Prevalence and Risk Factors of Dysmenorrhea in Adolescent and Young Adult Women: A Hospital-Based Retrospective Case–Control Study
DOI:
https://doi.org/10.64960/srimedj.v40i6.269214Keywords:
dysmenorrhea, adolescent health, young adult, risk factors, prevalence, endometriosisAbstract
Background and Objective: Dysmenorrhea is a common gynecologic condition that significantly affects women's quality of life. Variations in prevalence across age groups and challenges in distinguishing primary from secondary dysmenorrhea remain concerns, particularly in guiding appropriate management. This study aims to assess the prevalence, risk factors, and underlying causes of dysmenorrhea among individuals in a defined age group seeking care at a hospital.
Methods: A retrospective case-control study (1:3) was conducted at a tertiary hospital by reviewing electronic medical records from January 1 to December 31, 2024. Records of 1,160 patients aged 10–25 with gynecologic conditions were analyzed. Logistic regression was used to identify associated risk factors, with a significance level of 0.05.
Results: Dysmenorrhea prevalence in this age group was 10.5% (290/2,752). Among these cases, 73.4% (213/290) were diagnosed with primary dysmenorrhea, while 26.6% (77/290) had endometriosis. The youngest age of onset was 12 for dysmenorrhea and 16 for endometriosis. Of the affected individuals, 110 (38.7%) were students, with the majority—75 (68.2%)—enrolled in primary and secondary school. Nulliparity (AOR = 2.04; 95% CI: 1.05–3.95; p = 0.034), smoking (AOR = 3.67; 95% CI: 1.28–10.59; p = 0.017), menstrual irregularity (AOR = 1.47; 95% CI: 1.07–2.00; p = 0.016) and heavy menstrual bleeding (AOR = 3.26; 95% CI: 1.77–6.01; p < 0.001) were significant risk factors.
Conclusions: The study highlights the prevalence of dysmenorrhea, as well as key risk factors, among adolescents and young adults. The findings support the need for targeted clinical management and school-based health education and counseling initiatives.
References
Bonnie RJ, Stroud C, Breiner H, Committee on Improving the Health S, Board on Children Y, Medicine I of, et al. Young Adults in the 21st Century. In: Investing in the Health and Well-Being of Young Adults [Internet]. National Academies Press (US); 2015 [cited Jul 20, 2025]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK284782/
Cole TJ. The secular trend in human physical growth: a biological view. Econ Hum Biol 2003;1(2):161–8. doi:10.1016/S1570-677X(02)00033-3.
Adolescent and young adult health [Internet]. [cited Jan 9, 2025]. Available from: https://www.who.int/news-room/fact-sheets/detail/adolescents-health-risks-and-solutions
Dysmenorrhea: Painful Periods [Internet]. [cited Jun 26, 2025]. Available from: https://www.acog.org/womens-health/faqs/dysmenorrhea-painful-periods
Al-Jefout M, Nawaiseh N. Continuous Norethisterone Acetate versus Cyclical Drospirenone 3 mg/Ethinyl Estradiol 20 μg for the management of primary dysmenorrhea in young adult women. J Pediatr Adolesc Gynecol 2016 ;29(2):143–7. doi:10.1016/j.jpag.2015.08.009.
Gantt PA, McDonough PG. Adolescent dysmenorrhea. pediatric clinics of North America [Internet]. 1981 May 1 [cited Jun 26, 2025];28(2):389–95. Available from: https://www.sciencedirect.com/science/article/pii/S0031395516340044
Janssen EB, Rijkers ACM, Hoppenbrouwers K, Meuleman C, D’Hooghe TM. Prevalence of endometriosis diagnosed by laparoscopy in adolescents with dysmenorrhea or chronic pelvic pain: a systematic review. Hum Reprod Update 2013;19(5):570–82. doi:10.1093/humupd/dmt016.
Shim JY, Laufer MR. Adolescent Endometriosis: An Update. Journal of Pediatric and Adolescent Gynecology [Internet]. 2020 Apr [cited Jun 26, 2025];33(2):112–9. Available from: https://linkinghub.elsevier.com/retrieve/pii/S1083318819303651
Woosley JA, Lichstein KL. Dysmenorrhea, the menstrual cycle, and sleep. Behav Med 2014;40(1):14–21. doi:10.1080/08964289.2013.829020.
Zannoni L, Giorgi M, Spagnolo E, Montanari G, Villa G, Seracchioli R. Dysmenorrhea, absenteeism from school, and symptoms suspicious for endometriosis in adolescents. J Pediatr Adolesc Gynecol 2014;27(5):258–65. doi:10.1016/j.jpag.2013.11.008.
Farland LV, Harris HR. Long-term Health Consequences of Endometriosis – Pathways and Mediation by Treatment. Curr Obstet Gynecol Rep 2020;9(3):79–88. doi:10.1007/s13669-020-00287-9.
Maulenkul T, Kuandyk A, Makhadiyeva D, Dautova A, Terzic M, Oshibayeva A, et al. Understanding the impact of endometriosis on women’s life: an integrative review of systematic reviews. BMC Women’s Health 2024;24(1):524. doi:10.1186/s12905-024-03369-5.
Namazi M, Behboodi Moghadam Z, Zareiyan A, Jafarabadi M. Impact of endometriosis on reproductive health: an integrative review. J Obstet Gynaecol 2021;41(8):1183–91. doi:10.1080/01443615.2020.1862772.
Mann J, Shuster J, Moawad N. Attributes and barriers to care of pelvic pain in university women. J Minim Invasive Gynecol 2013;20(6):811–8. doi:10.1016/j.jmig.2013.05.003.
Greene R, Stratton P, Cleary SD, Ballweg ML, Sinaii N. Diagnostic experience among 4,334 women reporting surgically diagnosed endometriosis. Fertility and Sterility [Internet]. 2009 Jan 1 [cited Jun 26, 2025];91(1):32–9. Available from: https://www.fertstert.org/article/S0015-0282(07)04085-X/fulltext
Boerner KE, Chambers CT, McGrath PJ, LoLordo V, Uher R. The effect of parental modeling on child pain responses: the role of parent and child sex. J Pain 2017;18(6):702–15. doi:10.1016/j.jpain.2017.01.007.
Tangchai K, Titapant V, Boriboonhirunsarn D. Dysmenorrhea in Thai adolescents: prevalence, impact and knowledge of treatment. J Med Assoc Thai 2004;87 (Suppl 3):S69-73.
Chaudhuri A, Singh A, Dhaliwal L. A randomised controlled trial of exercise and hot water bottle in the management of dysmenorrhoea in school girls of Chandigarh, India. Indian J Physiol Pharmacol 2013;57(2):114–22.
Unger CA, Laufer MR. Progression of endometriosis in non-medically managed adolescents: a case series. J Pediatr Adolesc Gynecol 2011;24(2):e21-23. doi:10.1016/j.jpag.2010.08.002.
Karout S, Soubra L, Rahme D, Karout L, Khojah HMJ, Itani R. Prevalence, risk factors, and management practices of primary dysmenorrhea among young females. BMC Women’s Health [Internet]. 2021;21(1):392. doi:10.1186/s12905-021-01532-w.
Society for Adolescent Health and Medicine.Young adult health and well-being: a position statement of the society for adolescent health and medicine. J Adolesc Health 2017;60(6):758-9. doi:10.1016/j.jadohealth.2017.03.021.
Dysmenorrhea and Endometriosis in the Adolescent | ACOG [Internet]. [cited Jun 24, 2025]. Available from: https://kku.world/iwmkcd23.
Nicolaus K, Reckenbeil L, Bräuer D, Sczesny R, Diebolder H, Runnebaum IB. Cycle-related diarrhea and dysmenorrhea are independent predictors of peritoneal endometriosis, cycle-related dyschezia is an independent predictor of rectal involvement. Geburtshilfe Frauenheilkd 2020;80(3):307–15. doi:10.1055/a-1033-9588.
Exacoustos C, Manganaro L, Zupi E. Imaging for the evaluation of endometriosis and adenomyosis. Best Pract Res Clin Obstet Gynaecol 2014;28(5):655–81. doi:10.1016/j.bpobgyn.2014.04.010.
Querleu D, Parmentier D, Chevallier L. [Ovarian cysts: strategy and prognosis]. Contracept Fertil Sex 1993;21(2):167–72.
Weissman AM, Hartz AJ, Hansen MD, Johnson SR. The natural history of primary dysmenorrhoea: a longitudinal study. BJOG 2004;111(4):345–52. doi:10.1111/j.1471-0528.2004.00090.x.
CDC. Adult BMI Categories [Internet]. BMI. 2024 [cited Jul 20, 2025]. Available from: https://www.cdc.gov/bmi/adult-calculator/bmi-categories.html
Lee HS. Why should we be concerned about early menarche? Clin Exp Pediatr 2020;64(1):26–7. doi:10.3345/cep.2020.00521.
Attia GM, Alharbi OA, Aljohani RM. The impact of irregular menstruation on health: a review of the literature. Cureus 2023;15(11):e49146. doi:10.7759/cureus.49146.
McKenna KA, Fogleman CD. Dysmenorrhea. afp [Internet]. 2021 Aug [cited Jul 9, 2025];104(2):164–70. Available from: https://www.aafp.org/pubs/afp/issues/2021/0800/p164.html
Qin LL, Hu Z, Kaminga AC, Luo BA, Xu HL, Feng XL, et al. Association between cigarette smoking and the risk of dysmenorrhea: A meta-analysis of observational studies. PLoS One 2020;15(4):e0231201. doi:10.1371/journal.pone.0231201.
White IR, Royston P, Wood AM. Multiple imputation using chained equations: Issues and guidance for practice. Stat Med 2011;30(4):377-99. doi:10.1002/sim.4067.
De Sanctis V, Soliman A, Bernasconi S, Bianchin L, Bona G, Bozzola M, et al. Primary dysmenorrhea in adolescents: prevalence, impact and recent knowledge. Pediatr Endocrinol Rev 2015;13(2):512–20.
Latthe P, Mignini L, Gray R, Hills R, Khan K. Factors predisposing women to chronic pelvic pain: systematic review. BMJ 2006;332(7544):749–55. doi:10.1136/bmj.38748.697465.55.
Itani R, Soubra L, Karout S, Rahme D, Karout L, Khojah HMJ. Primary dysmenorrhea: pathophysiology, diagnosis, and treatment updates. Korean J Fam Med 2022 ;43(2):101–8. doi:10.4082/kjfm.21.0103.
Iacovides S, Avidon I, Baker FC. What we know about primary dysmenorrhea today: a critical review. Hum Reprod Update 2015;21(6):762–78. doi:10.1093/humupd/dmv039.
Dawood MY. Primary dysmenorrhea: advances in pathogenesis and management. Obstet Gynecol 2006;108(2):428–41. doi:10.1097/01.AOG.0000230214.26638.0c.
Baron JA. Smoking and estrogen-related disease. Am J Epidemiol 1984;119(1):9–22. doi:10.1093/oxfordjournals.aje.a113730.
Hornsby PP, Wilcox AJ, Weinberg CR. Cigarette smoking and disturbance of menstrual function. Epidemiology 1998; 9(2):193–8.
Ju H, Jones M, Mishra GD. Smoking and trajectories of dysmenorrhoea among young Australian women. Tob Control 2016;25(2):195–202. doi:10.1136/tobaccocontrol-2014-051920.
Age of Menarche by Country 2025 [Internet]. worldpopulationreview.com. [cited Jul 20, 2025]. Available from: https://worldpopulationreview.com/country-rankings/age-of-menarche-by-country
De Corte P, Klinghardt M, von Stockum S, Heinemann K. Time to diagnose endometriosis: current status, challenges and regional characteristics—a systematic literature review. BJOG 2025;132(2):118–30. doi:10.1111/1471-0528.17973.
Burney RO, Giudice LC. Pathogenesis and pathophysiology of endometriosis. Fertil Steril [Internet]. 2012;98(3):10.1016/j.fertnstert.2012.06.029. doi:10.1016/j.fertnstert.2012.06.029.
Sutton CJ, Ewen SP, Whitelaw N, Haines P. Prospective, randomized, double-blind, controlled trial of laser laparoscopy in the treatment of pelvic pain associated with minimal, mild, and moderate endometriosis. Fertil Steril 1994; 62(4):696–700. doi:10.1016/s0015-0282(16)56990-8.
Ubochi NE, Chinweuba UA, Iheanacho NP, Osuchukwu EC, Nwodo CO, Nnamani AJ, et al. Menstruation behaviour influencer model: a grounded theory of menstrual experiences of shame, embarrassment, stigma and absenteeism among pubescent girls in semi-urban and rural secondary schools in Enugu State, Nigeria. Pan Afr Med J 2023 ;45:47. doi:10.11604/pamj.2023.45.47.39675.
Wong LP, Khoo EM. Dysmenorrhea in a multiethnic population of adolescent Asian girls. International Journal of Gynecology & Obstetrics [Internet]. 2010;108(2):139–42. doi:10.1016/j.ijgo.2009.09.018.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Srinagarind Medical Journal

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
