Analysis of Bovine T Lymphocyte Subpopulation in Asymptomatic Cross Breed Cattle

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Teerawin Bouma
Jirakrit Saetang
Surasak Sangkhathat


Bovine theileriosis is caused by Theileria spp. that infect white blood cells (WBCs) and red blood cells (RBCs). Native cattle infected with Theileria spp. does not show clearly clinical signs that may be associated with the function of immune cells. CD4+ cells are required to activate the function of CD8+ cells that involve the elimination of the infected cells. As a result, the function of immune response can contribute those abnormal clinical signs. Tregs are responsible for inhibiting the function of immune cells such as CD4+ cells and CD8+ cells etc. The function of Tregs in cattle with Theileriosis has not been clearly explored. This study is to investigate the proportion of CD4+ cells, CD8+ cells and Tregs in symptomatic cattle infected with Theileria spp. Crossbred Native and Brahman cattle with healthy clinical signs were chosen to collect blood for hematology, biochemistry profiles and the proportion of lymphocytes. The results showed that the cattle infected with Theileria spp. has the blood test results, hematology, biochemical profiles, within the normal range. The proportion of CD4+ cells and CD8+ cells tend to be lower slightly, whereas the proportion of Tregs is not affected comparing with the proportion of lymphocytes in uninfected cattle from previous reports. Then, the reduction of CD4+ cells and CD8+ cells might be affected by other pathway of immune response that does not involve the function of Tregs.


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