Advancements in the Treatment of Early-Stage Hemorrhoids
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Abstract
Hemorrhoids are a prevalent condition affecting a significant portion of the global population. While early-stage hemorrhoids can be managed with relative ease, surgery may be necessary in certain cases. The advancement of early-stage hemorrhoid treatment has experienced substantial success in the past, particularly with the introduction of minimally invasive treatment methods and other innovative medical therapies. The aim of this review is to examine the progress made in both conventional and novel treatment approaches for hemorrhoids, and to propose potential avenues for future treatment development. Additionally, this review will highlight examples of new drug research and development techniques that hold promise for improving outcomes among patients with this condition.
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References
Lawrence A, McLaren ER. External Hemorrhoid [Internet]. Treasure Island (FL): StatPearls; 2022. [Cited 2022 Aug 8]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK500009/
Fontem RF, Eyvazzadeh D. Internal Hemorrhoid [Internet]. Treasure Island (FL): StatPearls; 2022. [Cited 2022 Aug 1]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK537182/
De Marco S, Tiso D. Lifestyle and risk factors in hemorrhoidal disease. Front Surg. 2021;8:729166.
Lohsiriwat V. Hemorrhoids: from basic pathophysiology to clinical management. World J Gastroenterol. 2012;18:2009-2017.
Mott T, Latimer K, Edwards C. Hemorrhoids: diagnosis and treatment options. Am Fam Physician. 2018;97:172-179.
Perrotti P, Antropoli C, Molino D, De Stefano G, Antropoli M. Conservative treatment of acute thrombosed external hemorrhoids with topical nifedipine. Dis Colon Rectum. 2001;44:405-409.
Picciariello A, Rinaldi M, Grossi U, Verre L, De Fazio M, Dezi A, et al. Management and Treatment of External Hemorrhoidal Thrombosis. Front Surg. 2022;9:898850.
Tarasconi A, Perrone G, Davies J, Coimbra R, Moore E, Azzaroli F, et al. Anorectal emergencies: WSES-AAST guidelines. World J Emerg Surg. 2021;16:48.
Giannini I, Amato A, Basso L, Tricomi N, Marranci M, Pecorella G, et al. Flavonoids mixture (diosmin, troxerutin, hesperidin) in the treatment of acute hemorrhoidal disease: a prospective, randomized, triple-blind, controlled trial. Tech Coloproctol. 2015;19: 339-345.
Corsale I, Carrieri P, Martellucci J, Piccolomini A, Verre L, Rigutini M, et al. Flavonoid mixture (diosmin, troxerutin, rutin, hesperidin, quercetin) in the treatment of I-III degree hemorroidal disease: a double-blind multicenter prospective comparative study. Int J Colorectal Dis. 2018;33:1595-1600.
Orefice R, Litta F, Parello A, De Simone V, Campennì P, Marra AA, et al. A prospective study on the efficacy of two different phlebotonic therapies as a bridge to surgery in patients with advanced hemorrhoidal disease. J Clin Med. 2021;10:1549.
National Drug Information of Food and Drug Administration Thailand [Internet]. Ndi.fda.moph.go.th; 2023. [cited 2023 Mar 18]. Available from: http://ndi.fda.moph.go.th/ndi_faq
Perez-Miranda M, Gomez-Cedenilla A, León-Colombo T, Pajares J, Mate-Jimenez J. Effect of fiber supplements on internal bleeding hemorrhoids. Hepatogastroenterology. 1996;43:1504-1507.
Lohsiriwat V. Treatment of hemorrhoids: A coloproctologist's view. World J Gastroenterol. 2015;21:9245-9252.
Garg P, Singh P. Adequate dietary fiber supplement and TONE can help avoid surgery in most patients with advanced hemorrhoids. Minerva Gastroenterol Dietol. 2017;63:92-96.
Hollingshead JR, Phillips RK. Haemorrhoids: modern diagnosis and treatment. Postgrad Med J. 2016;92:4-8.
Alonso-Coello P, Guyatt G, Heels-Ansdell D, Johanson JF, Lopez-Yarto M, Mills E, et al. Laxatives for the treatment of hemorrhoids. Cochrane Database Syst Rev. 2005;2005: CD004649.
Yang J, Wang HP, Zhou L, Xu CF. Effect of dietary fiber on constipation: a meta analysis. World J Gastroenterol. 2012;18: 7378-7383.
Bashir A, Sizar O. Laxatives. [Internet]. Treasure Island (FL): StatPearls; 2022. [Cited 2022 Oct 13].Available from: https://www.ncbi.nlm.nih.gov/books/NBK537246/
Tan KY, Seow-Choen F. Fiber and colorectal diseases: separating fact from fiction. World J Gastroenterol. 2007;13:4161-4167.
Garg P, Singh P. Adequate dietary fiber supplement and TONE can help avoid surgery in most patients with advanced hemorrhoids. Minerva Gastroenterol Dietol. 2017;63:92-6.
Alonso-Coello P, Guyatt G, Heels-Ansdell D, Johanson JF, Lopez-Yarto M, Mills E, et al. Laxatives for the treatment of hemorrhoids. Cochrane Database Syst Rev. 2005;4: CD004649