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Mast cell tumors are the most common skin tumors of dog. Their appearance and biological behavior are variable, leading to frequent failure in treatment. Most mast cell tumors are routinely diagnosed by cytological and histological examination base on their morphological and staining characteristics. Others histochemical staining can give more information about their specific staining and enzyme activity. However, poorly differentiated mast cell tumors can be confused with other round cell tumors. Misdiagnosis and failure to identify the tumors might be circumstance. Immunohistochemistry has been used as an adjunct in the diagnosis and prognosis of neoplasms, including mast cell tumors. This article reviews the features of canine cutaneous mast cell tumors, as well as various histochemical and immunohistochemical stains used for their capability to diagnosis and prognosis. Together with clinical information and other prognostic indicators, these will support treatment planning and tumor monitoring properly.
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