Effectiveness of Oral Deferiprone (GPO-L-ONE®) in Pediatric Thalassemia Patients with Iron Overload, in Krabi Provincial Hospital


  • Sunjutha Sudjan Krabi Hospital, Krabi Province


deferiprone, effectiveness, thalassemia, iron overload


Objective: To study the effectiveness of oral deferiprone (GPO-L-ONE) in pediatric thalassemia patients with iron overload.

Method: A retrospective descriptive study was conducted in pediatric thalassemia patients who had serum ferritin levels above 1,000 µg/L treated with GPO-L-ONE® chelation since 2018 to 2021. Serum ferritin levels were measured every six months and patients were followed up for 30 months. In addition, laboratories and clinical safety monitoring were performed. Paired t–test and repeated measurement ANOVA were used to analyze data.

Result: One hundred and eighty pediatric thalassemia patients were included in this study and they had 7.53 ± 3.73 years of average age with either β-thalassemia/Hb E disease (50%) or Homozygous β-thalassemia (46.11%) or Hb H Constant Spring (3.89%). After treatment for 12, 18, 24 and 30 months, serum ferritin levels were decreased significantly (p=0.004, 0.014, 0.02 and 0.02, Mean difference = -118, -137, -170 and -207 µg/L respectively). Only 56 patients were completely followed up every 6 months for 30 months and the serum ferritin levels at before and after treatment of this group were compared and the levels were nosignificantly decreased from 1282±216 to 1075±619 µg/L. The most common adverse drug reactions observed in patients were increased transaminase followed by neutropenia.

Conclusion: GPO-L-ONE® is an effective oral iron-chelating agent for treatment in pediatric thalassemia with iron overload. However, safety monitoring especially increased transaminase and neutropenia should be closely observed.


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How to Cite

Sudjan S. Effectiveness of Oral Deferiprone (GPO-L-ONE®) in Pediatric Thalassemia Patients with Iron Overload, in Krabi Provincial Hospital. SRIMEDJ [Internet]. 2023 Feb. 24 [cited 2024 Jun. 16];38(1):29-38. Available from: https://li01.tci-thaijo.org/index.php/SRIMEDJ/article/view/256498



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