Secondary Hyperparathyroidism

Authors

  • Sirawit Lertlikitvorakul Department of Surgery, Faculty of Medicine, Thammasat University, Pathum thani province, Thailand
  • Wilairat Thoviriyavej Department of Surgery, Faculty of Medicine, Thammasat University, Pathum thani province, Thailand

Keywords:

Secondary hyperparathyroidism, Subtotal parathyroidectomy, Total parathyroidectomy with autotransplantation, Missing parathyroid gland

Abstract

            Secondary hyperparathyroidism (SHPT) is the most commonly found major complication of chronic kidney disease (CKD) with a prevalence of 12-54%. The stimulation of parathyroid hormone production as a result of hyperphosphatemia and hypocalcemia affects different organ systems in the body. The main options of treatment are medication and surgery by which consists of subtotal parathyroidectomy and  total parathyroidectomy with autotransplantation. In cases with missing parathyroid gland during surgery, intraoperative systematic searching is a preferred way to approach. However, if the parathyroid gland remains missing, the surgery may need to be postponed and two imaging modalities are then required before going on  a second operation. Using the right techniques and understanding of the surgical anatomy of the parathyroid gland helps to decrease the rate of complication, mortality and improves overall quality of life in patients.

References

Brunicardi FC, Andersen DK, Billiar TR, Dunn DL, Hunter JG, Matthews JB, et al. Schwartz's principles of surgery, 10th edition: McGraw-Hill Education; 2014.

van der Plas WY, Noltes ME, van Ginhoven TM, Kruijff S. Secondary and tertiary hyperparathyroidism: A narrative review. Scand J Surg 2020;109(4):271-8. doi: 10.1177/1457496919866015.

Oertli D, Udelsman R. Surgery of the thyroid and parathyroid glands, 2nd edition: Springer Berlin Heidelberg; 2012.

Fischer JE, Ellison EC, Upchurch GR, Galandiuk S, Gould JC, Klimberg V, et al. Fischer’s mastery of surgery, seventh edition: Wolters Kluwer Health Adis; 2018.

Lau WL, Obi Y, Kalantar-Zadeh K. Parathyroidectomy in the management of secondary hyperparathyroidism. Clin J Am Soc Nephrol 2018;13(6):952-61. doi: 10.2215/CJN.10390917.

KDIGO 2017 Clinical practice guideline update for the diagnosis, evaluation, prevention, and treatment of chronic kidney disease-mineral and bone disorder (CKD-MBD). Kidney Int Suppl 2017;7(1):1-59. doi: 10.1016/j.kisu.2017.04.001.

Fukagawa M, Yokoyama K, Koiwa F, Taniguchi M, Shoji T, Kazama JJ, et al. Clinical practice guideline for the management of chronic kidney disease-mineral and bone disorder. Ther Apher Dial 2013;17(3): 247-88. doi: 10.1111/1744-9987.12058.

The EVOLVE trial investigators (2012). Effect of cinacalcet on cardiovascular disease in patients undergoing dialysis. NEJM 2012;367(26):2482-94. doi: 10.1056/NEJMoa1205624.

Alvarado L, Sharma N, Lerma R, Dwivedi A, Ahmad A, Hechanova A, et al. Parathyroidectomy versus cinacalcet for the treatment of secondary hyperparathyroidism in hemodialysis patients. World J Surg 2022;46(4):813-9. doi: 10.1007/s00268-022-06439-7.

Kidney disease: improving global outcomes (KDIGO) transplant work group. KDIGO clinical practice guideline for the care of kidney transplant recipients. Am J Transplant 2009;9(Suppl 3):S1-155. doi: 10.1111/j.1600-6143.2009.02834.x.

Guideline working group, Japanese society for dialysis therapy. Clinical practice guideline for the management of secondary hyperparathyroidism in chronic dialysis patients. Ther Apher Dial 2008;12(6): 514-25. doi: 10.1111/j.1744-9987.2008.00648.x.

Ellison EC, Zollinger RM. Zollinger’s atlas of surgical operations / E. Christopher Ellison. Tenth edition. New York: McGraw Hill Education; 2016.

Anderson K Jr, Ruel E, Adam MA, Thomas S, Youngwirth L, Stang MT, et al. Subtotal vs total parathyroidectomy with autotransplantation for patients with renal hyperparathyroidism have similar outcomes. Am J Surg 2017;214(5):914-9. doi: 10.1016/j.amjsurg.2017.07.018.

Yuan Q, Liao Y, Zhou R, Liu J, Tang J, Wu G. Subtotal parathyroidectomy versus total parathyroidectomy with autotransplantation for secondary hyperparathyroidism: an updated systematic review and meta-analysis. Langenbecks Arch Surg 2019;404(6):669-79. doi: 10.1007/s00423-019-01809-7.

G. Scott Smith MD, Richard A. Prinz MD. Chapter 9. persistent and recurrent hyperparathyroidism. In: Morita SY, Dackiw APB, Zeiger MA, editors. New York, NY: The McGraw-Hill Companies; 2010.

Okada M, Tominaga Y, Yamamoto T, Hiramitsu T, Narumi S, Watarai Y. Location frequency of missed parathyroid glands after parathyroidectomy in patients with persistent or recurrent secondary hyperparathyroidism. World J Surg 2016;40(3):595-9. doi: 10.1007/s00268-015-3312-1.

Tay D, Das JP, Yeh R. Preoperative localization for primary hyperparathyroidism: A clinical review. Biomedicines 2021;9(4):390. doi: 10.3390/biomedicines9040390.

Parikh AM, Grogan RH, Morón FE. Localization of parathyroid disease in reoperative patients with primary hyperparathyroidism. Int J Endocrinol 2020;2020:9649564. doi: 10.1155/2020/9649564.

Gabrielle KS, Jennifer HK. Surgical management of secondary hyperparathyroidism. Kidney Int Rep 2021;6(2):254-64. doi: 10.1016/j.ekir.2020.11.023.

Published

2023-12-23

How to Cite

1.
Lertlikitvorakul S, Thoviriyavej W. Secondary Hyperparathyroidism. SRIMEDJ [Internet]. 2023 Dec. 23 [cited 2024 Nov. 24];38(6):642-51. Available from: https://li01.tci-thaijo.org/index.php/SRIMEDJ/article/view/259189

Issue

Section

Review Articles