Hydrogel Formulation from Sugar Palm Starch as an Application of Acne Patch
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Abstract
Acne patches are among the most popular acne treatments. These patches are used to protect lesions from contaminants and deliver active compounds to enhance healing. In this study, hydrogel-based acne patches from sugar palm starch reinforced with chitosan (FC1-TTO) or alginate (FA1-TTO) were developed. Citric acid was used as a crosslinking agent, glycerol as a plasticizer, and tea tree oil (TTO) as the anti-acne agent. The hydrogel patches, containing 50, 70, and 100 µg/mL of TTO, were characterized using the FTIR, SEM, UTM, and DSC techniques. Their performance was evaluated based on encapsulation efficiency, drug release, and antibacterial properties. Both types of hydrogels containing 100 µg/mL of TTO showed high antibacterial activity against Cutibacterium acnes, Staphylococcus aureus, and Staphylococcus epidermidis, with inhibition zones up to 15 mm. Encapsulation efficiencies reached 95.98±0.24% for the FC1-TTO and 95.49±0.35% for the FA1-TTO. The cumulative TTO release after 6 h was 64.14% for the FC1-TTO and 85.08% for the FA1-TTO, indicating sustained release in both cases. In conclusion, sugar palm starch-based hydrogels reinforced with chitosan or alginate and loaded with 100 µg/mL TTO demonstrated effective antibacterial activity, making them a promising option for acne treatment.
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