The Anti-apoptosis Effect of Curcumin I on bax/bcl-2 Ratio Against 6-OHDA Induced SH-SH5Y Toxicity

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Keywords:
6-OHDA Curcumin I Bax Bcl-2 Phospho-P38

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Yamaratee Jaisin
Departmaent of Pharmacology, Faculty of Science, Mahidol University, Bangkok
Benjawan Meesarapee
Departmaent of Pharmacology, Faculty of Science, Mahidol University, Bangkok
Anusorn Thampithak
Departmaent of Pharmacology, Faculty of Science, Mahidol University, Bangkok
Piyanee Ratanachamnong
Departmaent of Pharmacology, Faculty of Science, Mahidol University, Bangkok
Laddawan Phivthong-ngam
Department of Pharmacology, Faculty of Medicine, Srinakharinwirot University, Bangkok
Apichart Suksamrarn
Department of Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkok
Sukumal Chongthammakun
Department of Anatomy, Faculty of Science, Mahidol University, Bangkok
Noppawan Phumala-Morales
Departmaent of Pharmacology, Faculty of Science, Mahidol University, Bangkok
Piyarat Govitrapong
Departmaent of Pharmacology, Faculty of Science, Mahidol University, Bangkok and Center for Neuroscience, Faculty of Science, Mahidol University, Bangkok
Sanvarinda Y
Departmaent of Pharmacology, Faculty of Science, Mahidol University, Bangkok and Center for Neuroscience, Faculty of Science, Mahidol University, Bangkok

Abstract

Curcumin is a naturally occurring polyphenolic compound. It has been reported that it
exerts anti-oxidative and anti-apoptotic activities. 6-Hydroxydopamine (6-OHDA) is used as
a neurotoxin to generate a model of Parkinson’s disease. In the present study, we investigate
whether curcumin I (diferuloylmethane) could protect SH-SY5Y, dopaminergic cells from 6-
OHDA-induced neurotoxicity. The results showed that pretreatment with curcumin I
significantly prevented 6-OHDA induced cell viability reduction. Further experiments
indicated that curcumin I could protect 6-OHDA-induced apoptosis signaling cascades
activation. The results showed that pretreatment with curcumin I could prevent 6-OHDAinduced
increasing of Bax/Bcl-2 ratio. This study suggested that curcumin I exerts its
protective effects against 6-OHDA induced neurotoxicity. Therefore, curcumin I may be used
as a potential compound for preventing oxidative stress-induced neurodegeneration.

Article Details

Issue
Vol. 32 No. 1 (2010): Thai Journal of Pharmacology
Section
2010 Annual Meeting Abstracts/Lectures

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