The Anti-apoptosis Effect of Curcumin I on bax/bcl-2 Ratio Against 6-OHDA Induced SH-SH5Y Toxicity

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Yamaratee Jaisin
Benjawan Meesarapee
Anusorn Thampithak
Piyanee Ratanachamnong
Laddawan Phivthong-ngam
Apichart Suksamrarn
Sukumal Chongthammakun
Noppawan Phumala-Morales
Piyarat Govitrapong
Sanvarinda Y


Curcumin is a naturally occurring polyphenolic compound. It has been reported that it
exerts anti-oxidative and anti-apoptotic activities. 6-Hydroxydopamine (6-OHDA) is used as
a neurotoxin to generate a model of Parkinson’s disease. In the present study, we investigate
whether curcumin I (diferuloylmethane) could protect SH-SY5Y, dopaminergic cells from 6-
OHDA-induced neurotoxicity. The results showed that pretreatment with curcumin I
significantly prevented 6-OHDA induced cell viability reduction. Further experiments
indicated that curcumin I could protect 6-OHDA-induced apoptosis signaling cascades
activation. The results showed that pretreatment with curcumin I could prevent 6-OHDAinduced
increasing of Bax/Bcl-2 ratio. This study suggested that curcumin I exerts its
protective effects against 6-OHDA induced neurotoxicity. Therefore, curcumin I may be used
as a potential compound for preventing oxidative stress-induced neurodegeneration.


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2010 Annual Meeting Abstracts/Lectures