Effectiveness of Oral Progesterone for Prevent Preterm Birth in Yasothon Hospital
Keywords:
effectiveness, progesterone, preterm birthAbstract
Background and Objective: Preterm birth could lead to severe health issue in infant. Previous studies have not provided definitive evidence regarding the efficacy of oral progesterone in preventing preterm birth. This study aimed to determine incidence and risk factors associated with preterm birth, the effectiveness of oral progesterone and the associated treatment costs.
Methods: We conducted a retrospective cohort study with historical control. The participants were pregnant women at risk of preterm birth who were registered in Yasothon Hospital between January 2022 - March 2023. The total of 155 participants were randomly selected from medical records.
Results: The majority of pregnant women at risk of preterm birth were between the ages of 20-35 year (72.9%).The incidence of preterm birth was 23.3%, with the highest incidence occurring in the 16-19 age group (26.3%). The incidence preterm birth increased with decreasing age. Two factors associated with preterm birth were progesterone using (Adjusted OR: 0.4, 95%CI: 0.2, 0.9) and urinary tract infections (Adjusted OR: 2.5, 95%CI: 1.1, 5.7). The proportion of preterm births in progesterone user group was lower than in the control group (Proportion diff: 14.1, 95%CI: 1.3, 26.9).The average treatment cost per case of the pregnant women at risk of preterm birth was 8,072 Thai Baths.
Conclusions: The group of pregnant women who used oral progesterone tends to have a lower incidence of preterm birth. The treatment costs were deemed reasonable when considering the potential benefit for both the pregnant women and their infants.
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