Effects of Cannabis Leaf Tea on Sleep Onset Latency, Total Sleep Time, and Wake after Sleep Onset Tracked by a Smartwatch

Authors

  • Naratip Noppawinyoowong Khaosuankwang Hospital, Khon Kaen, Thailand
  • Khemakorn Wongkalasin Khaosuankwang Hospital, Khon Kaen, Thailand
  • Chomtru Poonoangoang Khaosuankwang Hospital, Khon Kaen, Thailand
  • Thapranee Hongpim Khaosuankwang Hospital, Khon Kaen, Thailand
  • Sasithorn Eua-Anant Khon Kaen Provincial Public Health Office, Khon Kaen, Thailand
  • Taweesak Manomayitthikarn Queen Sirikit Heart Center, Khon Kaen University, Khon Kaen, Thailand
  • Pongsak Sapsilathong Khaosuankwang District Public Health Office, Khon Kaen, Thailand

Keywords:

Cannabis leaf tea, sleep onset latency, total sleep time, wake after sleep onset, smartwatch

Abstract

Background and Objective: Cannabis possesses many medicinal properties. Recent studies reported positive results using cannabis derivatives as a sleep aid. This study investigated the effects of cannabis leaf tea on sleep onset latency (SOL), total sleep time (TST), and wake after sleep onset (WASO) in medical personnel using a smartwatch as a sleep tracker.

Methods: This study was designed as a single-arm quasi-experimental trial. The eligible volunteers wore Fitbit Inspire 2 to track their sleep at home for four days, one week apart. On the first day, SOL, TST, and WASO were recorded as baseline data. On the second, third, and fourth days, the volunteers drank low, medium, and high concentrations of cannabis leaf tea approximately 30 minutes before bedtime. The statistical analysis was the Wilcoxon Matched-pairs Signed-rank test.

Result: Sixty-three volunteers were eligible for the trial. The findings revealed that the SOL baseline was different from the SOL of low concentration, the SOL of medium concentration, and the SOL of high concentration with statistical significance (95%CI: 0.00-5.79, p = 0.005, 95%CI: 0.00-8.79, p = 0.002 and 95%CI: 3.21-12.79, p < 0.001, respectively). Only the TST of medium concentration significantly differed from the TST baseline (95%CI: 9.76-42.00, p = 0.037). There was no significant difference between the WASO baseline and the WASO of the three concentrations.

Conclusion: All concentrations of cannabis tea shortened the SOL. However, the medium concentration decreased TST. In addition, all three concentrations could not reduce WASO.

References

Rao TP, Ozeki M, Juneja LR. In search of a safe natural sleep aid. J Am Coll Nutr 2015;34(5):436-47. doi: 10.1080/07315724.2014.926153

Kanyapak S. Efficacy of cannabis oil (Deja’s formula) on out-patients’ sleep quality and quantity of life at Hang Ga Rok Clinic: Phra Adjarn Phan Arjaro Hospital, Sakhn Nakhon province. Regional Health Promotion Center 9 Journal 2022;16(3):1097-108.

Kongnantha S. Sleep quality problem and associated factors in nurse, Bandan hospital. Medical Journal of Srisaket Surin Buriram Hospitals 2022;37(3):609-19.

Kerdcharoen N, Wisitpongaree C, Padermpornromyen C, Jaroennophakunsri C, Sittisak N, Imeuarbpathom N, et al. Work factors related to sleep quality among professional nurses in the in-patient department, Faculty of Medicine, Vajira hospital. Vajira Med J 2020;64(1):41-58. doi doi: 10.14456/vmj.2020.5.

Samorapoom C, Pewchan C, Promrit A. Unlocking cannabis: past to present of laws. Journal of Local Governance and Innovation 2023;7(1):285-302. doi:10.14456/jlgisrru.2023.19

Im-iam S, Saensanor S, Sukcharoen P, Sawasdichai C. Kanja (Cannabis). J Prapokklao Hosp Med Educat Center 2019;36(4):356-62.

Iseger TA, Bossong MG. A systematic review of the antipsychotic properties of cannabidiol in humans. Schizophr Res 2015;162(1-3):153-61. dot doi: 10.1016/j.schres.2015.01.033

Arunpongpaisal S, Anekwit N. The use of cannabis extracts for patients with mental health problems. Journal of the Department of Medical Services 2019;44(1):7-9.

Tiewcharoensopha C, Srisuwan T, Leelapornpisid W. Cannabis and its use in dentistry. Thai Endod J 2022;1(1):43-58.

Walsh JH, Maddison KJ, Rankin T, Murray K, McArdle N, Ree MJ, et al. Treating insomnia symptoms with medicinal cannabis: a randomized, crossover trial of the efficacy of a cannabinoid medicine compared with placebo. Sleep 2021;44(11): zsab149. doi.org/10.1093/sleep/zsab149

Babson KA, Sottile J, Morabito D. Cannabis, cannabinoids, and sleep: a review of the literature. Curr Psychiatry Rep 2017;19(4):1-2. doi doi: 10.1007/s11920-017-0775-9

Mitsungnern T, Tonanon K, Kotruchin P, Vannaprasaht S. Prevalence and clinical characteristics of cannabis exposing patients between pre- and post-medical cannabis legalization era in 2019. Thai Journal of Emergency Medicine 2020;2(2):17-36.

Hazekamp A, Bastola K, Rashidi H, Bender J, Verpoorte R. Cannabis tea revisited: a systematic evaluation of the cannabinoid composition of cannabis tea. J Ethnopharmacol 2007;113(1):85-90. doi: 10.1016/j.jep.2007.05.019

McPartland JM, Pruitt PL. Side effects of pharmaceuticals not elicited by comparable herbal medicines: the case of tetrahydrocannabinol and marijuana. Altern Ther Health Med 1999;5(4):57-63.

Medical Cannabis Institute. Use cannabis wisely and apply it for good health and safety. Nonthaburi: Ministry of Public Health of Thailand, 2022.

Patel AK, Reddy V, Shumway KR, Araujo JF. Physiology, sleep stages. InStatPearls [Internet] 2022 Sep 7. StatPearls Publishing. [cited Jul 6, 2023]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK526132/

KKPHO health data center [Internet]. Khon Kaen: Data center. c2022 - [cited Jul 6, 2022]. Available from: https://kkhdc.moph.go.th/

Liao Y, Robertson MC, Winne A, Wu IH, Le TA, Balachandran DD, et al. Investigating the within-person relationships between activity levels and sleep duration using Fitbit data. Transl Behav Med 2021;11(2):619-24. doi: 10.1093/tbm/ibaa071

Lim SE, Kim HS, Lee SW, Bae KH, Baek YH. Validation of Fitbit Inspire 2TM against polysomnography in adults considering adaptation for use. Nat Sci Sleep 2023;15:59-67. doi: 10.2147/NSS.S391802

Balant M, Gras A, Ruz M, Valles J, Vitales D, Garnatje T. Traditional uses of cannabis: an analysis of the CANNUSE database. J Ethnopharmacol 2021;279:114362. doi: 10.1016/j.jep.2021.114362

Mozaffari K, Willette S, Lucker BF, Kovar SE, Holguin FO, Guzman I. The effects of food on cannabidiol bioaccessibility. Molecules 2021;26(12):3573. doi: 10.3390/molecules26123573

Antoniou T, Bodkin J, Ho JM. Drug interactions with cannabinoids. Can Med Assoc J 2020;192(9):E206. doi: 10.1503/cmaj.191097

Park KS, Choi SH. Smart technologies toward sleep monitoring at home. Biomed Eng Lett 2019;9(1):73-85.

Fonseca P, Weysen T, Goelema MS, Møst EI, Radha M, Lunsingh Scheurleer C, et al. Validation of photoplethysmography-based sleep staging compared with polysomnography in healthy middle-aged adults. Sleep 2017;40(7):1-10. doi: 10.1093/sleep/zsx097

Haghayegh S, Khoshnevis S, Smolensky MH, Diller KR, Castriotta RJ. Accuracy of wristband Fitbit models in assessing sleep: systematic review and meta-analysis. J Med Internet Res 2019;21(11):e16273. doi: 10.2196/16273

Gorelick DA, Goodwin RS, Schwilke E, Schroeder JR, Schwope DM, Kelly DL, et al. Around-the-clock oral THC effects on sleep in male chronic daily cannabis smokers. Am J Addict 2013;22(5):510-4. doi: 10.1111/j.1521-0391.2013.12003.x

Tringale R, Jensen C. Cannabis and insomnia [monograph on the Internet]. O’ Shaughnessy’s Online; 2011 [cited Jun 6, 2023]. Available from: https://www.beyondthc.com/wp-content/uploads/2014/04/Tringale-Jensen-20111.pdf

Nicholson AN, Turner C, Stone BM, Robson PJ. Effect of Δ-9-tetrahydrocannabinol and cannabidiol on nocturnal sleep and early-morning behavior in young adults. J Clin Psychopharmacol 2004;24(3):305-13. doi: 10.1097/01.jcp.0000125688.05091.8f

Colin Cameron MD, Watson D, Robinson J. Use of a synthetic cannabinoid in a correctional population for posttraumatic stress disorder-related insomnia and nightmares, chronic pain, harm reduction, and other indications. J Clin Psychopharmacol 2014;34:559Y564. doi: 10.1097/JCP.0000000000000180

Bell KA, Coleman E, Cooke BG, Keen LD. Recreational cannabis use is associated with poorer sleep outcomes in young adult African Americans. Addict Behav 2022;134:107399. doi: 10/1016/j.addbeh.2022.107399

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Published

2024-02-19

How to Cite

1.
Noppawinyoowong N, Wongkalasin K, Poonoangoang C, Hongpim T, Eua-Anant S, Manomayitthikarn T, Sapsilathong P. Effects of Cannabis Leaf Tea on Sleep Onset Latency, Total Sleep Time, and Wake after Sleep Onset Tracked by a Smartwatch. SRIMEDJ [Internet]. 2024 Feb. 19 [cited 2024 Nov. 5];39(1):24-32. Available from: https://li01.tci-thaijo.org/index.php/SRIMEDJ/article/view/259700

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Original Articles