Acute Phase Proteins Reaction in Ruminants

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Patipan Jaipeng
Leenawat Sukasem


When body tissue injury is happened from various causes such as many pathogens and abnormal cells, inflammatory response is basic mechanism against those pathogens. In the first time of inflammatory reaction, acute phase response or acute phase reaction was stimulated in this time with secretion of substances at acute phase. Acute phase reaction is complicate process and many body cell coordinate in this reaction. Acute phase proteins change within a few hours after stimulation from pathogens, including various substances connecting with disease cause in several body systems of ruminants. This reaction represents to inflammatory response of body which quick response than hematological change. This review article aims to gather information about deviation of some protein amounts responding to acute phase reaction of inflammation in ruminants for further researches.


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Alsemgeest, S.P.M., Lambooy, I.E., Wierenga, H.K., Dieleman, S.J., Meerkerk, B., van Ederen, A.M. and Niewold, T.A. 1995. Influence of physical stress on the plasma concentration of serum amyloid‐A (SAA) and haptoglobin (Hp) in calves. Vet. Quart. 17 (1): 9-12.
Ceciliani, F., Ceron, J.J., Eckersall, P.D. and Sauerwein, H. 2012. Acute phase proteins in ruminants. J. Proteomic. 75: 4207-4231.
Cray C., Zaias, J. and Altman, N.H. 2009. Acute phase response in animals: A review. Comp. Med. 59 (6): 517-526.
Danscher, A.M., Thoefner, M.B., Heegaard, P.M.H. , Ekstrøm, C.T. and Jacobsen, S. 2011. Acute phase protein response during acute ruminal acidosis in cattle. Livest. Sci. 135 (1): 62-69.
Eckersall, P.D. and Bell, R.. 2010. Acute phase proteins: biomarkers of infection and inflammation in veterinary medicine. Vet. J. 185 (1): 23-27.
Gruys, E., Toussaint, M.J., Niewold, T.A. and Koopmans, S.J. 2005. Acute phase reaction and acute phase proteins. J. Zhejiang Univ. Sci. 6 (11): 1045-1056.
Gruys, E., Toussaint, M.J., Niewold, T.A., Koopmans, S.J., van Dijk, E. and Meloen, R.H. 2006. Monitoring health by values of acute phase proteins. Acta Histochemica. 108 (3): 229-232.
Glass, E.J., Craigmile, S.C., Springbett, A., Preston, P.M., Kirvar, E., Wilkie, G.M., Eckersall, P.D., Hall, F.R. and Brown, C.G.D. 2003. The protozoan parasite, Theileria annulata, induces a distinct acute phase protein response in cattle that is associated with pathology. Int. J. Parasitol. 33: 1409-1418.
Heegaaed, P.M.H., Godson, D.L., Toussaint, M.J.M, Tjornehoj, K., Larsen, L.E., Viuff, B. and Ronsholt, L.. 2000. The acute phase response of haptoglobin and serum amyloid A (SAA) in cattle undergoing experimental infection with bovine respiratory sycytial virus. Vet. Immunol. Immunop. 77: 151-159.
Makimura, S. and Suzuki, N. 1982. Quantitative determination of bovine serum haptoglobin and its elevation in some inflammatory diseases. Nihon Juigaku Zasshi. 44: 15–21.
Murata, H., Shimada, N. and Yoshioka, M.. 2004. Current research on acute phase proteins in veterinary diagnosis: An overview. Vet. J. 168 (1): 28-40.
Nazifi, S., Razavi, S.M., Kaviani, F. and Rakhshandehroo, E.. 2012. Acute phase response in cattle infected with Anaplasmamarginale. Vet. Microbiol. 155: 267-271.
Petersen, H.H., Nielsen, J.P. and Heegaard, P.M. 2004. Application of acute phase protein measurements in veterinary clinical chemistry. Vet .Res. 35 (2): 163-187.