Compliance of Iron Supplementation During Pregnancy

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Romthira Srisai
Jadsada Thinkhamrop
Sukanya Chaiyarach
Sukanya Kreetiyutanont


Background and objectives: This study aimed to determine the compliance rate of iron supplementation and the hemoglobin concentration in second trimester and at term of pregnant women to take into consideration for the optimal practice.

Methods: The study conducted among term pregnant women admission to the hospital for delivery who had non-anemic status at the initial visit for antenatal care, received daily iron supplementation before 20 weeks of gestation. They were interviewed to obtain the personal data, daily taking the supplemented tablet and side-effects. The compliance rate categorized as >80%, >50-80%, 25-50%, and < 25% according to the women’s response that they took daily tablet of 6-7, 3-5, 2, and 0-1 day(s) in one week, respectively. The laboratory results of hemoglobin level were retrieved from their medical records.

Results: Among 350 participants had the compliance rate of >80%. The common side-effects were nausea and constipation.  The side-effect rates were 10.5%, 12.1%, 66.7% in >80%, >50-80%, <25% compliance groups, respectively. While hemoglobin concentrations above 13 gm/dl, which defined as high concentrated hemoglobin, revealed 12% during second trimester, and up to 30% at term in high compliance group.

Conclusions: The pregnant women had compliance rate greater than 80% of taking iron supplementation 6-7 tablet/week.


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Srisai R, Thinkhamrop J, Chaiyarach S, Kreetiyutanont S. Compliance of Iron Supplementation During Pregnancy. Srinagarind Med J [Internet]. 2021 Oct. 4 [cited 2022 Jan. 21];36(5):527-33. Available from:
Original Articles


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