Analysis of Bovine T Lymphocyte Subpopulation in Asymptomatic Cross Breed Cattle
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Abstract
Bovine theileriosis is caused by Theileria spp. that infect white blood cells (WBCs) and red blood cells (RBCs). Native cattle infected with Theileria spp. does not show clearly clinical signs that may be associated with the function of immune cells. CD4+ cells are required to activate the function of CD8+ cells that involve the elimination of the infected cells. As a result, the function of immune response can contribute those abnormal clinical signs. Tregs are responsible for inhibiting the function of immune cells such as CD4+ cells and CD8+ cells etc. The function of Tregs in cattle with Theileriosis has not been clearly explored. This study is to investigate the proportion of CD4+ cells, CD8+ cells and Tregs in symptomatic cattle infected with Theileria spp. Crossbred Native and Brahman cattle with healthy clinical signs were chosen to collect blood for hematology, biochemistry profiles and the proportion of lymphocytes. The results showed that the cattle infected with Theileria spp. has the blood test results, hematology, biochemical profiles, within the normal range. The proportion of CD4+ cells and CD8+ cells tend to be lower slightly, whereas the proportion of Tregs is not affected comparing with the proportion of lymphocytes in uninfected cattle from previous reports. Then, the reduction of CD4+ cells and CD8+ cells might be affected by other pathway of immune response that does not involve the function of Tregs.
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References
Abbott, J. R. et al. 2005. Rapid and Long-Term Disappearance of CD4+ T Lymphocyte Responses Specific for Anaplasma Marginale Major Surface Protein-2 (MSP2) in MSP2 Vaccinates following Challenge with Live A. marginale1. The Journal of Immunology 174: 6702-6715.
Agina, O. et al. 2020. Clinical Pathology, Immunopathology and Advanced Vaccine Technology in Bovine Theileriosis: A Review.
Agina, O. A. et al. 2021. Molecular detection of Theileria species, Anaplasma species, Candidatus Mycoplasma haemobos, Trypanosoma evansi and first evidence of Theileria sinensis-associated bovine anaemia in crossbred Kedah-Kelantan x Brahman cattle. BMC Veterinary Research 17: 246.
Ahmed, J. 2002. The role of cytokines in immunity and immunopathogenesis of pirolasmoses. Parasitology Research 88: S48-S50.
Ahmed, J. S., E. J. Glass, D. A. Salih, and U. Seitzer. 2008. Review: Innate immunity to tropical theileriosis. Innate Immunity 14: 5-12.
Almazán, C., R. C. Scimeca, M. V. Reichard, and J. Mosqueda. 2022. Babesiosis and Theileriosis in North America. Pathogens 11 Accessed Date Accessed.| doi:DOI|
Altangerel, K. et al. 2011. MOLECULAR PREVALENCE OF DIFFERENT GENOTYPES OF THEILERIA ORIENTALIS DETECTED FROM CATTLE AND WATER BUFFALOES IN THAILAND. The Journal of Parasitology 97: 1075-1079.
Ayadi, O., M. Gharbi, and M. Benchikh-Elfegoun. 2016. Haematological and biochemical indicators of tropical theileriosis diseased cattle in wilaya of Sétif (North East Algeria). Journal of parasitic diseases 41.
Aziz, N., M. Maksudi, and Y. Prakoso. 2019. Correlation between hematological profile and theileriosis in Bali cattle from Muara Bulian, Jambi, Indonesia. Veterinary World 12: 1358-1361.
Calder, P. C. 2013. Feeding the immune system. Proceedings of the Nutrition Society 72: 299-309.
Ingvartsen, K. L., and K. Moyes. 2013. Nutrition, immune function and health of dairy cattle. Animal 7: 112-122.
Kim, Y.-M. et al. 2016. Reference ranges of hematology and lymphocyte subsets in healthy Korean native cattle (Hanwoo) and Holstein dairy cattle. Animal Science Journal 87: 796-801.
Preston, P. M. et al. A dual role for immunosuppressor mechanisms in infection with Theileria annulata: well-regulated suppressor macrophages help in recovery from infection; profound immunosuppression promotes non-healing disease.
Rakwong, P., N. Keawchana, R. Ngasaman, and K. Kamyingkird. 2022. Theileria infection in bullfighting cattle in Thailand.
Rauf, U. et al. 2020. Humoral and Cell-Mediated Immune Response Validation in Calves after a Live Attenuated Vaccine of Babesia bigemina. Pathogens 9: 936.
Sajiki, Y. et al. 2020. The Suppression of Th1 Response by Inducing TGF-β1 From Regulatory T Cells in Bovine Mycoplasmosis. Frontiers in Veterinary Science 7: 1031.
Torina, A. et al. 2020. Immune Response to Tick-Borne Hemoparasites: Host Adaptive Immune Response Mechanisms as Potential Targets for Therapies and Vaccines. International Journal of Molecular Sciences 21: 8813.
Veiga-Parga, T. 2016. Regulatory T Cells and Their Role in Animal Disease. Veterinary Pathology 53: 737-745.
Velavan, T. P., and O. Ojurongbe. 2011. Regulatory T cells and parasites.
Yang, J., A. Pemberton, W. I. Morrison, and T. Connelley. 2018. Granzyme B Is an Essential Mediator in CD8+ T Cell Killing of Theileria parva-Infected Cells. Infection and Immunity 87: e00386-00318.