22 bp INDEL Mutation Polymorphism of dopamine receptor D2 (DRD2) Gene of Thai Native Chicken in Narathiwat Province

Main Article Content

Hafis Datumada
Thanaset Thongsaiklaing

Abstract

DRD2 is a protein receptor that play a role in physiological variety of organisms. In poultry, DRD2 transmits the signals from dopamine neurotransmitters to regulate the reproductive system and maternal behaviors such as broodiness and maternal care. The objective of this study in order to identify the polymorphism of the 22 bp INDEL mutation in 5' flanking region of the DRD2 gene of Thai native chicken female in Narathiwat province. The results show DRD2 gene consists of 3 genotypes II, ID and DD with genotype frequency 0.029, 0.40 and 0.568 respectively. The allele frequency of allele I and D were 0.23 and 0.77 respectively.

Article Details

Section
Research Article

References

Al Kahtane, A., Y. Chaiseha, and M. El Halawani. 2003. Dopaminergic regulation of avian prolactin gene transcription. J. Mol. Endocrinol. 31: 185-196.

Bagheri Sarvestani, A. S., A. Niazi, M. J. Zamiri, and M. Dadpasand Taromsari. 2013. Polymorphisms of prolactin gene in a native chicken population and its association with egg production. Iranian J. Vet. Res. 14(2): 113-119.

Chaiseha, Y., O. Youngren, K. Al Zailaie, and M. El Halawani. 2003. Expression of D1 and D2 dopamine receptors in the hypothalamus and pituitary during the turkey reproductive cycle: colocalization with vasoactive intestinal peptide. Neuroendocrinology 77: 105–118.

Cui, J. X., H. L. Du, Y. Liang, X. M. Deng, N. Li and X. Q. Zhang. 2006. Association of Polymorphisms in the promoter region of chicken prolactin with egg production. Poult. Sci. 85: 26–31.

Fryxell K. J. 1995. The evolutionary divergence of neurotransmitter receptors and second-messenger pathways. J. Mol. Evol. 41: 85-97.

Falconer D. S. and T. F. C. Mackay. 1996. An introduction to quantitative genetics. 4th ed. Benjamin-Cummings. Longman, Oxford.

Goodwin, W., A. Linacre and S. Hadi. 2007. An Introduction to forensic genetics, 2nd ed. John Wiley & Sons Ltd. West Sussex, UK.

Komiyama, T., H. Iwama, N. Osada, Y. Nakamura, H. Kobayashi, Y. Tateno and T. Gojobori. 2014. Dopamine receptor genes and evolutionary differentiation in the domestication of fighting cocks and long-crowing chickens. PLOS one 9(7): 1-9.

Li, Z., M. Zheng, B. A. Abdalla, Z. Zhang, Z. Xu, Q. Ye, H. Xu, W. Luo, Q. Nie and X. Zhang. 2016. Genome-wide association study of aggressive behaviour in chicken. Sci. Rep. 6: 30981.

Mijanur Rahman, M.D., R. Matsuda, T. Matsuda, Y. Nishiyama, K. Jozaki, K. Anann and Y. Wada. 2014. Relationship between the production traits and three candidate genes in the prolactin’s In/Del × In/Del population of silkie fowl. J. Poult. Sci. 51: 138-143.

Mitrofanova, O. V., N. V. Dementeva, A. A. Krutikova, O. P. Yurchenko, A. B. Vakhrameev and V. P. Terletskiy. 2017. Association of polymorphic variants in MSTN, PRL, and DRD2 genes with intensity of young animal growth in Pushkin breed chickens. Cytol. Genet. 51(3): 179-184.

Robertsoi, D., I. Biaggioni, G. Burustock, P. A. Low and J. F. R. Paton. 2012. Primer on the autonomic nervous system. Elsevier Inc. San Diego, USA.

Sartsoongnoen N, S. Kosonsiriluk, N. Prakobsaeng, T. Songserm I. Rozenboim, M. E. Halawan and Y. Chaischa. 2008. The dopaminergic system in the brain of the native Thai chicken, Gullus domesticus: localization and differential expression across the reproductive cycle. Gen. Comp. Endocrinol. 159: 107-115.

Schnell, S. A., S. You, D. N. Foster and M. E. El Halawani. 1999. Molecular cloning and tissue distribution of an avian D2 dopamine receptor mRNA from the domestic turkey (Meleagris gallopavo). J. Comp. Neurol. 407: 543–554.

Xu, H. P., X. Shen, M. Zhou, C. L. Luo, L. Kang, Y. Linng, I. L. Zeng, Q. H. Nie, D. X. Zhang and X. Q. Zhang. 2009. The dopamine D2 receptor gene polymorphisms associated with chicken broodiness. Poult. Sci. 89: 428-438.

Xu, H. P., H. Zeng, D. X. Zhang, X. L. Jia, C. L. Luo, M. X. Fang, Q. H. Nie and X. Q. Zhang. 2011. Polymorphisms associated with egg number at 300 days of age in chickens. Genet. Mol. Res. 10(4): 2279-2289.

Ye, Q., J. Xu, X. Gao, H. Ouyang, W. Luo and Q. Nie. 2017. Associations of IGF2 and DRD2 polymorphisms with laying traits in Muscovy duck. Peer J. 5: e4083.

Youngren, O. M., G. R. Pitts, R. E. Phillips and M. E. El Halawani. 1996. Dopaminergic control of prolactin secretion in the turkey. Gen. Comp. Endocrinol. 104: 225-230.