ผลกระทบจากการแปรรูปขั้นสูงและสารเติมแต่งในผลิตภัณฑ์เนื้อจากพืชต่อสุขภาพหัวใจและหลอดเลือด
Main Article Content
บทคัดย่อ
ผลิตภัณฑ์เนื้อจากพืช ได้รับความนิยมเพิ่มขึ้นจากการเป็นผลิตภัณฑ์ทางเลือกแทนเนื้อสัตว์ หลายงานวิจัยกล่าวถึงข้อดีของผลิตภัณฑ์เนื้อจากพืชว่าสมีผลดีต่อระดับไขมันในเลือดหรือดัชนีมวลกายเมื่อเทียบกับเนื้อสัตว์ อย่างไรก็ตามความกังวลเกี่ยวกับกระบวนการแปรรูปขั้นสูงอาจส่งผลกระทบต่อสุขภาพโดยเฉพาะอย่างยิ่ง โรคหัวใจและหลอดเลือด รวมถึงยังไม่มีการศึกษาหรือทบทวนวรรณกรรมที่เน้นวิเคราะห์ผลกระทบของวิธีการแปรรูปขั้นสูง และ การใช้สารเติมแต่งในผลิตภัณฑ์เนื้อจากพืชต่อสุขภาพหัวใจและหลอดเลือดโดยเฉพาะ ทั้งที่ผลิตภัณฑ์เนื้อจากพืชส่วนใหญ่จัดอยู่ในกลุ่มอาหารที่ผ่านการแปรรูปขั้นสูง โดยอาจลดทอนประโยชน์ที่คาดหวังไว้ วัตถุประสงค์ของการทบทวนนี้คือเพื่อรวบรวมและให้ข้อมูลผลกระทบของกระบวนการแปรรูปขั้นสูงในการผลิตภัณฑ์เนื้อจากพืชต่อสุขภาพหัวใจและหลอดเลือด เพื่อเป็นแนวทางในการพัฒนากระบวนการรวมถึงองค์ประกอบที่ปลอดภัยและเป็นธรรมชาติมากขึ้น เพื่อให้ส่วนผสมในผลิตภัณฑ์เนื้อจากพืช มีความปลอดภัยและป้องกันผลกระทบต่อสุขภาพตามมาได้ นอกจากนี้การศึกษาผลกระทบด้านสุขภาพในระยะยาวเป็นสิ่งสำคัญสำหรับการประเมินความเสี่ยงและประโยชน์ของผลิตภัณฑ์เนื้อจากพืช รวมถึงการพัฒนาสูตรที่มีคุณค่าทางโภชนาการสูง เช่น การลดโซเดียม และการเพิ่มธาตุเหล็ก วิตามินบี 12 และกรดไขมันโอเมก้า-3 เพื่อส่งเสริมสุขภาพหัวใจที่ดี
Article Details
เอกสารอ้างอิง
Xavier JR, Shashikumar SH, Vats D, et al. Future trends in plant-based meat: Consumer perception, market growth and health benefits. Fut Foods 2025; 11: 100551.
Vallikkadan MS, Dhanapal L, Dutta S, et al. Meat alternatives: evolution, structuring techniques, trends, and challenges. Food Eng Rev 2023; 15(2): 329–59.
Benković M, Jurinjak Tušek A, Sokač Cvetnić T, et al. An overview of ingredients used for plant-based meat analogue production and their influence on structural and textural properties of the final product. Gels 2023; 9(12): 921.
Bianchi F, Stewart C, Astbury NM, et al. Replacing meat with alternative plant-based products (RE-MAP): a randomized controlled trial of a multicomponent behavioral interven-tion to reduce meat consumption. Am J Clin Nutr 2022; 115(5): 1357–66.
Crimarco A, Springfield S, Petlura C, et al. A randomized crossover trial on the effect of plant-based compared with animal-based meat on trimethylamine-N-oxide and cardiovascular disease risk factors in generally healthy adults: study with appetizing plantfood—meat eating alternative trial (SWAP-MEAT). Am J Clin Nutr 2020; 112(5): 1188–99.
Crimarco A, Landry MJ, Carter MM, et al. Assessing the effects of alternative plant-based meats v. animal meats on biomarkers of inflammation: a secondary analysis of the SWAP-MEAT randomized crossover trial. J Nutr Sci 2022; 11: e82.
Fernández-Rodríguez R, Bizzozero-Peroni B, Díaz-Goñi V, et al. Plant-based meat alternatives and cardiometabolic health: a systematic review and meta-analysis. Am J Clin Nutr 2025; 121(2):274–83.
Rees Clayton EM, Specht EA, Welch DR, et al. Addressing global protein demand through diversification and innovation: an introduction to plant-based and clean meat. In: Melton L, Shahidi F, Varelis P, eds. Encyclopedia of Food Chemistry. Oxford: Academic Press, 2019: 209–17.
Ishaq A, Irfan S, Sameen A, et al. Plant-based meat analogs: a review with reference to formulation and gastrointestinal fate. Curr Res Food Sci 2022; 5: 973–83.
Langyan S, Yadava P, Khan FN, et al. Sustaining protein nutrition through plant-based foods. Front Nutr 2021; 8: 772573.
Allah B, Se-Jin L, Eun-Yeong L, et al. Traditional plant-based meat alternatives, current, and future perspective: a review. J Agric Life Sci 2021; 55(1): 1–11.
Amagliani L, O'Regan J, Kelly AL, et al. The composition, extraction, functionality and applications of rice proteins: a review. Trends Food Sci Technol 2017; 64: 1–12.
Coda R, Varis J, Verni M, et al. Improvement of the protein quality of wheat bread through faba bean sourdough addition. LWT Food Sci Technol 2017; 82: 296–302.
López DN, Galante M, Robson M, et al. Amaranth, quinoa and chia protein isolates: physicochemical and structural properties. Int J Biol Macromol 2018; 109: 152–59.
de Oliveira Sousa AG, Fernandes DC, Alves AM, et al. Nutritional quality and protein value of exotic almonds and nut from the Brazilian Savanna compared to peanut. Food Res Int 2011; 44(7): 2319–25.
Kyriakopoulou K, Keppler JK, van der Goot AJ, et al. Functionality of ingredients and additives in plant-based meat analogues. Foods 2021; 10(3): 600.
Geerts MEJ, Dekkers BL, van der Padt A, et al. Aqueous fractionation processes of soy protein for fibrous structure formation. Innov Food Sci Emerg Technol 2018; 45: 313–19.
Schreuders FKG, Dekkers BL, Bodnár I, et al. Comparing structuring potential of pea and soy protein with gluten for meat analogue preparation. J Food Eng 2019; 261: 32–39.
Wu H, Sakai K, Zhang J, et al. Plant-based meat analogs: color challenges and coloring agents. Food Nutr Health 2024; 1(1): 4.
Ahmad MI, Farooq S, Alhamoud Y, et al. Soy leghemoglobin: a review of its structure, production, safety aspects, and food applications. Trends Food Sci Technol 2023; 141: 104199.
Tzoneva RD, Mishonova-Alexova EI. A calorimetric study of pH-dependent thermal unfolding of leghemoglobin a from soybean. Biochim Biophys Acta Bioenerg 1998; 1364(3): 420–24.
FDA. FDA In Brief: FDA approves soy leghemoglobin as a color additive. 2025. Available at: https://www.fda.gov/news-events/fda-brief/fda-brief-fda-approves-soy-leghemoglobin-color-additive, accessed on Mar 25, 2025.
Ngamwonglumlert L, Sakamon D, Chiewchan N. Natural colorants: Pigment stability and extraction yield enhancement via utilization of appropriate pretreatment and extraction methods. Crit Rev Food Sci Nutr 2017; 57(15): 3243–59.
Sha L, Xiong YL. Plant protein-based alternatives of reconstructed meat: science, technology, and challenges. Trends Food Sci Technol 2020; 102: 51–61.
He J, Evans NM, Liu H, et al. A review of research on plant-based meat alternatives: driving forces, history, manufacturing, and consumer attitudes. Compr Rev Food Sci Food Saf 2020; 19(5):2639–56.
Tamanna N, Mahmood N. Food processing and maillard reaction products: effect on human health and nutrition. Int J Food Sci 2015; 2015: 526762.
Murata M. Browning and pigmentation in food through the maillard reaction. Glycoconj J 2021; 38(3): 283-92.
Hofmann T, Schieberle P. Evaluation of the key odorants in a thermally treated solution of ribose and cysteine by aroma extract dilution techniques. J Agric Food Chem 1995; 43(8): 2187–94.
Yoruk R, Marshall MR. Physicochemical properties and function of plant polyphenol oxidase: a review. J Food Biochem 2003; 27(5): 361–422.
Kale P, Mishra A, Annapure US. Development of vegan meat flavour: a review on sources and techniques. Future Foods 2022; 5: 100149.
Tomé D. Yeast extracts: nutritional and flavoring food ingredients. ACS Food Sci Technol 2021; 1(4): 487–94.
Lin M, Liu X, Xu Q, et al. Aroma-active components of yeast extract pastes with a basic and characteristic meaty flavour. J Sci Food Agric 2014; 94(5): 882–89.
Li X, Li J. The flavor of plant-based meat analogues. Cereal Foods World 2020; 65(4): 0040.
Liu J, Liu M, He C, et al. Effect of thermal treatment on the flavor generation from maillard reaction of xylose and chicken peptide. LWT Food Sci Technol 2015; 64(1): 316–25.
Fadel HH, Samad AA, Kobeasy M, et al. Flavour quality and stability of an encapsulated meat-like process flavouring prepared from soybean based acid hydrolyzed protein. Int J Food Process Technol 2015; 2(1): 17–25.
Bel-Rhlid R, Berger RG, Blank I. Bio-mediated generation of food flavors – towards sustainable flavor production inspired by nature. Trends Food Sci Technol 2018; 78: 134–43.
García-García R, Searle SS. Preservatives: Food use. In: Caballero B, Finglas PM, Toldrá F, eds. Encyclopedia of Food and Health. Oxford: Academic Press; 2016: 505–9.
Piper JD, Piper PW. Benzoate and sorbate salts: a systematic review of the potential hazards of these invaluable preservatives and the expanding spectrum of clinical uses for sodium benzoate. Compr Rev Food Sci Food Saf 2017; 16(5): 868–80.
Yu J, Wang L, Zhang Z. Plant-based meat proteins: processing, nutrition composition, and future prospects. Foods 2023; 12(22): 4180.
Hewage A, Olatunde OO, Nimalaratne C, et al. Novel extraction technologies for developing plant protein ingredients with improved functionality. Trends Food Sci Technol 2022; 129: 492–511.
Kumar M, Tomar M, Potkule J, et al. Advances in the plant protein extraction: Mechanism and recommendations. Food Hydrocoll 2021; 115: 106595.
Perović MN, Knežević Jugović ZD, Antov MG. Improved recovery of protein from soy grit by enzyme-assisted alkaline extraction. J Food Eng 2020; 276: 109894.
Cui Q, Ni X, Zeng L, et al. Optimization of protein extraction and decoloration conditions for tea residues. Hortic Plant J 2017; 3(4): 172–76.
Momen S, Alavi F, Aider M. Alkali-mediated treatments for extraction and functional modification of proteins: critical and application review. Trends Food Sci Technol 2021; 110: 778–97.
Jiang Y, Zhou X, Zheng Y, et al. Impact of ultrasonication/shear emulsifying/microwave-assisted enzymatic extraction on rheological, structural, and functional properties of Akebia trifoliata (Thunb.) Koidz. seed protein isolates. Food Hydrocoll 2021; 112: 106355.
Pojić M, Mišan A, Tiwari B. Eco-innovative technologies for extraction of proteins for human consumption from renewable protein sources of plant origin. Trends Food Sci Technol 2018; 75: 93–104.
Dong X-Y, Guo L-L, Wei F, et al. Some characteristics and functional properties of rapeseed protein prepared by ultrasonication, ultrafiltration and isoelectric precipitation. J Sci Food Agric 2011; 91(8): 1488–98.
Xia S, Shen S, Song J, et al. Physicochemical and structural properties of meat analogues from yeast and soy protein prepared via high-moisture extrusion. Food Chem 2023; 402: 134265.
Wild F, Czerny M, Janssen A, et al. The evolution of a plant-based alternative to meat: From niche markets to widely accepted meat alternatives. Agro Food Ind Hi Tech 2014; 25: 45–9.
Dankar I, Haddarah A, Omar FEL, et al. 3D printing technology: the new era for food customization and elaboration. Trends Food Sci Technol 2018; 75: 231–42.
Chen Y, Zhang M, Bhandari B. 3D printing of steak-like foods based on textured soybean protein. Foods 2021; 10(9): 2011.
Shi Z, Blecker C, Richel A, et al. Three-dimensional (3D) printability assessment of food-ink systems with superfine ground white common bean (Phaseolus vulgaris L.) protein based on different 3D food printers. LWT 2022; 155: 112906.
Krintiras GA, Göbel J, van der Goot AJ, et al. Production of structured soy-based meat analogues using simple shear and heat in a Couette Cell. J Food Eng 2015; 160: 34–41.
Cui B, Liang H, Li J, et al. Development and characterization of edible plant-based fibers using a wet-spinning technique. Food Hydrocoll 2022; 133: 107965.
Lin X, Cao Z, Zhang J, et al. Characteristics of the mixed yogurt fermented from cow-soy milk in the presence of transglutaminase. Foods 2024; 13(13): 2120.
Schlegel K, Sontheimer K, Hickisch A, et al. Enzymatic hydrolysis of lupin protein isolates—Changes in the molecular weight distribution, technofunctional characteristics, and sensory attributes. Food Sci Nutr 2019; 7(8): 2747–59.
Wang Y, Tuccillo F, Lampi A-M, et al. Flavor challenges in extruded plant-based meat alternatives: A review. Compr Rev Food Sci Food Saf 2022; 21(3): 2898–929.
Yan S, Xu J, Zhang X, et al. Effect of pH-shifting treatment on the structural and functional properties of soybean protein isolate and its interactions with (–)-epigallocatechin-3-gallate. Process Biochem 2021; 101: 190–98.
Ismail I, Hwang YH, Joo ST. Meat analog as future food: a review. J Anim Sci Technol 2020; 62(2): 111–20.
Andreani G, Sogari G, Marti A, et al. Plant-based meat alternatives: technological, nutritional, environmental, market, and social challenges and opportunities. Nutrients 2023; 15(2): 452.
Metz KM, Neumann NJ, Fasshauer M. Ultra-processing markers are more prevalent in plant-based meat products as compared to their meat-based counterparts in a German food market analysis. Public Health Nutr 2023; 26(12): 2728–37.
Vale C, Almeida C, Azevedo J, et al. Nutrient profile of packaged foods according to the degree of processing. Int J Food Sci Nutr 2024; 75(2): 148–58.
Cutroneo S, Angelino D, Tedeschi T, et al. Nutritional quality of meat analogues: results from the food labelling of Italian products (FLIP) project. Front Nutr 2022; 9: 852831.
Cole E, Natalie G-S, Allison C, et al. Examination of the nutritional composition of alternative beef burgers available in the United States. Int J Food Sci Nutr 2022; 73(4): 425–32.
Bryngelsson S, Hanieh M, Marta B, et al. Nutritional assessment of plant-based meat analogues on the Swedish market. Int J Food Sci Nutr 2022; 73(7): 889–901.
Tso R, Forde CG. Unintended consequences: nutritional impact and potential pitfalls of switching from animal- to plant-based foods. Nutrients 2021; 13(8): 2527.
Tangyu M, Muller J, Bolten CJ, et al. Fermentation of plant-based milk alternatives for improved flavour and nutritional value. Appl Microbiol Biotechnol 2019; 103(23): 9263–75.
Pointke M, Pawelzik E. Plant-based alternative products: are they healthy alternatives? Micro- and macronutrients and nutritional scoring. Nutrients 2022; 14(3): 601.
Mistry K, Sardar SD, Alim H, et al. Plant based proteins: sustainable alternatives. Plant Sci Today 2022; 9(4): 820–28.
Ramos-Diaz JM, Kantanen K, Edelmann JM, et al. Functionality of oat fiber concentrate and faba bean protein concentrate in plant-based substitutes for minced meat. Curr Res Food Sci 2022; 5: 858–67.
Twarogowska A, Van Droogenbroeck B, Fraeye I. Application of Belgian endive (Cichorium intybus var. foliosum) dietary fiber concentrate to improve nutritional value and functional properties of plant-based burgers. Food Biosci 2022; 48: 101825.
Flint M, Bowles S, Lynn A, et al. Novel plant-based meat alternatives: future opportunities and health considerations. Proc Nutr Soc 2023; 82(3): 370–85.
Guo Z, Teng F, Huang Z, et al. Effects of material characteristics on the structural characteristics and flavor substances retention of meat analogs. Food Hydrocoll 2020; 105: 105752.
Ran X, Lou X, Zheng H, et al. Improving the texture and rheological qualities of a plant-based fishball analogue by using konjac glucomannan to enhance crosslinks with soy protein. Innov Food Sci Emerg Technol 2022; 75: 102910.
M Y, Sunil CK, Sahana S, et al. Protein-based fat replacers – a review of recent advances. Food Rev Int 2021; 37(2): 197–223.
Farsi DN, Uthumange D, Munoz Munoz J, et al. The nutritional impact of replacing dietary meat with meat alternatives in the UK: a modelling analysis using nationally representative data. Br J Nutr 2022; 127(11): 1731–41.
Schmid E-M, Farahnaky A, Adhikari B, et al. High moisture extrusion cooking of meat analogs: a review of mechanisms of protein texturization. Compr Rev Food Sci Food Saf 2022; 21(6): 4573–609.
Brennan C, Brennan M, Derbyshire E, et al. Effects of extrusion on the polyphenols, vitamins and antioxidant activity of foods. Trends Food Sci Technol 2011; 22(10): 570–75.
Fresán U, Mejia MA, Craig WJ, et al. Meat analogs from different protein sources: a comparison of their sustainability and nutritional content. Sustainability 2019; 11(12): 3231.
De Marchi M, Costa A, Pozza M, et al. Detailed characterization of plant-based burgers. Sci Rep 2021; 11(1): 2049.
Cheng X, et al. Advances in protein extraction techniques and their impact on food hydrocolloids. Food Hydrocoll 2021; 112: 106519.
Uribarri J, Woodruff S, Goodman S, et al. Advanced glycation end products in foods and a practical guide to their reduction in the diet. J Am Diet Assoc 2010; 110(6): 911–16.
Poulsen MW, Hedegaard RV, Andersen JM, et al. Advanced glycation endproducts in food and their effects on health. Food Chem Toxicol 2013; 60: 10–37.
Barba FJ, Esteve MJ, Frígola A. Advanced glycation end products in food and their effects on health. Trends Food Sci Technol 2015; 45(2): 158–69.
Sun Y, Bai X, Zhang Z, et al. Dietary advanced glycation end products and their health implications: a review. Trends Food Sci Technol 2018; 75: 88–97.
Godoi FC, Prentice C, Varela F, et al. 3D printing technologies applied to food: status and prospects. J Food Eng 2016; 179:44–54.
Srour B, Chazelas E, Fezeu LK, et al. Nitrites, nitrates, and cardiovascular outcomes: are we living “la vie en rose” with pink processed meats? J Am Heart Assoc 2022; 11(24): e027627.
Rauber F, Laura da Costa Louzada M, Chang K, et al. Implications of food ultra-processing on cardiovascular risk considering plant origin foods: an analysis of the UK Biobank cohort. Lancet Reg Health Eur 2024; 43: 100948.
Vitale M, Costabile G, Testa R, et al. Ultra-processed foods and human health: a systematic review and meta-analysis of prospective cohort studies. Adv Nutr 2024; 15(1): 100121.
Barbosa SS, Sousa LCM, de Oliveira Silva DF, et al. A systematic review on processed/ultra-processed foods and arterial hypertension in adults and older people. Nutrients 2022; 14(6): 1215.
Liu C, Shi J, Wang J, et al. Effects of different processing degrees of plant-based meat on the blood biochemical level, inflammation and intestinal microorganisms in mice. Food Res Int 2023; 173: 113398.
Sellem L, Srour B, Javaux G, et al. Food additive emulsifiers and risk of cardiovascular disease in the NutriNet-Santé cohort: prospective cohort study. BMJ 2023; 382: e076058.
Srour B, Fezeu LK, Kesse-Guyot E, et al. Ultra-processed food intake and risk of cardiovascular disease: prospective cohort study (NutriNet-Santé). BMJ 2019; 365: l1451.
Bonaccio M, Costanzo S, Di Castelnuovo A, et al. Ultra-processed food intake and all-cause and cause-specific mortality in individuals with cardiovascular disease: the Moli-sani Study. Eur Heart J 2022; 43(3): 213–24.
Lane MM, Gamage E, Du S, et al. Ultra-processed food exposure and adverse health outcomes: umbrella review of epidemiological meta-analyses. BMJ 2024; 384: e077310.
Mensink RP and World Health Organization. Effects of saturated fatty acids on serum lipids and lipoproteins: a systematic review and regression analysis. World Health Organization. 2016. 72 p. Available at https://iris.who.int/handle/10665/246104, accessed on Feb 5, 2025.
Bancil AS, Sandall AM, Rossi M, et al. Food additive emulsifiers and their impact on gut microbiome, permeability, and inflammation: mechanistic insights in inflammatory bowel disease. J Crohns Colitis 2021; 15(6): 1068–79.
Naimi S, Viennois E, Gewirtz AT, et al. Direct impact of commonly used dietary emulsifiers on human gut microbiota. Microbiome 2021; 9: 66.
EFSA panel on food additives and nutrient sources added to food. Re-evaluation of phosphates as food additives. EFSA J 2019; 17(6): e05674.
Raoul P, Cintoni M, Palombaro M, et al. Food additives, a key environmental factor in the development of IBD through gut dysbiosis. Microorganisms 2022; 10: 167.