Antibacterial Activity of Pregnenolone Derivatives
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Abstract
Four new synthesized steroids, 3β-alloxy-5-pregnene-20-one 4, 3β-alloxy-5-pregene-17-oxime 5, 3β-stearoate-5-pregnene-20-one 6, 3β-stearoate-5pregnene-17-oxime 7, have been synthesized starting from 3β-hydroxy-5pregnene-20-one 3. The structures of theses steroids were confirmed by analytical and spectroscopic evidence. All of compounds were examined for antibacterial activity in vitro using the disc diffusion method.
Keywords: steroids; antibacterial activity; Disc diffusion method; pregnenolone
Corresponding author: E-mail: kcpatcha@kmitl.ac.th
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