Prevalence of High-Risk HPV Infection in Thai Women in Surin Province and Evaluation of Sensitivity and Specificity of Liquid-Based Cytology (LBC) in Cervical Screening
Keywords:
screening test, prevalence, cervical cancer, HPV infection, liquid-based cytologyAbstract
Background and Objective: To evaluate the prevalence of high-risk human papillomavirus (HPV) strains among Thai women in Surin province and to determine the sensitivity of liquid-based cytology (LBC) in this population.
Methods: This retrospective descriptive study analyzed data obtained from Thai women living in Surin province who participated the cervical cancer screening project as per the service plan of cancer screening, Ministry of Public Health between January 1, 2022, and December 31, 2023. HPV detection was performed using real-time PCR, while LBC was employed for cytological analysis.
Results: Out of 26,371 women who participated in the screening, HPV 16 was the most prevalent strain (0.98%), followed by HPV 52 (0.45%) and HPV 18 (0.35%). The highest prevalence of infection was observed among women aged 41-50 years, with a rate of 2.01%. LBC demonstrated high sensitivity for detecting LSIL or CIN I histology with a sensitivity of 75%. For detecting HSIL, the sensitivity of LBC was 27.8% for CIN II and 70.0% for CIN III histology.
Conclusion: HPV 16 was the most prevalent infection in this study. LBC screening showed high sensitivity for detecting CIN I and CIN III lesions.
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