Antibacterial Activity of Pregnenolone Derivatives

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Published: Mar 30, 2018
Keywords:
steroids; antibacterial activity; Disc diffusion method; pregnenolone

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Wanawan Prabpayak
Department of Chemistry, Faculty of Science, King Mongkut’s Institute of Technology Ladkrabang, Bangkok, Thailand.
Patchanee Charoenying*
Department of Chemistry, Faculty of Science, King Mongkut’s Institute of Technology Ladkrabang, Bangkok, Thailand.
Chamroon Laosinwattana
Department of Horticulture, Faculty of Agricultural Technology, King Mongkut’s Institute of Technology Ladkrabang, Bangkok, Thailand.
Nuntana Aroonrerk
Department of Stomatology, Faculty of Dentistry, Srinakharinwirot University, Bangkok, Thailand.

Abstract

Four new synthesized steroids, 3β-alloxy-5-pregnene-20-one 4, 3β-alloxy-5-pregene-17-oxime 5, 3β-stearoate-5-pregnene-20-one 6, 3β-stearoate-5pregnene-17-oxime 7, have been synthesized starting from 3β-hydroxy-5pregnene-20-one 3. The structures of theses steroids were confirmed by analytical and spectroscopic evidence. All of compounds were examined for antibacterial activity in vitro using the disc diffusion method.


Keywords: steroids; antibacterial activity; Disc diffusion method; pregnenolone


Corresponding author: E-mail: kcpatcha@kmitl.ac.th


 

Article Details

Issue
Vol. 6 No. 2b (2006)
Section
Original Research Articles

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