Osteosarcoma in the Mammary Gland of 17 dogs: Treatment, Clinical Prognostic Factor and Outcome

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Published: Jul 8, 2019
Keywords:
Osteosarcoma Mammary gland Dogs Treatment

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Siripattra Netramai Detkalaya
Lalita Suwantana
Sunee Kunakornsawat

Abstract

Seventeen dogs with mammary osteosarcomas were examined at Veterinary Teaching Hospital, Kasetsart University. Data collected in this study include patient characteristics, chemotherapy administration and life status. The results showed prognostic factors that significantly affected survival rates were size of tumor and postoperative chemotherapy administration (P<0.05). Dogs with tumor diameter greater than 3.5 cm. the risk of death increased by 3.86 times compared to dogs with a tumor diameter of less than 3.5 cm. Survival time of dogs receiving adjuvant chemotherapy compared with dogs did not have chemotherapy after surgery increased by 77%. The results suggested that the use of postoperative chemotherapy and surgical removal of the tumor at a small size can significantly increases the survival time.

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Detkalaya, S. N., Suwantana, L. and Kunakornsawat, S. (2019) “Osteosarcoma in the Mammary Gland of 17 dogs: Treatment, Clinical Prognostic Factor and Outcome”, Journal of Mahanakorn Veterinary Medicine, 14(1), pp. 47–55. Available at: https://li01.tci-thaijo.org/index.php/jmvm/article/view/159180 (Accessed: 24 November 2024).
Issue
Vol. 14 No. 1 (2019): January - June
Section
Research Article

References

Berg, J., M. J. Weinstein, D. S. Springfield, and W. M. Rand. 1995. Results of surgery and doxorubicin chemotherapy in dogs with osteosarcoma. J. AM. Anim. Hosp. Assoc. 206(10): 1555-1560.
Bergman. P. J., E. G. MacEwen, I. D. Kurzman, C. J. Henry, A. S. Hammer, D. W. Knapp, A. Hale, S. A. Kruth, M. K. Klein, J. Klausner, A. M. Norris, D. McCaw, R. C. Straw, and S. J. Withrow. 1996. Amputation and Carboplatin for Treatment of Dogs with Osteosarcoma: 48 Cases (1991 to 1993). J. Vet. Intern. Med. 10(2): 76-81.
Dannis, B., E. Hollis, W. Laurel, R. David, and H. Marlene. 2003. Carboplatin and Doxorubicin Combination Chemotherapy for the Treatment of Appendicular Osteosarcoma in the Dog. J. Vet. Intern. Med. 17: 199-205.
Eva, H. 2014. Canine Mammary Osteosarcomas. J. Veterinar. Sci. Technolo. 5: 2
Karin, S. 2003. Canine mammary gland tumors. Vet. Clin. Small Anim. 33: 573-596.
Kuntz, C. A., W. S. Dernell, B. E. Powers, and S. Withrow. 1998. Extraskeletal osteosarcomas in dogs: 14 cases. J. Am. Anim. Hosp. Assoc. 34(1): 26-30.
Langenbach, A., M. A. Anderson, D. M. Dambach, K. U. Sorenmo, and F. D. Shofer. 1998. Extraskeletal osteosarcomas in dogs: a retrospective study of 169 cases (1986-1996). J. Am. Anim. Hosp. Assoc. 34(2): 113-120.
Michael, S. K., S. Adam, A. L. Cheryl, and S. Bernard. 2004. Alternating Carboplatin and Doxorubicin as Adjunctive Chemotherapy to Amputation or Limb-Sparing Surgery in the Treatment of Appendicular Osteosarcoma in Dogs. J. Vet. Intern. Med. 18: 540-544.
Novosad, C. A. 2003. Principles of Treatment for Mammary Gland Tumors. Clin. Tech. Small Anim. Pract. 18(2): 107-109.
Patnaik, A. K. 1990. Canine Extraskeletal Osteosarcoma and Chondrosarcoma: a Clinicopathologic Study of 14 Cases. Vet. Pathol. 27: 46-55
Selmic, L. E., J. H. Burton, D. H. Thamm, S. J. Withrow, and S. E. Lana. 2014. Comparison of carboplatin and doxorubicin-based chemotherapy protocol in 470 dogs after amputation for treatment of Appendicular Osteosarcoma. J. Vet. Intern. Med. 28: 554-563.
Sleeckx, N, H. de Rooster, E. J. Veldhuis Kroeze, C. Van Ginneken, and L. Van Brantegem. 2011. Review article canine mammary tumors, an overview. Reprod. Dom. Anim. 46(6): 1112-1131.