Main Article Content
Propolis is a resinous substance collected by honeybees from plant exudates. The present study was undertaken to evaluate Thai propolis for its anti-gastric ulcer activity by experimental models. Oral administration of the propolis at 100 and 200 mg/kg significantly inhibited gastric ulcer formation induced by indomethacin, HCl/EtOH, and water immersion restraint-stress in rats. In pylorus ligated rats, pretreatment with propolis had no effect on gastric volume and pH thus indicating the lack of antisecretory effect of propolis. In ethanol-induced ulcerated rats, gastric wall mucus and hexosamine content were markedly preserved by the propolis pretreatment. The findings indicated that Thai propolis possessed gastroprotective potential related to preservation of gastric mucus synthesis and secretion.
Upon acceptance of an article, the Pharmacological and Therapeutic Society of Thailand will have exclusive right to publish and distribute the article in all forms and media and grant rights to others. Authors have rights to use and share their own published articles.