Factors Affecting the Time to Diagnosis of Tuberculosis in the Head and Neck Region
Keywords:
tuberculosis in the head and neck region, factors, duration, diagnosisAbstract
Background and Objective: Tuberculosis in the head and neck regions present with a variety of symptoms and signs, making diagnosis challenging. Delayed diagnosis could impact patients, leading to decrease quality of life, increase complications, and mortality. This study aimed to determine factors influencing the time to diagnosis of tuberculosis in the head and neck regions within 15 days and beyond 15 days.
Methods: A retrospective cohort study was conducted on patients diagnosed with tuberculosis in the head and neck region at Chaiyaphum hospital from January 1, 2017, to December 31, 2023. Data were collected from medical records. Patients were divided into two groups: those diagnosed within 15 days and those diagnosed beyond 15 days. Factors influencing the diagnosis were analyzed.
Results: Among the 241 patients with head and neck tuberculosis, factors influencing diagnosis statistically significant within 15 days included male gender, body temperature ≥ 37.8°C, symptom duration less than 60 days, HIV infection, multiple site infections, mass size ≥ 3 cm, neutrophil count greater than 80%, and abnormal chest x-ray. Multivariable logistic regression analysis identified symptom duration less than 60 days (AOR 3.51, 95% CI 1.64-7.52), HIV infection (AOR 3.38, 95% CI 1.63-7.03), and multiple site infections (AOR 2.88, 95% CI 1.54-5.39) as factors influencing diagnosis within 15 days.
Conclusion: Factors influencing the time to diagnosis within 15 days include symptom duration less than 60 days, HIV infection, and multiple site infections. These factors can be used to predict the likelihood of head and neck tuberculosis, facilitating further confirmatory testing and leading to prompt and appropriate treatment.
References
World Health Organization. Global tuberculous report 2023 [cited May 15, 2024]. Available from: https://www.who.int/teams/global-tuberculosis-programme/tb-reports/global-tuberculosis-report-2023/tb-disease-burden
Chhabra B, Vyas P, Gupta P, Sharma P, Sharma K. Incidence, diagnosis and treatment of otorhinolaryngological, head and neck tuberculosis: a prospective clinical study. Int Arch Otorhinolaryngol 2023;27(4):e630-5. doi:10.1055/s-0043-1761173.
Gehrke T, Hackenberg S, Tecle N, Hagen R, Scherzad A. Tuberculosis in the head and neck: changing trends and age-related patterns. Laryngoscope 2021;131(12):2701-5. doi:10.1002/lary.29668.
Pang P, Duan W, Liu S, Bai S, Ma Y, Li R, et al. Clinical study of tuberculosis in the head and neck region - 11 years’ experience and a review of the literature. Emerg Microbes Infect 2018;7(1):4. doi:10.1038/s41426-017-0008-7.
Xiang Y, Huang C, He Y, Zhang Q. Cancer or tuberculosis: a comprehensive review of the clinical and imaging features in diagnosis of the confusing mass. Front Oncol 2021;11:644150. doi:10.3389/fonc.2021.644150.
Assefa W, Eshete T, Solomon Y, Kassaye B. Clinicoepidemiologic considerations in the diagnosis of tuberculous lymphadenitis: evidence from a high burden country. Int J Infect Dis 2022;124:152-6. doi:10.1016/j.ijid.2022.09.030.
Chen HK, Liu RS, Wang YX, Quan EX, Liu YH, Guo XG. Xpert MTB/RIF assay for the diagnosis of lymph node tuberculosis in children: a systematic review and meta-analysis. J Clin Med 2022;11(15):4616. doi:10.3390/jcm11154616.
Mathiasen VD, Hansen AK, Eiset AH, Lillebaek T, Wejse C. Delays in the diagnosis and treatment of tuberculous lymphadenitis in low-incidence countries: a systematic review. Respiration 2019;97(6):576-84. doi:10.1159/000499052.
Arega B, Mersha A, Minda A, Getachew Y, Sitotaw A, Gebeyehu T, et al. Epidemiology and the diagnostic challenge of extra-pulmonary tuberculosis in a teaching hospital in Ethiopia. PLoS One 2020; 15(12):e0243945. doi:10.1371/journal.pone.0243945.
Obsa MS, Daga WB, Wosene NG, Gebremedhin TD, Edosa DC, Dedecho AT, et al. Treatment seeking delay and associated factors among tuberculosis patients attending health facility in Ethiopia from 2000 to 2020: a systematic review and meta-analysis. PLoS One 2021;16(7):e0253746. doi:10.1371/journal.pone.0253746.
Mushtaq A, Lodhi AM, Rizwan W, Ruth C, Muzaffar M, Mir A. Clinical spectrum and outcome of extra-pulmonary tuberculosis in children. Professional Med J 2021;28(9):1336-40. doi:10.29309/TPMJ/2021.28.09.6361
Dubois MM, Brooks MB, Malik AA, Siddiqui S, Ahmed JF, Jaswal M, et al. Age-specific clinical presentation and risk factors for extrapulmonary tuberculosis disease in children. Pediatr Infect Dis J 2022;41(8):620-5. doi:10.1097/INF.0000000000003584.
Vivekanand A, Fernandes PS, Tara N. Extrapulmonary head and neck tuberculosis: 3 years experience at a tertiary care centre. Int J Otorhinolaryngol Head Neck Surg 2021;7(9):1486-9. doi:10.18203/issn.2454-5929.ijohns20213285.
Bokare B, Mehta K. Otolaryngological manifestations of tuberculosis: a clinical study. Indian J Otolaryngol Head Neck Surg 2022;74(suppl 3):s5217-24. doi:10.1007/s12070-020-01789-x.
Thorawade VP, Jaiswal SA, Gupta SR. Manifestations of tuberculosis in ear, nose, throat, head and neck region – a retrospective study. BJOHNS 2020;28(2):144-50. doi:10.47210/bjohns.2020.v28i2.332.
Ereso BM, Sagbakken M, Gradmann C, Yimer SA. Total delay and associated factors among tuberculosis patients in Jimma Zone, Southwest Ethiopia. PLoS One 2023;18(2):e0281546. doi:10.1371/journal.pone.0281546.
Sharma S, Rana AK. ENT manifestations of tuberculosis: an important aspect of ENT practice. Pan Afr Med J 2020;36:295. doi:10.11604/pamj.2020.36.295.24823.
Mathiasen VD, Andersen PH, Johansen IS, Lillebaek T, Wejse C. Clinical features of tuberculous lymphadenitis in a low-incidence country. Int J Infect Dis 2020;98:366-71. doi:10.1016/j.ijid.2020.07.011.
Arja A, Bogale B, Gebremedhin M. Health system delay and its associated factors among tuberculosis patients in Gamo Zone public health facilities, Southern Ethiopia: an institution-based cross-sectional study. J Clin Tuberc Other Mycobact Dis 2022;28:100325. doi:10.1016/j.jctube.2022.100325.
Deveci HS, Kule M, Kule ZA, Habesoglu TE. Diagnostic challenges in cervical tuberculous lymphadenitis: a review. North Clin Istanb 2016;3(2):150-5. doi:10.14744/nci.2016.20982.
Sriram R, Bhojwani KM. Manifestations of tuberculosis in otorhinolaryngology practice: a retrospective study conducted in a Coastal city of South India. Indian J Otolaryngol Head Neck Surg 2017;69(2):210-5. doi:10.1007/s12070-017-1079-4.
Kumbi H, Reda DY, Solomon M, Teklehaimanot A, Ormago MD, Ali MM. Magnitude of tuberculosis lymphadnitis, risk factors, and rifampicin resistance at Adama city, Ethiopia: a cross-sectional study. Sci Rep 2023;13(1):15955. doi:10.1038/s41598-023-43206-7.
Bruzgielewicz A, Rzepakowska A, Osuch-Wójcikewicz E, Niemczyk K, Chmielewski R. Tuberculosis of the head and neck - epidemiological and clinical presentation. Arch Med Sci 2014;10(6):1160-6. doi:10.5114/aoms.2013.34637.
Gautam H, Agrawal SK, Verma SK, Singh UB. Cervical tuberculous lymphadenitis: clinical profile and diagnostic modalities. Int J Mycobacteriol 2018;7(3):212-6. doi:10.4103/ijmy.ijmy_99_18.
Tachibana T, Orita Y, Fujisawa M, Nakada M, Ogawara Y, Matsuyama Y, et al. Factors that make it difficult to diagnose cervical tuberculous lymphadenitis. J Infect Chemother 2013;19(6):1015-20. doi:10.1007/s10156-013-0615-8.
Gong X, He Y, Zhou K, Hua Y, Li Y. Efficacy of Xpert in tuberculosis diagnosis based on various specimens: a systematic review and meta-analysis. Front Cell Infect Microbiol 2023;13:1149741. doi:10.3389/fcimb.2023.1149741.
Leutscher P, Madsen G, Erlandsen M, Veirum J, Ladefoged K, Thomsen V, et al. Demographic and clinical characteristics in relation to patient and health system delays in a tuberculosis low-incidence country. Scand J Infect Dis 2012;44(1):29-36. doi:10.3109/00365548.2011.608081.
Seid A, Metaferia Y. Factors associated with treatment delay among newly diagnosed tuberculosis patients in Dessie city and surroundings, Northern Central Ethiopia: a cross-sectional study. BMC Public Health 2018;18(1):931. doi:10.1186/s12889-018-5823-9.
Jørstad MD, Aẞmus J, Marijani M, Sviland L, Mustafa T. Diagnostic delay in extrapulmonary tuberculosis and impact on patient morbidity: a study from Zanzibar. PLoS One 2018;13(9):e0203593. doi:10.1371/journal.pone.0203593.
Osei E, Akweongo P, Binka F. Factors associated with delay in diagnosis among tuberculosis patients in Hohoe Municipality, Ghana. BMC Public Health 2015;15:721. doi:10.1186/s12889-015-1922-z.
Asres A, Jerene D, Deressa W. Delays to anti-tuberculosis treatment initiation among cases on directly observed treatment short course in districts of southwestern Ethiopia: a cross-sectional study. BMC Infect Dis 2019;19(1):481. doi:10.1186/s12879-019-4089-x.
Yimer SA, Bjune GA, Holm-Hansen C. Time to first consultation, diagnosis and treatment of TB among patients attending a referral hospital in Northwest, Ethiopia. BMC Infect Dis 2014;14:19. doi:10.1186/1471-2334-14-19.
Gope A, Baruah KJK, Ojah J, Baruah R. Patient and health system delays among tuberculosis patients attending DOTS centres of Kamrup (metro) district, Assam. Int J Community Med Public Health 2017;4(6):1961-5. doi:10.18203/2394-6040.ijcmph20172157.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Srinagarind Medical Journal
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.