The Anti-Diabetic Effect of Nano-Encapsulated Propolis from Apis mellifera on Type 2 Diabetes

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Sarah S. Hegazy*
Hanan Helmy
Mohamad S. Salama
Nadia M. Lotfy
Dalia M. Mahmoud


Diabetes mellitus is viewed as a major disease and is among the most prevalent health problems globally. The goal of the present research was to evaluate the therapeutic efficiency of an ethanolic extract of Egyptian propolis (EEP) conjugated with chitosan polyacrylic (CS-PAA) nanoparticles against type 2 diabetes mellitus. Thirty Wistar rats were randomly categorized into 6 groups (5 animals/ group). Group I consisted of normal rats as a normal control. The remaining five groups were injected with streptozotocin (STZ), a diabetogenic agent, in order to induce diabetes. The experimental groups were treated for 4 consecutive weeks as follows: Group II included untreated diabetic rats, serving as a negative control. Group III consisted of diabetic rats treated with EEP. Group VI consisted of diabetic rats treated with Metformin. The findings of this work illustrated that no significant differences were noticed concerning the body weight of the treated groups compared to that of the normal control group. Blood glucose levels were significantly decreased in the diabetic rats treated with EEP and EEP encapsulated CS-PAA nanoparticles compared to the untreated diabetic rats.  The results indicated that EEP encapsulated CS-PAA nanoparticles displayed a potential therapeutic effect against type 2 diabetes mellitus.


Keywords: diabetes mellitus; chitosan, polyacrylic acid; propolis; body weight

*Corresponding author: Tel.: (+20) 100 494 2997



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