Gastroprotective Effect of Thai Propolis

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Chaiyong Rujjanawate
Duangpom Amomlerdpison
Duangta Kanjanapothi


Propolis is a resinous substance collected by honeybees from plant exudates. The present study was undertaken to evaluate Thai propolis for its anti-gastric ulcer activity by experimental models. Oral administration of the propolis at 100 and 200 mg/kg significantly inhibited gastric ulcer formation induced by indomethacin, HCl/EtOH, and water immersion restraint-stress in rats. In pylorus ligated rats, pretreatment with propolis had no effect on gastric volume and pH thus indicating the lack of antisecretory effect of propolis. In ethanol-induced ulcerated rats, gastric wall mucus and hexosamine content  were markedly preserved by the propolis pretreatment. The findings indicated that Thai propolis possessed gastroprotective potential related to preservation of gastric mucus synthesis and secretion.


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