EFFECTIVENESS OF TEXT MESSAGING VIA APPLICATION LINE ON ADHERENCE TO ANTIRETROVIRAL DRUG AMONG HIV AND AIDS PATIENTS IN KHAOYOI HOSPITAL PHETCHABURI
DOI:
https://doi.org/10.69598/tbps.17.2.83-99Keywords:
text messaging, LINE application, adherence, antiretroviral drug, HIV, AIDSAbstract
This research aimed to study the effectiveness of text messaging via application LINE on adherence to antiretroviral drug, viral suppression, and CD4 count among HIV and AIDS patients. Thirty-six HIV and AIDS patients who received services and antiretroviral drug at antiretroviral drug clinic Khaoyoi hospital were randomized to intervention (n=18) or control group (n=18). Patients in the intervention group received weekly text messages via the application LINE for 24 weeks and patients can interact and seek advice from a pharmacist. Patients in the control group received standard care from antiretroviral drug clinic. The results were adherence to antiretroviral drug, CD4 levels, viral load suppression, and patient satisfaction. Data were analysed by descriptive and univariate and multivariate with generalized estimating equation. The results of the study found that after 24 weeks of text messaging via application LINE, the mean adherence to antiretroviral drug was higher with statistical significance at week 24 (p<0.001). The mean adherence to antiretroviral drug in the intervention group and the control group was 98.07 ± 2.49 and 85.84 ± 15.41, respectively. CD4 levels was higher with statistical significance (p=0.024). The mean CD4 level in intervention group and the control group was 420.00 ± 153.55 cell/mm3 and 292.78 ± 168.93 cell/mm3, respectively. There were no significant difference in viral suppression between the intervention and control group. An analysis with generalized estimation equations found that text messaging via application LINE could significantly improve adherence to antiretroviral drug and CD4 levels (p=0.001 and 0.037, respectively). Satisfaction with the text messages via the application LINE found that most of the patients rated their satisfaction in the range of 4.20 - 5.00 which is the highest level of satisfaction. Thus, text messaging via application LINE are effective in improving adherence to antiretroviral drug and CD4 count among HIV and AIDS patients. These findings may be of potential benefit for development of HIV and AIDS services.
References
Department of Health and Human Services. Guidelines for the Use of Antiretroviral Agents in Adults and Adolescents Living with HIV [internet]. Geneva: UNAIDS; 2018 [cited 2018 Aug 1]. Available from: https://aidsinfo.nih.gov/contentfiles/lvguidelines/AdultandAdolescentGL.pdf
UNAIDS Joint United Nations Programme on HIV/AIDS. UNAIDS DATA 2021 [internet]. Geneva: UNAIDS; 2021 [cited 2022 Feb 6]. Available from: https://www.unaids.org/sites/default/files/media_asset/JC3032_AIDS_Data_book_2021_En.pdf
HIV AIDS Asia Pacific Research Statistical Data Information Resources AIDS Data Hub. Data Dashboard [internet]. Geneva: AIDS Data Hub; 2020 [cited 2022 Feb 6]. Available from: http://aphub.unaids.org/
Max Roser and Hannah Ritchie. HIV/AIDS [internet]. Wales: Global Change Data Lab; 2021 [cited 2022 Feb 6]. Available from: https://ourworldindata.org/hiv-aids
Institute for Health Metrics and Evaluation. Thailand Top 10 causes of death in 2019 [internet]. Seattle: IHME; 2022 [cited 2022 Feb 6]. Available from: http://www.healthdata.org/thailand
Putlerpong C, Monthakarnkul P, Sonthisombut P, Sunthimaleeworakul W, Puttharachayakul S, Hirundit U. Handbook for pharmacists treatment for people living with HIV and AIDS Bangkok: People's Company Limited; 2012. (in Thai)
Paterson DL, Swindells S, Mohr J, Brester M, Vergis EN, Squier C, et al. Adherence to protease inhibitor therapy and outcomes in patients with HIV infection. Ann Intern Med. 2000;133(1):21-30.
Mannheimer S, Friedland G, Matts J, Child C, Chesney M. The consistency of adherence to antiretroviral therapy predicts biologic outcomes for human immunodeficiency virus-infected persons in clinical trials. Clinical infectious diseases: an official publication of the Infectious Diseases Society of America. 2002;34(8):1115-21.
Bezabhe WM, Chalmers L, Bereznicki LR, Peterson GM. Adherence to antiretroviral therapy and virologic failure: a meta-analysis. Medicine. 2016;95(15):e3361.
Division of AIDS and STDs Department of Disease Control Ministry of Public Health. Thailand National Guidelines on HIV/AIDS Diagnosis, Treatment and Prevention 2020/2021. Bangkok: Graphic and Design Publishing Company Limited Partnership; 2020. (in Thai)
Punsreniramon K. Adherence of antiretroviral therapy in HIV-infected/AIDS patients: Application of transtheoretical model [Thesis]. Master of Science in Pharmacy Program in Clinical Pharmacy. Bangkok: Chulalongkorn University; 2006. (in Thai)
Promnoi K. Adherence of antiretroviral therapy in HIV-infection/AIDS patients: case study in Kongkrilas Hospital, Sukhothai province [Indepentdent study]. Master of Public Health. Pitsanulok: Naresuan University; 2010. (in Thai)
Boonchai P. An Application of Health Belief Model and Social Support on Health Behavior Development among HIV/AIDS patients who have treated with Antiretroviral drug in Buntharik Hospital, Ubonratchathani [Thesis]. Master of Public Health. Ubonratchathani: Ubonratchathani University; 2010. (in Thai)
Thamkul D, Inthong Y, Krutkat S, Thepworachai U. Factors affecting the adherence to antiretroviral medication among HIV/AIDS patients. J Health Sci Res. 2010;2:1-11. (in Thai)
Belzer ME, Kolmodin MacDonell K, Clark LF, Huang J, Olson J, Kahana SY, et al. Acceptability and feasibility of a cell phone support intervention for youth living with HIV with nonadherence to antiretroviral therapy. AIDS patient care STDS. 2015;29(6):338-45.
Morrison SD, Rashidi V, Sarnquist C, Banushi VH, Hole MK, Barbhaiya NJ, et al. Antiretroviral therapy adherence and predictors to adherence in Albania: a cross-sectional study. J Infection Dev Ctries. 2014;8(7):853-62.
Coomes CM, Lewis MA, Uhrig JD, Furberg RD, Harris JL, Bann CM. Beyond reminders: a conceptual framework for using short message service to promote prevention and improve healthcare quality and clinical outcomes for people living with HIV. AIDS care. 2012;24(3):348-57.
Detsis M, Tsioutis C, Karageorgos SA, Sideroglou T, Hatzakis A, Mylonakis E. Factors sssociated with HIV testing and HIV treatment adherence: a systematic review. Curr Pharmaceut Des. 2017;23(18):2568-78.
Dowshen N, Kuhns LM, Johnson A, Holoyda BJ, Garofalo R. Improving adherence to antiretroviral therapy for youth living with HIV/AIDS: a pilot study using personalized, interactive, daily text message reminders. J Med Internet Res. 2012;14(2):e51.
Lewis MA, Uhrig JD, Bann CM, Harris JL, Furberg RD, Coomes C, et al. Tailored text messaging intervention for HIV adherence: a proof-of-concept study. Health Psychol. 2013;32(3):248-53.
Belzer ME, Naar-King S, Olson J, Sarr M, Thornton S, Kahana SY, et al. The use of cell phone support for non-adherent HIV-infected youth and young adults: an initial randomized and controlled intervention trial. AIDS Behav. 2014;18(4):686-96.
Kanters S, Park JJ, Chan K, Socias ME, Ford N, Forrest JI, et al. Interventions to improve adherence to antiretroviral therapy: a systematic review and network meta-analysis. The Lancet HIV. 2017;4(1):e31-e40.
Finitsis DJ, Pellowski JA, Johnson BT. Text message intervention designs to promote adherence to antiretroviral therapy (ART): a meta-analysis of randomized controlled trials. PloS one. 2014;9(2):e88166.
Pop-Eleches C, Thirumurthy H, Habyarimana JP, Zivin JG, Goldstein MP, de Walque D, et al. Mobile phone technologies improve adherence to antiretroviral treatment in a resource-limited setting: a randomized controlled trial of text message reminders. AIDS. 2011;25(6):825-34.
Lester RT, Ritvo P, Mills EJ, Kariri A, Karanja S, Chung MH, et al. Effects of a mobile phone short message service on antiretroviral treatment adherence in Kenya (WelTel Kenya1): a randomised trial. Lancet. 2010;376(9755):1838-45.
Cooper V, Clatworthy J, Whetham J, Consortium E. mHealth interventions to support self-management in HIV: a systematic review. Open AIDS J. 2017;11:119-32.
Linecorp [Internet]. Bangkok: LINE Corporation Thailand; 2021 [cited 2022 Feb 6]. Available from: https://linecorp.com/th/pr/news/th/2022/4073 (in Thai).
Dean AG, Sullivan KM, Soe MM. OpenEpi: Open Source Epidemiologic Statistics for Public Health [cited 2020 8 Jan]. Available from: http://www.openepi.com/SampleSize/SSMean.htm
Abdulrahman SA, Rampal L, Ibrahim F, Radhakrishnan AP, Kadir Shahar H, Othman N. Mobile phone reminders and peer counseling improve adherence and treatment outcomes of patients on ART in Malaysia: A randomized clinical trial. PloS One. 2017;12(5):e0177698.
Lester RT, Mills EJ, Kariri A, Ritvo P, Chung M, Jack W, et al. The HAART cell phone adherence trial (WelTel Kenya1): a randomized controlled trial protocol. Trials. 2009;10:87.
Tunpongjaroen S. Educational intervention by pharmacist on adherence to antiretroviral therapy at Vachiraphuket Hospital[Thesis]. Master of Science in Pharmacy Program in Clinical Pharmacy. Bangkok: Chulalongkorn University; 2003. (in Thai)
Ventuneac A, Kaplan-Lewis E, Buck J, Roy R, Aberg CE, Duah BA, et al. A mobile health intervention in HIV primary care: supporting patients at risk for ART non-adherence. HIV Res Clin Pract. 2020;21(5):140-50.
Han S, Pei Y, Zhao R, Hu Y, Zhang L, Qi X, et al. Effects of a symptom management intervention based on group sessions combined with a mobile health application for persons living with HIV in China: A randomized controlled trial. Int J Nurs Sci. 2021;8(4):370-9.
Promrat S, Kapol P, Kapol N. Effects of a program to promote medication adherence using telepharmacy in patients with hypertension. Thai Bull Pharm Sci. 2022;17(1):31-41. (in Thai)
Sitkulanan P, Kumtip P. Impact of a Self-management programme monitored through the application LINE on eating behaviour, arm-swing exercise behaviour, and blood glucose levels in women with gestational diabetes mellitus. J Nurs Res Thail. 2020;35(2):52-69. (in Thai)
Opanasopit T, Natprayut N, Juanjang N, Ounpong K. Effects of self-regulation program with peer support group through line application for weight control of healthcare providers. Thai Bull Pharm Sci. 2021;16(1):109-21.
Wungrath J, Autorn N. Effectiveness of Line application and telephone-based counseling to improve medication adherence: A randomized control trial study among uncontrolled type 2 diabetes patients. Health Promot Perspect. 2021;11(4):438-43.
Veerakul K. Factors Affecting the Cooperation of Treatment Behavior among HIV Infected/ AIDS Patients Attending Antiretroviral Therapy Program at Thung Tako Hospital, Chumphon Province [Thesis]. Master of Public Health. Nonthaburi: Sukhothai Thammathirat Open University; 2011. (in Thai)
Oh KS, Han E. A comparison of medication adherence and viral suppression in antiretroviral treatment-naïve patients with HIV/AIDS depending on the drug formulary. PloS One. 2021;16(1):e0245185.
Lucas GM. Antiretroviral adherence, drug resistance, viral fitness and HIV disease progression: a tangled web is woven. J Antimicrob Chemother. 2005;55(4):413-6.
Achhra AC, Petoumenos K, Law MG. Relationship between CD4 cell count and serious long-term complications among HIV-positive individuals. Curr Opin HIV AIDS. 2014;9(1):63-71.
Pacheco YM, Jarrin I, Rosado I, Campins AA, Berenguer J, Iribarren JA, et al. Increased risk of non-AIDS-related events in HIV subjects with persistent low CD4 counts despite cART in the CoRIS cohort. Antiviral Res. 2015;117:69-74.
Downloads
Published
How to Cite
Issue
Section
License
All articles published and information contained in this journal such as text, graphics, logos and images is copyrighted by and proprietary to the Thai Bulletin of Pharmaceutical Sciences, and may not be reproduced in whole or in part by persons, organizations, or corporations other than the Thai Bulletin of Pharmaceutical Sciences and the authors without prior written permission.
