Prevalence and Risk Factors of Erectile Dysfunction in Systemic Sclerosis

Main Article Content

Kittikorn Duangkum
Kusuman Sriphuwong
Pimchanok Tantiwong
Thida Phungtaharn

Abstract

Background and Objective: Systemic sclerosis (SSc) is a systemic autoimmune disease which associate with erectile dysfunction (ED). However, there was no previous study in Thailand. This research aimed to study the prevalence and risk factors of ED in SSc patients.


Methods : A cross-sectional analytical research to explore the prevalence and risk factors of ED in SSc patients at the outpatient department of Khon Kaen Hospital during 2nd May 2017 – 31st May 2018 using the International Index of Erectile Function-5 (IIEF-5) questionnaire.


Results : A total of 59 male participants found that 93.22% had ED and did not attempt intercourse. A 45.76% did not attempt intercourse. In the sexually active group 32 men, the prevalence of ED was 87.5% (95% CI, 71.01-96.49) which 43.75% were severe ED, 3.13% were moderate ED, 12.5% were mild to moderate ED, 28.12% had mild ED, while only 12.5% had no ED. Risk factor of ED is diffuse cutaneous systemic sclerosis (dcSSc) with Odds ratio 10.57 (95%CI, 1.08-103.59, p= 0.043).


Conclusions :  The majority of male SSc patients had ED and did not attempt intercourse. The significant risk factor is dcSSc.

Downloads

Download data is not yet available.

Article Details

How to Cite
1.
Duangkum K, Sriphuwong K, Tantiwong P, Phungtaharn T. Prevalence and Risk Factors of Erectile Dysfunction in Systemic Sclerosis. SRIMEDJ [Internet]. 2021 Aug. 20 [cited 2023 Feb. 5];36(4):409-15. Available from: https://li01.tci-thaijo.org/index.php/SRIMEDJ/article/view/251813
Section
Original Articles

References

1. LeRoy EC, Black C, Fleischmajer R, Jablonska S, Krieg T, Medsger TA, et al. Scleroderma (systemic sclerosis): classification, subsets and pathogenesis. J Rheumatol 1988; 15(2): 202–205.
2. Lally EV, Jimenez SA. Impotence in progressively systemic sclerosis. Ann Intern Med 1981; 95(2): 150–153.
3. Nowlin NS, Brick JE, Weaver DJ, Wilson DA, Judd HL, Lu JKH, et al. Impotence in Scleroderma. Ann Intern Med 1986; 104(6): 794–798.
4. Hong P, Pope JE, Ouimet JM, Rullan E, Seibold JR. Erectile dysfunction associated with scleroderma: a case-control study of men with scleroderma and rheumatoid arthritis. The Journal of Rheumatology 2004; 31(3): 508–513.
5. Foocharoen C, Tyndall A, Hachulla E, Rosato E, Allanore Y, Farge-Bancel D, et al. Erectile dysfunction is frequent in systemic sclerosis and associated with severe disease: a study of the EULAR Scleroderma Trial and Research group. Arthritis Res Ther 2012; 14(1): R37.
6. Herrick A. Diagnosis and management of scleroderma peripheral vascular disease. Rheum Dis Clin North Am 2008; 34(1): 89–114; vii.
7. Rosen RC, Riley A, Wagner G, Osterloh IH, Kirkpatrick J, Mishra A. The international index of erectile function (IIEF): a multidimensional scale for assessment of erectile dysfunction. Urology 1997; 49(6): 822–830.
8. Rosen RC, Cappelleri JC, Smith MD, Lipsky J, Peña BM. Development and evaluation of an abridged, 5-item version of the International Index of Erectile Function (IIEF-5) as a diagnostic tool for erectile dysfunction. Int J Impot Res 1999; 11(6): 319–326.
9. Masi AT. Preliminary criteria for the classification of systemic sclerosis (scleroderma). Arthritis & Rheumatism 1980; 23(5): 581–590.
10. van den Hoogen F, Khanna D, Fransen J, Johnson SR, Baron M, Tyndall A, et al. 2013 classification criteria for systemic sclerosis: an American college of rheumatology/European league against rheumatism collaborative initiative. Ann Rheum Dis 2013; 72(11): 1747–1755.
11. Enderlein G. Daniel, Wayne W. Biostatistics — A Foundations for Analysis in the Health Sciences. Wiley & Sons, New York—Chichester—Brisbane—Toronto—Singapore, 6th ed. 1995, 780 S., £58.—, ISBN 0–471–58852-0 (cloth). Biometrical Journal 1995; 37(6): 744–744.
12. Rosen RC, Cappelleri JC, Gendrano N. The International Index of Erectile Function (IIEF): a state-of-the-science review. Int J Impot Res 2002; 14(4): 226–244.
13. Sangkum P, Sukying C, Viseshsindh W, Kochakarn W, Patcharatrakul S, Khongcharoensombat W. Validation and Reliability of a Thai Version of the International Index of Erectile Dysfunction (IIEF) for Thai Population. J Med Assoc Thai 2017; 100: S73.
14. Kongkanand A. An epidemiological study of erectile dysfunction in Thailand (Part 1: Prevalence). Thai Erectile Dysfunction Epidemiologic Study Group (TEDES). J Med Assoc Thai 2000; 83(8): 872–879.
15. Impens AJ, Seibold JR. Vascular alterations and sexual function in systemic sclerosis. Int J Rheumatol 2010; 2010: 139020.
16. Ostojic P, Damjanov N. The impact of depression, microvasculopathy, and fibrosis on development of erectile dysfunction in men with systemic sclerosis. Clin Rheumatol 2007; 26(10): 1671–1674.
17. Nehra A, Hall SJ, Basile G, Bertero EB, Moreland R, Toselli P, et al. Systemic sclerosis and impotence: a clinicopathological correlation. J Urol 1995; 153(4): 1140–1146.
18. Aversa A, Proietti M, Bruzziches R, Salsano F, Spera G. The penile vasculature in systemic sclerosis: A duplex ultrasound study. J Sex Med 2006; 3(3): 554–558.
19. Lally EV, Jimenez SA. Erectile failure in systemic sclerosis. N Engl J Med 1990; 322(19): 1398–1399.
20. Hong P, Pope JE, Ouimet JM, Rullan E, Seibold JR. Erectile dysfunction associated with scleroderma: a case-control study of men with scleroderma and rheumatoid arthritis. J Rheumatol 2004; 31(3): 508–513.