Comparison of neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR) and platelet-to-lymphocyte ratio (PLR) between dogs with chronic renal failure and clinically normal dogs
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Abstract
Chronic renal failure (CRF) is a common disease in elderly dogs. This condition significantly impacts their quality of life and increases mortality rates. There are many causes of this disease. Inflammation plays a crucial role in CRF, affecting up to 30% of cases. Elevating white blood cell and platelet counts are associated with inflammatory process. The objectives of this study were to compare neutrophil-to-lymphocyte (NLR) ratio, monocyte-to-lymphocyte (MLR) ratio, and platelet-to-lymphocyte ratio (PLR) between dogs with CRF and clinically normal dogs. Data were collected and analyzed from 55 dogs with CRF and 57 clinically normal dogs. The study found statistically significant differences (P<0.05) that dogs with CRF had the values of NLR = 8.33±7.48, MLR = 0.64±0.64 and PLR = 2.98±2.95 higher than clinically normal dogs that had the values of NLR = 3.79±2.25, MLR = 0.26±0.16 และ PLR = 1.71±0.80. The receiver operating characteristic (ROC) curve showed that the areas under curve (AUC) of NLR, MLR, and PLR were 0.70, 0.72, and 0.60, respectively. From all studied data, it was found that the MLR values were significantly different. Using these MLR values to help monitor and evaluate the chronic renal failure in the future should be further studied.
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References
Alves, F., Prata, S., Nunes, T., Gomes, J., Aguiar, S., Aires da Silva, F., Tavares, L., Almeida, V. and Gil, S. 2020. Canine parvovirus: a predicting canine model for sepsis. BMC Vet. Res. 16(1): 199.
Bennett F. 2004. Unilateral renal cell carcinoma in a Labrador retriever. Can Vet J, 45(10), 860–862.
Benvenuti, E., Pierini, A., Gori, E., Lucarelli, C., Lubas, G. and Marchetti, V. 2020. Neutrophil-to-Lymphocyte ratio (NLR) in canine inflammatory bowel disease (IBD). Vet. Sci. 7(3): 141.
Chikazawa, S. and Dunning, M. D. 2016. A review of anaemia of inflammatory disease in dogs and cats. J. Small Anim. Pract. 57(7): 348–353.
Coyne, M., Szlosek, D., Clements, C., McCrann, D. and Olavessen, L. 2020. Association between breed and renal biomarkers of glomerular filtration rate in dogs. Vet. Rec. 187(10): e82.
De Santis, F., Boari, A., Dondi, F. and Crisi, P. E. 2022. Drug-Dosing adjustment in dogs and cats with chronic kidney disease. Animals. 12(3): 262.
Dunaevich, A., Chen, H., Musseri, D., Kuzi, S., Mazaki-Tovi, M., Aroch, I. and Segev, G. 2020. Acute on chronic kidney disease in dogs: Etiology, clinical and clinicopathologic findings, prognostic markers, and survival. J. Vet. Intern. Med. 34(6): 2507–2515.
Ephraim, E., Cochrane, C. Y., and Jewell, D. E. 2020. Varying protein levels influence metabolomics and the gut microbiome in healthy adult dogs. Toxins. 12(8): 517.
Espinoza, V. E. and Emmady, P. D. 2023. Histology, Monocytes. In StatPearls. StatPearls Publishing.
Guo, R., Duan, J., Pan, S., Cheng, F., Qiao, Y., Feng, Q., Liu, D. and Liu, Z. 2023. The Road from AKI to CKD: Molecular mechanisms and therapeutic targets of ferroptosis. Cell Death dis. 14(7): 426.
Hua, Y., Sun, J. Y., Lou, Y. X., Sun, W. and Kong, X. Q. 2023. Monocyte-to-lymphocyte ratio predicts mortality and cardiovascular mortality in the general population. Int. J. Cardiol. 379: 118–126.
International Renal Interest Society (IRIS).2023. IRIS staging of CKD (modified 2023). Accessed May 25, 2024. http://www.iris-kidney.com/pdf/2_IRIS_Staging_of_CKD_2023.pdf
Kim, Y. M., Polzin, D. J., Rendahl, A.and Granick, J. L. 2019. Urinary neutrophil gelatinase-associated lipocalin in dogs with stable or progressive kidney disease. J. Vet. Intern. Med. 33(2): 654–661.
Kwon, Y. J., Suh, G. H., Kang, S. S.and Kim, H. J. 2018. Successful management of proteinuria and systemic hypertension in a dog with renal cell carcinoma with surgery, telmisartan, and amlodipine. Can. Vet. J. 59(7): 759–762.
Lin, L. and Hu, K. 2023. Macrophage function modulated by tPA signaling in mouse experimental kidney disease models. Int. J. Mol. Sci. 24(13): 11067.
Lippi, I., Perondi, F., Meucci, V., Bruno, B., Gazzano, V. and Guidi, G. 2018. Clinical utility of urine kidney injury molecule-1 (KIM-1) and gamma-glutamyl transferase (GGT) in the diagnosis of canine acute kidney injury. Vet. Res. Commun. 42(2): 95–100.
Liu, X., Zhang, Q., Wu, H., Du, H., Liu, L., Shi, H., Wang, C., Xia, Y., Guo, X., Li, C., Bao, X., Su, Q., Sun, S., Wang, X., Zhou, M., Jia, Q., Zhao, H., Song, K. and Niu, K. 2015. Blood Neutrophil to Lymphocyte ratio as a predictor of hypertension. Am. J. Hypertens. 28(11): 1339–1346.
Maeda, A., Hayase, N. and Doi, K. 2020. Acute kidney injury induces innate immune response and neutrophil activation in the lung. Front. Med. 7: 565010.
Martello, E., Perondi, F., Capucchio, M. T., Biasato, I., Biasibetti, E., Cocca, T., Bruni, N. and Lippi, I. 2020. Efficacy of a new dietary supplement in dogs with advanced chronic kidney disease. PeerJ.8: e9663.
McKenzie, B. A., Chen, F. L., Gruen, M. E. and Olby, N. J. 2022. Canine geriatric syndrome: A framework for advancing research in veterinary geroscience. Front. Vet. Sci. 9: 853743.
Miyagawa, Y., Akabane, R., Ogawa, M., Nagakawa, M., Miyakawa, H. and Takemura, N. 2020. Serum cystatin C concentration can be used to evaluate glomerular filtration rate in small dogs. J. Vet. Med. Sci. 82(12): 1828–1834.
Miyakawa, H., Hsu, H. H., Ogawa, M., Akabane, R., Miyagawa, Y. and Takemura, N. 2021. Association between serum fibroblast growth factor-23 concentration and development of hyperphosphatemia in normophosphatemic dogs with chronic kidney disease. J. Vet. Intern. Med. 35(5):1 2296–2305.
Mureșan, A. V., Russu, E., Arbănași, E. M., Kaller, R., Hosu, I., Arbănași, E. M. and Voidăzan, S. T. 2022. The predictive value of NLR, MLR, and PLR in the outcome of end-stage kidney disease patients. Biomedicines 10(6): 1272.
Nabi, S.U., Wani, A.R., Shah, O. and Dey, S. 2014. Association of periodontitis and chronic kidney disease in dogs. Vet. World. 7: 403-407.
Niculae, A., Gherghina, M. E., Peride, I., Tiglis, M., Nechita, A. M. and Checherita, I. A. 2023. Pathway from acute kidney injury to chronic kidney disease: Molecules involved in renal fibrosis. Int. J. Mol. Sci.24(18): 14019.
Nivy, R., Chaim, N., Hanael, E., Sutton, G. A., Bruchim, Y., Aroch, I. and Segev, G. 2021. Prospective evaluation of 5 urinary biomarkers as predictors of acute kidney injury in nonazotemic, hospitalized dogs. J. Vet. Intern. Med. 35(6): 2812–2820.
Neuen, B. L., Chadban, S. J., Demaio, A. R., Johnson, D. W. and Perkovic, V. 2017. Chronic kidney disease and the global NCDs agenda. BMJ glob. health. 2(2): e000380.
Oburai, N. L., Rao, V. V. and Bonath, R. B. 2015. Comparative clinical evaluation of Boerhavia diffusa root extract with standard Enalapril treatment in Canine chronic renal failure. J. Ayurveda Integr. Med. 6(3): 150–157.
Picelli de Azevedo, M. G., Salgueiro Geraldes, S., Bilbau Sant'Anna, P., Poloni Batista, B., Rodrigues Maia, S., Silveira de Moraes, R., Moreira Dos Santos Schmidt, E., Ferreira de Souza, F., Melchert, A., Pinheiro Ferreira, J. C., Rezende Dadalto, C., Mogollón García, H. D. and Chalfun Guimarães-Okamoto, P. T. 2022. C-reactive protein concentrations are higher in dogs with stage IV chronic kidney disease treated with intermittent hemodialysis. PloS One 17(9): e0274510.
Ramezani, A. and Raj, D. S. 2014. The gut microbiome, kidney disease, and targeted interventions. J. Am. Soc. Nephrol. 25(4): 657–670.
Tvedten, H. and Raskin, R. E. 2012. Leukocyte Disorders. In: Willard, M.D. and Tvedten, H. (eds.): Small Animal Clinical Diagnosis by Laboratory Methods. 5th Saunders. P. 63–91.
Uduagbamen, P. , Oyelese, A. , AdebolaYusuf, A. , Thompson, M. , Alalade, B. and Ehioghae, O. 2022. Neutrophil Lymphocyte ratio as an inflammatory marker in chronic kidney disease: Determinants and Correlates. Open J. Nephrol. 12: 23-35.
Yilmaz, M. I., Carrero, J. J., Axelsson, J., Lindholm, B. and Stenvinkel, P. 2007. Low-grade inflammation in chronic kidney disease patients before the start of renal replacement therapy: sources and consequences. Clin. Nephrol. 68(1): 1–9.