CARBON DOTS FOR ANTIBACTERIAL PHOTOTHERAPY
DOI:
https://doi.org/10.69598/tbps.20.1.1-15Keywords:
antibacterial activity, carbon dots, nanoparticles, phototherapyAbstract
Infectious diseases are a significant concern for public health systems in Thailand and worldwide, especially the issue of antibiotic resistance in inhibiting bacterial growth. At present, nanoparticles are being applied as antibacterial agents because they can enhance efficacy through photo-stimulation, are non-damaging to normal cells or tissues, have low toxicity, and do not contribute to drug resistance. Additionally, they help reduce side effects compared to traditional antibiotic treatment methods. Carbon dots are one of the nanoparticles that can be applied as antibacterial agents. They have advantages over other types of nanoparticles, including their unique optical properties, fluorescence characteristics, absorption of light in both ultraviolet and visible ranges, and crucial characteristics for phototherapy. Moreover, they show biocompatibility, low toxicity, water dispersion, ease of synthesis, rapid stability, and capability of functionalization on the surface. This article compiles general information, synthesis methods, mechanisms of bacterial inhibition, and principles of antibacterial activity enhancement by antimicrobial phototherapy of carbon dots.
References
Wang L, Hu C, Shao L. The antimicrobial activity of nanoparticles: Present situation and prospects for the future. Int J Nanomedicine. 2017;12:1227-49.
Liu Y, Roy S, Sarkar S, Xu J, Zhao Y, Zhang J. A review of carbon dots and their composite materials for electrochemical energy technologies. Carbon Energy. 2021;3(5):795-826.
Xu X, Ray R, Gu Y, Ploehn H, Gearheart L, Raker K, et al. Electrophoretic analysis and purification of fluorescent single-walled carbon nanotube fragments. J Am Chem Soc. 2004;126(40):12736-7.
Liu J, Li R, Yang B. Carbon dots: A new type of carbon-based nanomaterial with wide applications. ACS Cent Sci. 2020;6(12):2179-95.
Hussen NH, Hasan AH, FaqiKhedr YM, Bogoyavlenskiy A, Bhat AR, Jamalis J. Carbon dot based carbon nanoparticles as potent antimicrobial, antiviral, and anticancer agents. ACS Omega. 2024;9(9):9849-64.
Dong X, Liang W, Meziani MJ, Sun YP, Yang L. Carbon dots as potent antimicrobial agents. Theranostics. 2020;10(2):671-86.
Zhou Q, Zhang L, Wu H. Nanomaterials for cancer therapies. Nanotechnol Rev. 2017;6(5):473-96.
Wang C, Hu T, Wen Z, Zhou J, Wang X, Wu Q, et al. Concentration-dependent color tunability of nitrogen-doped carbon dots and their application for iron(III) detection and multicolor bioimaging. J Colloid Interface Sci. 2018;521:33-41.
Chu KW, Lee SL, Chang CJ, Liu L. Recent progress of carbon dot precursors and photocatalysis applications. Polymers. 2019;11(4):689.
Chang Q, Zhou X, Xiang G, Jiang S, Li L, Wang Y, et al. Full color fluorescent carbon quantum dots synthesized from triammonium citrate for cell imaging and white LEDs. Dyes Pigm. 2021;193(18):109478.
Ding H, Zhou XX, Zhang ZH, Zhao YP, Wei JS, Xiong HM. Large scale synthesis of full-color emissive carbon dots from a single carbon source by a solvent-free method. Nano Res. 2021;15(4):3548-55.
Dechsri K, Suwanchawalit C, Chitropas P, Opanasopit P, Pengnam S. Carbon dots and their pharmaceutical applications. Thai Bull Pharm Sci. 2022;17(2):37-52. (in Thai)
Khayal A, Dawane V, Amin MA, Tirth V, Yadav VK, Algahtani A, et al. Advances in the methods for the synthesis of carbon dots and their emerging applications. Polymers. 2021;13(18):3190.
Jorns M, Pappas D. A review of fluorescent carbon dots, their synthesis, physical and chemical characteristics, and applications. Nanomaterials. 2021;11(6):1448.
Zhou J, Sheng Z, Han H, Zou M, Li C. Facile synthesis of fluorescent carbon dots using watermelon peel as a carbon source. Mater Lett. 2012;66(1):222-4.
Tan XW, Romainor ANB, Chin SF, Ng SM. Carbon dots production via pyrolysis of sago waste as potential probe for metal ions sensing. J. Anal. Appl. Pyrol. 2014;105:157-65.
Akhgari F, Samadi N, Farhadi K, Akhgari M. A green one-pot synthesis of nitrogen and sulfur co-doped carbon quantum dots for sensitive and selective detection of cephalexin. Can J Chem. 2017;95(6):641-8.
Pierrat P, Wang R, Kereselidze D, Lux M, Didier P, Kichler A, et al. Efficient in vitro and in vivo pulmonary delivery of nucleic acid by carbon dot-based nanocarriers. Biomater. 2015;51:290-302.
Chen W, Hu C, Yang Y, Cui J, Liu Y. Rapid synthesis of carbon dots by hydrothermal treatment of lignin. Mater. 2016;9(3):184.
Sun L, Zhang H, Wang Y, Xiong Z, Zhao X, Xia Y. Chitosan-derived N-doped carbon dots for fluorescent determination of nitrite and bacteria imaging. Spectrochim Acta A Mol Biomol Spectrosc. 2021;251:119468.
Duan Q, Ma Y, Che M, Zhang B, Zhang Y, Li Y, et al. Fluorescent carbon dots as carriers for intracellular doxorubicin delivery and track. J Drug Deliv Sci Technol. 2019;49:527-33.
Chahal S, Yousefi N, Tufenkji N. Green synthesis of high quantum yield carbon dots from phenylalanine and citric acid: Role of stoichiometry and nitrogen doping. ACS Sustain Chem Eng. 2020;8(14):5566-75.
Qu X, Gao C, Fu L, Chu Y, Wang JH, Qiu H, et al. Positively charged carbon dots with antibacterial and antioxidant dual activities for promoting infected wound healing. ACS Appl Mater Interfaces. 2023;15(15):18608-19.
Ye Z, Li G, Lei J, Liu M, Jin Y, Li B. One-step and one-precursor hydrothermal synthesis of carbon dots with superior antibacterial activity. ACS Appl Bio Mater. 2020;3(10):7095-102.
Lee C, Kwon W, Beack S, Lee D, Park Y, Kim H, et al. Biodegradable nitrogen-doped carbon nanodots for non-invasive photoacoustic imaging and photothermal therapy. Theranostics. 2016;6(12):2196-208.
Wibowo A, Jahir Khan M, Sansanaphongpricha K, Khemthong P, Laosiripojana N, Yu YS, et al. Carbon dots in photodynamic therapy: The role of dopant and solvent on optical and photo-responsive properties. Chemistry. 2024;30(54):e202400885.
Fatehbasharzad P, Fatehbasharzad P, Sillanpää M, Shamsi Z. Investigation of bioimpacts of metallic and metallic oxide nanostructured materials: Size, shape, chemical composition, and surface functionality: A review. Part Part Syst Char. 2021;38(10):2100112.
Li P, Sun L, Xue S, Qu D, An L, Wang X, et al. Recent advances of carbon dots as new antimicrobial agents. SmartMat. 2022;3(2):226-48.
Zhang Q, Wang R, Feng B, Zhong X, Ostrikov KK. Photoluminescence mechanism of carbon dots: Triggering high-color-purity red fluorescence emission through edge amino protonation. Nat Commun. 2021;12(1):6856.
Ali Alghamdi B, Al-Johani I, Al-Shamrani JM, Musamed Alshamrani H, Al-Otaibi BG, Almazmomi K, et al. Antimicrobial resistance in methicillin-resistant staphylococcus aureus. Saudi J Biol Sci. 2023;30(4):103604.
Li B, Zhao S, Huang L, Wang Q, Xiao J, Lan M. Recent advances and prospects of carbon dots in phototherapy. J Chem Eng. 2021;408:127245.
Amaral SI, Costa-Almeida R, Gonçalves IC, Magalhães FD, Pinto AM. Carbon nanomaterials for phototherapy of cancer and microbial infections. Carbon. 2022;190:194-244.
Dediu V, Ghitman J, Gradisteanu Pircalabioru G, Chan KH, Iliescu FS, Iliescu C. Trends in photothermal nanostructures for antimicrobial applications. Int J Mol Sci. 2023;24(11):9375.
Jia Q, Zheng X, Ge J, Liu W, Ren H, Chen S, et al. Synthesis of carbon dots from Hypocrella bambusae for bimodel fluorescence/photoacoustic imaging-guided synergistic photodynamic/photothermal therapy of cancer. J Colloid Interface Sci. 2018;526:302-11.
Bao X, Yuan Y, Chen J, Zhang B, Li D, Zhou D, et al. In vivo theranostics with near-infrared-emitting carbon dots-highly efficient photothermal therapy based on passive targeting after intravenous administration. Light Sci Appl. 2018;7:91.
Liang J, Li W, Chen J, Huang X, Liu Y, Zhang X, et al. Antibacterial activity and synergetic mechanism of carbon dots against gram-positive and -negative bacteria. ACS Appl Bio Mater. 2021;4(9):6937-45.
Yan H, Zhang B, Zhang Y, Su R, Li P, Su W. Fluorescent carbon dot–curcumin nanocomposites for remarkable antibacterial activity with synergistic photodynamic and photothermal abilities. ACS Appl Bio Mater. 2021;4(9):6703-18.
Dechsri K, Suwanchawalit C, Patrojanasophon P, Opanasopit P, Pengnam S, Charoenying T, et al. Photodynamic antibacterial therapy of gallic acid-derived carbon-based nanoparticles (GACNPs): Synthesis, characterization, and hydrogel formulation. Pharmaceutics. 2024;16(2):254.
Aranaz I, Alcántara AR, Civera MC, Arias C, Elorza B, Heras Caballero A, et al. Chitosan: An overview of its properties and applications. Polymers. 2021;13(19):3256.
Downloads
Published
How to Cite
Issue
Section
License
All articles published and information contained in this journal such as text, graphics, logos and images is copyrighted by and proprietary to the Thai Bulletin of Pharmaceutical Sciences, and may not be reproduced in whole or in part by persons, organizations, or corporations other than the Thai Bulletin of Pharmaceutical Sciences and the authors without prior written permission.
