สุวรรณรุ่งเรือง, อัตรารอดชีพของผู้ป่วยมะเร็งลำไส้ใหญ่ในประชากรจังหวัดขอนแก่น.วารสารโรงพยาบาลสกลนคร 2559; 2: 243-251.
6. นันทิพัฒน์ พัฒนโชติ, เกรียงไกร โกวิทางกูร, ณรงค์ชัย สังซา, ชิตเขต โตเหมือน, วงษ์กลาง กุดวงษา, พงษ์เดช สารการ และคณะ. การเปรียบเทียบอัตรารอดชีพผู้ป่วยโรคมะเร็งลำไส้ใหญ่ระยะที่ 2 และ3 หลังได้รับการรักษาด้วยการผ่าตัด. ศรีนครินทร์เวชสาร 2560; 32: 584-90
7. Moghimi-Dehkordi B, Safaee A, Zali M. Comparison of colorectal and gastric cancer: survival and prognostic factors. Saudi J Gastroenterol 2009; 15: 18-23.
8. 8. Rasouli MA, Moradi G, Roshani D, Nikkhoo B, Ghaderi E, Ghaytasi B, et al. Prognostic factors and survival of colorectal cancer in Kurdistan province, Iran: A population-based study (2009–2014). Medicine 2017; 96: 294-300.
9. Zhang S, Gao F, Luo J, Yang J. Prognostic factors in survival of colorectal cancer patients with synchronous liver metastasis: Factor in survival of colorectal cancer with liver metastasis. Colorectal Dis 2009; 12: 754–761.
