Preparation and Characterization of Porous Natural Rubber Loaded with Silver Nanoparticles
Article Sidebar
Main Article Content
Abstract
In this study, porous natural rubber (NR) films loaded with silver nanoparticles (AgNPs) were prepared by the solvent casting method. The porous structure of the NR films was formed with hydrophilic substances such as glycerol, pectin or carrageenan. The film properties including morphology, mechanical test, hydrophilicity evaluation, water absorption, release study, and antibacterial activity were determined. From the results, the morphology of films was a continuous porous structure on the surface of films. The pectin and carrageenan enhanced porosity, hydrophilicity, and water sorption of the porous NR films. The developed porous NR films could sustain the release of Ag+ ions for 2 days and showed inhibition zones against Staphylococcus aureus and Escherichia coli. Therefore, these porous NR films have the potential to be used as chronic wound dressing.
Keywords: natural rubber; porous film; silver nanoparticle; pectin; carrageenan
*Corresponding author: Tel.: (+66) 53916787 Fax: (+66) 53916776
E-mail: [email protected]
Article Details
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Copyright Transfer Statement
The copyright of this article is transferred to Current Applied Science and Technology journal with effect if and when the article is accepted for publication. The copyright transfer covers the exclusive right to reproduce and distribute the article, including reprints, translations, photographic reproductions, electronic form (offline, online) or any other reproductions of similar nature.
The author warrants that this contribution is original and that he/she has full power to make this grant. The author signs for and accepts responsibility for releasing this material on behalf of any and all co-authors.
Here is the link for download: Copyright transfer form.pdf
References
Boateng, J. and Catanzano, O., 2015. Advanced therapeutic dressings for effective wound healing-a review. Journal of Pharmaceutical Sciences, 104(11), 3653-3680,
DOI: 10.1002/jps.24610.
Singer, A.J. and Clark, R.A., 1999. Cutaneous wound healing. New England Journal of Medicine, 341(10), 738-746, DOI: 10.1056/NEJM199909023411006.
Lin, Y.K., Matsumoto, Y., Kuroyanagi, Y. and Kagawa, S., 2009. A bilayer hyaluronic acid wound dressing to promote wound healing in diabetic ulcer. Journal of Bioactive and Compatible Polymers, 24(5), 424-443, DOI: 10.1177/0883911509341161.
Koehler, J., Brandl, F.P. and Goepferich, A.M., 2018. Hydrogel wound dressings for bioactive treatment of acute and chronic wounds. European Polymer Journal, 100, DOI: 10.1016/j.eurpolymj.2017.12.046.
Anderson, K. and Hamm, R.L., 2012. Factors that impair wound healing. Journal of the American College of Clinical Wound Specialists, 4(4), 84-91, DOI: 10.1016/j.jccw. 2014.03.001.
James, G.A., Swogger, E., Wolcott, R., Pulcini, E.D., Secor, P., Sestrich, J., Costerton, J.W., and Stewart, P.S., 2008. Biofilms in chronic wounds. Wound Repair and regeneration, 16(1), 37-44, DOI: 10.1111/j.1524-475X.2007.00321.x.
Boateng, J.S., Matthews, K.H., Stevens, H.N. and Eccleston, G.M., 2008. Wound healing dressings and drug delivery systems: a review. Journal of Pharmaceutical Sciences, 97(8), 2892-2923, DOI: 10.1002/jps.21210.
Phaechamud, T., Issarayungyuen, P. and Pichayakorn, W., 2016. Gentamicin sulfate-loaded porous natural rubber films for wound dressing. International Journal of Biological Macromolecules, 85, 634-644, DOI: 10.1016/j.ijbiomac.2016.01.040.
Santamaria, N., Gerdtz, M., Liu, W., Rakis, S., Sage, S., Ng, A., Tudor, H., MacCan, J., Vassiliou, T., Morrow, F., Smith, K., Knott, J. and Liew, D., 2015. Clinical effectiveness of a silicone foam dressing for the prevention of heel pressure ulcers in critically ill patients: Border II Trial. Journal of Wound Care, 24(8), 340-345, DOI: 10.12968/jowc.2015.24.8.340.
Kamińska, M.S., Cybulska, A.M., Skonieczna-Żydecka, K., Augustyniuk, K., Grochans, E. and Karakiewicz, B., 2020. Effectiveness of hydrocolloid dressings for treating pressure ulcers in adult patients: a systematic review and meta-analysis. International Journal of Environmental Research and Public Health, 17(21), DOI: 10.3390/ijerph17217881.
Stoica, A.E., Chircov, C. and Grumezescu, A.M., 2020. Hydrogel dressings for the treatment of burn wounds: an up-to-date overview. Materials, 13(12), DOI: 10.3390/ma13122853.
Pichayakorn, W., Suksaeree, J., Boonme, P., Amnuaikit, T., Taweepreda, W. and Ritthidej, G.C., 2012. Nicotine transdermal patches using polymeric natural rubber as the matrix controlling system: effect of polymer and plasticizer blends. Journal of Membrane Science, 411, 81-90, DOI: 10.1016/j.memsci.2012.04.017.
Rahimi, A. and Mashak, A., 2013. Review on rubbers in medicine: natural, silicone and polyurethane rubbers. Plastics, Rubber and Composites, 42(6), 223-230, DOI: 10.1179/1743289811Y.0000000063.
Phaechamud, T., Lertsuphotvanit, N., Issarayungyuen, P. and Chantadee, T., 2019. Design, fabrication and characterization of xanthan gum/liquid-loaded porous natural rubber film. Journal of Pharmaceutical Investigation, 49(1), 149-160, DOI: 10.1007/s40005-018-0396-2.
Savadekar, N.R., Karande, V.S., Vigneshwaran, N., Bharimalla, A.K. and Mhaske, S.T., 2012. Preparation of nano cellulose fibers and its application in kappa-carrageenan based film. International Journal of Biological Macromolecules, 51(5), 1008-1013, DOI: 10.1016/j.ijbiomac.2012.08.014.
Sedayu, B.B., Cran, M.J. and Bigger, S.W., 2019. A review of property enhancement techniques for carrageenan-based films and coatings. Carbohydrate Polymers, 216, 287-302, DOI: 10.1016/j.carbpol.2019.04.021.
Bagal‐Kestwal, D.R., Pan, M.H. and Chiang, B.H., 2019. Properties and applications of gelatin, pectin, and carrageenan gels. Bio Monomers for Green Polymeric Composite Materials, 117-140, DOI: 10.1002/9781119301714.ch6.
Alam, J., Alhoshan, M., Shukla, A.K., Aldalbahi, A. and Ali, F.A.A., 2019. k-Carrageenan-a versatile biopolymer for the preparation of a hydrophilic PVDF composite membrane. European Polymer Journal, 120, DOI: 10.1016/j.eurpolymj.2019.109219.
Li, D.Q., Li, J., Dong, H.L., Li, X., Zhang, J.Q., Ramaswamy, S. and Xu, F., 2021. Pectin in biomedical and drug delivery applications: a review. International Journal of Biological Macromolecules, 185, 49-65, DOI: 10.1016/j.ijbiomac.2021.06.088.
Gunasekaran, T., Nigusse, T. and Dhanaraju, M.D., 2011. Silver nanoparticles as real topical bullets for wound healing. Journal of the American College of Clinical Wound Specialists, 3(4), 82-96, DOI: 10.1016/j.jcws.2012.05.001.
Rheima, A.M., Mohammed, M.A., Jaber, S.H. and Hameed, S.A., 2019. Synthesis of silver nanoparticles using the UV-irradiation technique in an antibacterial application. Journal of Southwest Jiaotong University, 54(5), DOI: 10.35741/issn.0258-2724.54.5.34.
Nešović, K., Janković, A., Radetić, T., Vukašinović-Sekulić, M., Kojić, V., Živković, L., Perić-Gruji, A., Rhee, K.Y. and Mišković-Stanković, V., 2019. Chitosan-based hydrogel wound dressings with electrochemically incorporated silver nanoparticles-in vitro study. European Polymer Journal, 121, DOI: 10.1016/j.eurpolymj.2019.109257.
Pankongadisak, P., Ruktanonchai, U.R., Supaphol, P. and Suwantong, O., 2015. Development of silver nanoparticles‐loaded calcium alginate beads embedded in gelatin scaffolds for use as wound dressings. Polymer International, 64(2), 275-283, DOI: 10.1002/pi.4787.
Bressan, E., Ferroni, L., Gardin, C., Rigo, C., Stocchero, M., Vindigni, V., Vindigni, V. and Zavan, B., 2013. Silver nanoparticles and mitochondrial interaction. International Journal of Dentistry, 2013, DOI: 10.1155/2013/312747.
Bakar, N.A., Ismail, J. and Bakar, M.A., 2007. Synthesis and characterization of silver nanoparticles in natural rubber. Materials Chemistry and Physics, 104(2-3), 276-283, DOI: 10.1016/j.matchemphys.2007.03.015.
Naseri-Nosar, M. and Ziora, Z.M., 2018. Wound dressings from naturally-occurring polymers: a review on homopolysaccharide-based composites. Carbohydrate Polymers, 189, 379-398, DOI: 10.1016/j.carbpol.2018.02.003.