Transmission Model of Dengue Disease with The Appearance of Symptom

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Puntani Pongsumpun*
Decha Samana

Abstract

Dengue virus is transmitted to the human by biting of the infected Aedes Aegypti mosquito. After infection with dengue virus, the people may be symptomatic or asymptomatic. This fact is studied through the mathematical model. The infectious population with symptom and no symptom classes are introduced into the modified model. We compare this model with the SIR (Susceptible-Infectious-Recovered) model. The standard dynamical analysis is used to analyze the behavior of the solutions for the two models. A new expression for the basic reproduction rate is obtained. It is found that the symptomatic and asymptomatic classes reduce the periods of oscillations in the susceptible human, Infectious human and infectious vector and the tightness of the spiraling into the endemic equilibrium state.


Keywords: transmission model, dengue disease, SIR model, symptomatic infection, asymptomatic infection


Corresponding author: E-mail: kppuntan@kmitl.ac.th

Article Details

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Original Research Articles

References

[1] World Health Organization, 1997 Dengue Haemorrhagic Fever: Diagnosis treatment and control, Geneva.
[2] Burke, D.S., Nisalak, A., Johnson, D. and Scott, R.M. 1988 A Prospective Study of Dengue Infections in Bangkok, Am. J. Trop. Med. Hyg. 38, 172-180.
[3] Kuri, G., Mas, P., Soler, M. and Goyenechea, A. 1983 Dengue Hemorrhagic Fever in Cuba, 1981: Rapid Diagnosis of the Etiologic Agent. Bull. Pan. Am. Health. Org. 17, 126-132.
[4] Esteva, L. and Vargas, C. 1998 Analysis of a Dengue Disease Transmission Model. Mathematical Biosciences, 150, 131-151.
[5] Robert, M. 1973 Stability and Complexity in Model Ecosystem, Princeton University Press.
[6] Hethcote, H.W. 2000 The Mathematics of Infectious Disease. Siam Review, 42, 599-653.
[7] Kuno, G. 1995 Review of the Factors Modulating Dengue Transmission. Epidemiology Review, 17, 321-335.
[8] Gubler, D.J. 1998 Dengue and Dengue Hemorrhagic Fever. Clinical Microbiology Review, 11, 450-496.
[9] Esteva, L. and Vargas, C. 2000 Influence of Vertical and Mechanical Transmission on the Dynamics of Dengue Disease Mathematical Biosciences, 167, 51-64.
[10] Leah, E.K. 1988 Mathematical Models in Biology, Random House, Inc.