Secondary Basal Cell Carcinoma after Hematopoiectic Cell Transplantation with Total-Body Irradiation: Case Report
DOI:
https://doi.org/10.64960/srimedj.v40i6.268941Keywords:
basal cell carcinoma, hematopoietic cell transplantation, total body irradiation, secondary malignant neoplasmAbstract
Background and objective: Basal cell carcinoma is the most common skin cancer in the world. Patients who received radiation to the skin a higher risk of developing skin than the general population. That can occur after radiation exposure, even if more than 10-yrs have passed. The long-term follow-up is necessary. The study aimed to study the risk factor and the time to development of secondary malignant neoplasm in patient who has history of a Hematopoietic cell transplantation (HCT) with total body irradiation (TBI) in Khon Kaen Hospital.
Materials and Method: This is a report on a 35-year-old Thai man who underwent surgical treatment in Khon Kaen Hospital for multiple basal cell carcinoma in the area that was previously irradiated.
Results: A 35-year-old Thai man developed multiple basal cell carcinomas on his scalp and pubic area, along with multiple meningiomas in his brain. This is noteworthy because these areas correspond to the sites where he received total body irradiation (TBI), chemotherapy, hematopoietic cell transplantation (HCT) and immunosuppressive drug for acute lymphoblastic leukemia (ALL).
Conclusions: This study reinforces that secondary basal cell carcinoma can occur more than 25-years after radiation exposure, emphasizing the need for long-term surveillance and patient education.
References
Leisenring W, Friedman DL, Flowers MED, Schwartz JL, Deeg HJ. Nonmelanoma skin and mucosal cancers after hematopoietic cell transplantation. J Clin Oncol 2006;24(7):1119-26. doi:10.1200/JCO.2005.02.7052.
Schwartz JL, Kopecky KJ, Mathes RW, Leisenring WM, Friedman DL, Deeg HJ. Basal cell skin cancer after total-body irradiation and hematopoietic cell transplantation. Radiat Res 2009;171(2):155-63. doi:10.1667/RR1469.1.
Deeg HJ, Socie G. Malignancies after hematopoietic stem cell transplantation: many questions, some answers. Blood 1998;91(6):1833-44. doi:10.1182/blood.V91.6.1833.
Rizzo JD, Curtis RE, Socié G, Sobocinski KA, Gilbert E, Landgren O, et al. Solid cancers after allogeneic hematopoietic cell transplantation. Blood 2009;113(5):1175-83. doi:10.1182/blood-2008-05-158782.
van Vloten WA, Hermans J, van Daal WA. Radiation-induced skin cancer and radiodermatitis of the head and neck. Cancer 1987;59(3):411-4. doi:10.1002/1097-0142(19870201)59:3<411::aid-cncr2820590310>3.0.co;2-z.
Li C, Athar M. Ionizing Radiation Exposure and Basal Cell Carcinoma Pathogenesis. Radiat Res 2016;185(3):217-28. doi:10.1667/RR4284.S1.
Ron E, Modan B, Preston D, Alfandary E, Stovall M, Boice Jr JD. Radiation-induced skin carcinomas of the head and neck. Radiat Res 1991;125(3):318-25. doi:10.2307/3578117.
Ron E, Preston DL, Kishikawa M, Kobuke T, Iseki M, Tokuoka S, et al. Skin tumor risk among atomic-bomb survivors in Japan. Cancer Causes Control 1998;9(4):393-401. doi:10.1023/a:1008867617415.
Chen F, Yang SF, Chen CH, Lieu AS, Cheng ST, Huang MY, et al. Secondary basal cell carcinoma of scalp after radiotherapy: A case report. Medicine (Baltimore) 2018;97(36):e12170. doi:10.1097/MD.0000000000012170.
McDaniel B, Steele RB. Basal Cell Carcinoma. [Updated 2024 Mar 13]. In: Stat Pearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan. [cited Jan 15, 2025]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK482439.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Srinagarind Medical Journal
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
