Cyclic Voltammetric Determination of Acetaminophen in Paracetamol Tablets

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Published: Mar 30, 2018
Keywords:
Acetaminophen, paracetamol, cyclic voltammetry, glassy carbon electrode

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Kanita Tungkananuruk*
Department of Chemistry, King Mongkut’s Institute of Technology Lardkrabang, Bangkok, Thailand
Nipon Tungkananuruk
College of Environment, Kasetsart University, Bangkok Thailand
Duncan Thorburn Burns
Department of Analytical Chemistry, The Queen’s University of Belfast, UK

Abstract

A method using cyclic voltammetry has been developed for the determination of acetaminophen in paracetamol tablets. The peak current from acetaminophen in 0.10 mol L-1 phosphate buffer pH 7.0 was measured with a glassy carbon electrode versus Ag/AgCl. The optimum step potential and scan rate were found to be 0.0005 V and 0.1000 V/s, respectively. The linear calibration range was 3-240 μg ml-1, and the detection limit and recovery were 3.0 μg ml-1 and 99.1% respectively. The results have been compared with those obtained by the USP XXII official method.


Keywords: Acetaminophen, paracetamol, cyclic voltammetry, glassy carbon electrode


Corresponding author: E-mail: Niponniyuta@yahoo.com

Article Details

Issue
Vol. 5 No. 3 (2005)
Section
Original Research Articles

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