Cyclic Voltammetric Determination of Acetaminophen in Paracetamol Tablets

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Kanita Tungkananuruk*
Nipon Tungkananuruk
Duncan Thorburn Burns

Abstract

A method using cyclic voltammetry has been developed for the determination of acetaminophen in paracetamol tablets. The peak current from acetaminophen in 0.10 mol L-1 phosphate buffer pH 7.0 was measured with a glassy carbon electrode versus Ag/AgCl. The optimum step potential and scan rate were found to be 0.0005 V and 0.1000 V/s, respectively. The linear calibration range was 3-240 μg ml-1, and the detection limit and recovery were 3.0 μg ml-1 and 99.1% respectively. The results have been compared with those obtained by the USP XXII official method.


Keywords: Acetaminophen, paracetamol, cyclic voltammetry, glassy carbon electrode


Corresponding author: E-mail: [email protected]

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Original Research Articles

References

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