Identification, Epidemiology and Seasonal Variation of Neisseria meningitidis in Al-Nasiriya City, South of Iraq
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Abstract
The study involved 219 meningitis patients registered at AL-Hussein Teaching Hospital over a two-year period to determine the prevalence of Neisseria meningitidis in AL-Nasiriya city and the impact of sociodemographic parameters on infection (from the beginning of 2015 to the end of 2016). A technician extracted cerebrospinal fluid samples from the research population, and then transferred them directly to the laboratory for the identification of bacterial pathogens. The findings revealed that 57 patients (26.02%) were afflicted with Neisseria meningitidis. Twenty-nine cases (50.87%) were in 2015 and 28 cases (49.13%) were in 2016. Our studies showed that the incidence of Neisseria meningitidis was slightly higher in males than in females and in the age group of 20-44 years old. Over the study period, seasonal variation was also shown. This study concluded that meningococcal meningitis infection was affected by sociodemographic influences, which appeared to be prevalent in the long warm seasons of Iraqi weather, with summer having the highest percentage of N. meningitidis infections, followed by fall.
Keywords: meningitis; sociodemographic factors; Neisseria meningitidis; seasonality
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References
Saez-Llorens, X. and McCracken, G.H., 1990. Bacterial meningitis in neonates and children. Infectious Disease Clinics of North America, 4(4), 623-644.
Celal, A., Faruk, G.M., Salih, H., Kemal, C.M., Serife, A. and Faruk, K.O., 2004. Characteristics of acute bacterial meningitis in Southeast Turkey. Indian Journal of Medical Sciences, 58(8), 327-333.
Munguambe, A.M., Almeida, A.E.C.C., Nhantumbo, A.A., Come, E.C., Zimba, T.F., Langa, J.P., Filippis, I. and Gudo, E.S., 2018. Characterization of strains of Neisseria meningitidis causing meningococcal meningitis in Mozambique, 2014: Implications for vaccination against meningococcal meningitis. PloS One 13(8), e0197390, https://doi.org/10.1371/journal.pone.0197390.
World Health Organization, 1998. Control of Epidemic Meningococcal Disease: WHO Practical Guidelines. [online] Available at: https://apps.who.int/iris/handle/10665/64467.
Rouphael, N.G. and Stephens, D.S., 2012. Neisseria meningitidis: biology, microbiology, and epidemiology. Methods in Molecular Biology, 799, 1-20.
World Health Organization and Center for Disease Control and Prevention, 2011. Laboratory Methods for the Diagnosis of Meningitis Caused by Neisseria meningitidis, Streptococcus pneumoniae, and Haemophilus influenzae: WHO Manual. [online] Available at: https://apps.who.int/iris/handle/10665/70765.
World Health Organization, 2003. The World Health Report: 2003: Shaping the Future. World Health Organization. [online]. Available at: http://www.who.int/whr/2003/en/.
Baron, E.J., Pererson, L.R. and Finegold, S.M., 1994. Bailey and Scott's Diagnostic Microbiology. 9th ed. St. Louis: Mosby.
Saadi, A.T., Garjees, N.A. and Rasool A.H., 2017. Antibiogram profile of septic meningitis among children in Duhok, Iraq. Saudi Medical Journal, 38(5), 517-520.
Razak, A.A., Atheer, Al-Mathkhury, H.J.F., Jasim, K.A., Saber, M.Q. and Al-Shammari, A.J.N., 2013. Prevalence of Neisseria meningitidis in Iraqi children presented with meningitis. International Journal for Sciences and Technology, 8(1), 62-66.
Gurley, E.S., Hossain, M.J., Montgomery, S.P., Petersen, L.R., Sejvar, J.J., Mayer, L.W., Whitney, A., Dull, P., Nahar, N., Uddin, A. K., Rahman, M.E., Ekram, A.R., Luby, S.P. and Breiman, R.F., 2009. Etiologies of bacterial meningitis in Bangladesh: Results from a hospital-based study. The American Journal of Tropical Medicine and Hygiene, 81(3), 475-483.
Fish, E.N., 2008. The X-files in immunity: sex-based differences predispose immune responses. Nature Reviews Immunology, 8(9), 737-744.
Fischer, J., Jung, N., Robinson, N. and Lehmann, C., 2015. Sex differences in immune responses to infectious diseases. Infection, 43(4), 399-403.
Doran, K.S., Fulde, M., Gratz, N., Kim, B.J., Nau, R., Prasadaro, N., Schubert-Unkmeir, A., Tuomanen, E.I. and Valentin-Weigand, P., 2016. Host-pathogen interactions in bacterial meningitis. Acta Neuropathologica, 131(2), 185-209.
Al-Mazrou, Y.Y., Musa, E.K., Abdalla, M.N., Al-Jeffri, M.H. and Al-Hajar, S.H., 2003. Disease burden and case management of bacterial meningitis among children under 5 years of age in Saudi Arabia. Saudi Medical Journal, 24, 1300-1307.
Sallam, A.K., 2004. Etiology and presentation of acute bacterial meningitis in children at Al- Thawrah hospital, Sanna'a, Yemen. Journal of Ayub Medical College Abbottabad, 16, 40-43.
Schuchat, A., Robinson, K. and Wenger, J.D., 1997. Bacterial meningitis in the United States in 1995. Active Surveillance Team. The New England Journal of Medicine, 337, 970-976.
Pollard, A.J., Perrett, K.P. and Beverley, P.C., 2009. Maintaining protection against invasive bacteria with protein-polysaccharide conjugate vaccines. Nature Reviews Immunology, 9(3), 213-220.
European Centre for Disease Prevention and Control (ECDC), 2014. Annual Epidemiological Report. Vaccine-preventable Diseases-Invasive Bacterial Diseases 2014. [online] Available at: https://www.ecdc.europa.eu/sites/portal/files/media/en/publications/Publications/AER-VPD-IBD-2014.pdf.
Mueller, J.E. and Gessner, B.D., 2009. A hypothetical explanatory model for meningococcal meningitis in the African meningitis belt. International Journal of Infectious Diseases, 14(7), e553-e559.
Moore, P.S., 1992. Meningococcal meningitis in sub-Saharan Africa: a model for the epidemic process. Clinical Infectious Diseases, 14, 515-525.
Paireau, J., Chen, A., Broutin, H., Grenfell, B. and Basta, N.E., 2016. Seasonal dynamics of bacterial meningitis: a time-series analysis. The Lancet Global Health, 4(6), e370-e377.
Dias, S.P., Brouwer, M.C., Bijlsma, M.W., Ende, A. and Beek, D., 2017. Sex-based differences in adults with community-acquired bacterial meningitis: a prospective cohort study. Clinical Microbiology and Infection, 23(2), 121-e9-121.e15.
Chaves-Bueno, S. and McCracken, G.H., 2005. Bacterial meningitis in children. Pediatric Clinics of North America, 52(3), 795-810.