Synthesis, Characterization, Photo-Physical Properties, Quenching Reaction and Anticancer Activity Against Cancer Cell Lines of Ir(III) Complex Containing PPh3 Ligand

Authors

  • Rattanyu Kongpan Division of Physical Science and Center of Excellence for Innovation in Chemistry, Faculty of Science, Prince of Songkla University,
  • Saowanit Saithong Division of Physical Science (Chemistry), Faculty of Science, PSU
  • Juangjan Wuttipan Division of Physical Science and Center of Excellence for Innovation in Chemistry, Faculty of Science, Prince of Songkla University,
  • Avirut Chinkulkijniwat Center of Excellence in Civil Engineering, School of Civil Engineering, Suranaree University of Technology,
  • Nararak Leesakul Division of Physical Science and Center of Excellence for Innovation in Chemistry, Faculty of Science, Prince of Songkla University,

Keywords:

iridium (III) complex, triphenylphosphine, luminescence activity, anticancer

Abstract

In this study, [Ir(ppy)2(PPh3)Cl].CH2Cl2.H2O complex was synthesized via the substitution reaction between Ir(III) dimeric complex with triphenylphosphine (PPh3) ligand in dichloromethane solvent. The complex was characterized by single crystal X-ray diffraction, 1H-NMR, FTIR spectroscopies and elemental analysis. Photo-physical properties of the title complex were studied for a further application based on its luminescence at 489 nm with an excitation wavelength at 350 nm. It behaved as a turn-off luminescent chemosensor toward Fe(III) ion concentrations. In addition, it was investigated for anti-breast cancer activity against four cell lines of MCF-7, MDA-MB-231, MDA-MB-468 and BT-549 with IC50 values: 7.03±0.99, 5.85±0.36, 6.10±0.14 and 6.20±0.07 mM, respectively.

Author Biographies

Rattanyu Kongpan, Division of Physical Science and Center of Excellence for Innovation in Chemistry, Faculty of Science, Prince of Songkla University,

Hat Yai, Songkhla 90110, Thailand.

Saowanit Saithong, Division of Physical Science (Chemistry), Faculty of Science, PSU

Division of Physical Science and Center of Excellence for Innovation in Chemistry, Faculty of Science, Prince of Songkla University,

Juangjan Wuttipan, Division of Physical Science and Center of Excellence for Innovation in Chemistry, Faculty of Science, Prince of Songkla University,

Hat Yai, Songkhla 90110, Thailand.

Avirut Chinkulkijniwat, Center of Excellence in Civil Engineering, School of Civil Engineering, Suranaree University of Technology,

Muang, Nakhon Ratchasima 30000, Thailand.

Nararak Leesakul, Division of Physical Science and Center of Excellence for Innovation in Chemistry, Faculty of Science, Prince of Songkla University,

Hat Yai, Songkhla 90110, Thailand.

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Published

2023-08-31

How to Cite

Kongpan, R., Saithong, S., Wuttipan, J., Chinkulkijniwat, A., & Leesakul, N. (2023). Synthesis, Characterization, Photo-Physical Properties, Quenching Reaction and Anticancer Activity Against Cancer Cell Lines of Ir(III) Complex Containing PPh3 Ligand. Recent Science and Technology, 15(2), 537–551. Retrieved from https://li01.tci-thaijo.org/index.php/rmutsvrj/article/view/254662

Issue

Vol. 15 No. 2 (2023): ๋May- August 2023

Section

Research Article

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