In silico Prediction of the Interaction between Phytochemicals in Local Plants and Crucial Proteins of Helicobacter pylori
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Abstract
Helicobacter pylori is a bacterium responsible for several diseases from infection in the stomach to stomach cancer. The treatment for the infection is to use antibiotics, but some antibiotic-resistant strains are found. Therefore, the information of compounds for the new antibiotic candidates against those bacterial strains is crucial. The current study aimed to screen the plausible candidates from phytochemicals found in local plants that could bind to H. pylori proteins: GyrA and PBP2 This was implemented by using protein–ligand docking technique. The results showed that out of 24 phytochemicals tested, quercetin and panduratin A were the topmost favorable ligands. Thus, these ligands have potential for drug development.
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