Synthesis, Characterization, Photo-Physical Properties, Quenching Reaction and Anticancer Activity Against Cancer Cell Lines of Ir(III) Complex Containing PPh3 Ligand
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Abstract
In this study, [Ir(ppy)2(PPh3)Cl].CH2Cl2.H2O complex was synthesized via the substitution reaction between Ir(III) dimeric complex with triphenylphosphine (PPh3) ligand in dichloromethane solvent. The complex was characterized by single crystal X-ray diffraction, 1H-NMR, FTIR spectroscopies and elemental analysis. Photo-physical properties of the title complex were studied for a further application based on its luminescence at 489 nm with an excitation wavelength at 350 nm. It behaved as a turn-off luminescent chemosensor toward Fe(III) ion concentrations. In addition, it was investigated for anti-breast cancer activity against four cell lines of MCF-7, MDA-MB-231, MDA-MB-468 and BT-549 with IC50 values: 7.03±0.99, 5.85±0.36, 6.10±0.14 and 6.20±0.07 mM, respectively.
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