ELECTROSPINNING OF POLYHYDROXYALKANOATE (PHA) FOR BIOMEDICAL APPLICATION: A REVIEW
Keywords:
Biocompatibility, Biomaterials, Electrospinning, Polyhydroxyalkanoate, BiomedicalAbstract
Electrospinning is simple and is a cheap method that can be used to produce small-diameter fibrous structures with potential biomedical applications. The process uses a high-voltage electrical field to form solid fibres from a polymeric fluid jet delivered through a millimetre-scale nozzle. Normally, natural polymers for biomedical applications are collagen, alginate, hyaluronan and chitosan, and the synthetic polymers include poly (lactic acid) (PLA) and poly (glycolic acid) (PGA). However, the polymeric scaffolds show rapid strength degradation in vivo even with high initial strength. Degradation of certain polymers (PLA, PGA) creates a local acidic environment that can also cause adverse tissue responses. Currently, polyhydroxyalkanoate (PHA) is used in the electrospinning process, due to its excellent biocompatibility and biodegradability. The electrospinning parameters (e.g., voltage, flow rate, concentration and polymer molecular weight) can be varied in order to produce nanofibres with complex and unique three-dimensional shapes. This review includes electrospinning of PHA and its biomedical uses of PHA electrospun. Moreover, the future prospect of PHA electrospun was also recommended.
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