Cancer Chemopreventive Potential of Indian Gooseberry (Phyllanthus emblica)
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Abstract
Indian gooseberry (Phyllanthus emblica) is enriched with different phytochemicals, such as tannins, flavonoids, alkaloids, triterpenes saponins, sterol, phenylpropanoids and phenol. These phytochemicals show cancer chemopreventive effects at various stages of carcinogenesis, including initiation, promotion, and progression via diverse mechanisms. During the initiation stage, the phytochemicals in Indian gooseberry can modulate Phase I and / or Phase II xenobiotic metabolizing enzyme activities. Furthermore, their active ingredients influence either cell proliferation or induction of cell apoptosis when initiated cells are transformed into benign tumors. The cancer chemopreventive agents in Indian gooseberry also inhibit matrix metalloproteinase (MMP) enzyme activities to prevent cancer cells spreading to other target organs. This article discusses cancer chemopreventive mechanisms of phytochemical compounds contained in Indian gooseberry at various stages of carcinogenesis. It is expected that Indian gooseberry will be one of the chemopreventive fruits used for further cancer prevention approaches.
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Mao X, Wu LF, Guo HL, et al. The Genus Phyllanthus: An Ethnopharmacological, Phytochemical, and Pharmacological Review. Evid Based Complement Alternat Med 2016; 2016: 7584952.
Hasan R, Islam N,Islam R. Phytochemistry, pharmacological activities and traditional uses of Emblica officinalis: A review. Int curr pharm j 2016; 5(2): 14-21.
Khan KH. Roles of Emblica officinalis in Medicine - A Review. Bot Res Int 2009; 2(4).
Singh E, Sharma S, Pareek A, et al. Phytochemistry, traditional uses and cancer chemopreventive activity of Amla (Phyllanthus emblica): The Sustainer. JAPS 2012; 2: 176-83.
Baliga MS,Dsouza JJ. Amla (Emblica officinalis Gaertn), a wonder berry in the treatment and prevention of cancer. Eur J Cancer Prev 2011; 20(3): 225-39.
Peterson CT, Denniston K,Chopra D. Therapeutic Uses of Triphala in Ayurvedic Medicine. J Altern Complement Med 2017; 23(8): 607-14.
กองยุทธศาสตร์และแผนงาน สำนักงานปลัด กระทรวงสาธารณสุข. สถิติสาธารณสุข พ.ศ.2562, 2562: 39-40.
Morse MA,Stoner GD. Cancer chemoprevention: principles and prospects. Carcinogenesis 1993; 14(9): 1737-46.
Oliveira PA, Colaco A, Chaves R, et al. Chemical carcinogenesis. An Acad Bras Cienc 2007; 79(4): 593-616.
Wattenberg LW. Chemoprevention of cancer. Cancer Res 1985; 45(1): 1-8.
Kumar A, Singh A, Singh B. Assessment of therapeutic potential of Phyllanthus emblica (Amla): A natural Godsend. IJCSB 2014; 3: 4-14.
Vazirian M, Khanavi M, Amanzadeh Y, et al. Quantification of gallic acid in fruits of three medicinal plants. Iran J Pharm Res 2011; 10(2): 233-6.
Yang B,Liu P. Composition and biological activities of hydrolyzable tannins of fruits of Phyllanthus emblica. J Agric Food Chem 2014; 62(3): 529-41.
Yadav SS, Singh MK, Singh PK, et al. Traditional knowledge to clinical trials: A review on therapeutic actions of Emblica officinalis. Biomed Pharmacother 2017; 93: 1292-302.
Bhattacharya A, Chatterjee A, Ghosal S, et al. Antioxidant activity of active tannoid principles of Emblica officinalis (amla). Indian J Exp Biol 1999; 37(7): 676-80.
Liu X, Cui C, Zhao M, et al. Identification of phenolics in the fruit of emblica (Phyllanthus emblica L.) and their antioxidant activities. Food Chem 2008; 109(4): 909-15.
Habib ur R, Yasin KA, Choudhary MA, et al. Studies on the chemical constituents of Phyllanthus emblica. Nat Prod Res 2007; 21(9): 775-81.
Nguyen TA, Duong TH, Le Pogam P, et al. Two new triterpenoids from the roots of Phyllanthus emblica. Fitoterapia 2018; 130: 140-4.
Rogowska A,Szakiel A. The role of sterols in plant response to abiotic stress. Phytochem Rev 2020; 19(6): 1525-38.
Hazra B, Sarkar R, Biswas S, et al. Comparative study of the antioxidant and reactive oxygen species scavenging properties in the extracts of the fruits of Terminalia chebula, Terminalia belerica and Emblica officinalis. BMC Complement Altern Med 2010; 10: 20.
Majeed M, Bhat B, Jadhav AN, et al. Ascorbic Acid and Tannins from Emblica officinalis Gaertn. Fruits-A Revisit. J Agric Food Chem 2009; 57(1): 220-5.
Josh JK, Kuttan R, Bhattcharya RK. Effect of Emblica officinalis extract on hepatocarcinogenesis and carcinogen metabolism. J Clin Biochem Nutr 1998; 25: 31-9.
Josh JK, Kuttan G, George J, et al. Antimutagenic and anticarcinogenic activity of Emblica oficinalis Gaertn. J Clin Biochem Nutr 1997; 22: 171-6.
Sharma N, Trikha P, Athar M, et al. In vitro inhibition of carcinogen-induced mutagenicity by Cassia occidentalis and Emblica officinalis. Drug Chem Toxicol 2000; 23(3): 477-84.
Sharma N, Trikha P, Athar M, et al. Inhibitory effect of Emblica officinalis on the in vivo clastogenicity of benzo[a]pyrene and cyclophosphamide in mice. Hum Exp Toxicol 2000; 19(6): 377-84.
Ghosh A, Sharma A, Talukder G. Relative protection given by extract of Phyllanthus emblica fruit and an equivalent amount of vitamin C against a known clastogen--caesium chloride. Food Chem Toxicol 1992; 30(10): 865-9.
Dhir H, Roy AK, Sharma A, et al. Modification of clastogenicity of lead and aluminium in mouse bone marrow cells by dietary ingestion of Phyllanthus emblica fruit extract. Mutat Res 1990; 241(3): 305-12.
Dhir H, Agarwal K, Sharma A, et al. Modifying role of Phyllanthus emblica and ascorbic acid against nickel clastogenicity in mice. Cancer Lett 1991; 59(1): 9-18.
Roy AK, Dhir H,Sharma A. Modification of metal-induced micronuclei formation in mouse bone marrow erythrocytes by Phyllanthus fruit extract and ascorbic acid. Toxicol Lett 1992; 62(1): 9-17.
Banu SM, Selvendiran K, Singh JP, et al. Protective effect of Emblica officinalis ethanolic extract against 7,12-dimethylbenz(a) anthracene (DMBA) induced genotoxicity in Swiss albino mice. Hum Exp Toxicol 2004; 23(11): 527-31.
Giftson Senapathy J, Jayanthi S, Viswanathan P, et al. Effect of gallic acid on xenobiotic metabolizing enzymes in 1,2-dimethyl hydrazine induced colon carcinogenesis in Wistar rats--a chemopreventive approach. Food Chem Toxicol 2011; 49(4): 887-92.
Ferk F, Chakraborty A, Jager W, et al. Potent protection of gallic acid against DNA oxidation: results of human and animal experiments. Mutat Res 2011; 715(1-2): 61-71.
Shruthi S, Bhasker SK. Genoprotective effects of gallic acid against cisplatin induced genotoxicity in bone marrow cells of mice. Toxicol Res (Camb) 2018; 7(5): 951-58.
Ahn D, Putt D, Kresty L, et al. The effects of dietary ellagic acid on rat hepatic and esophageal mucosal cytochromes P450 and phase II enzymes. Carcinogenesis 1996; 17(4): 821-8.
Jose JK, Kuttan G,Kuttan R. Antitumour activity of Emblica officinalis. J Ethnopharmacol 2001; 75(2-3): 65-9.
Yang CJ, Wang CS, Hung JY, et al. Pyrogallol induces G2-M arrest in human lung cancer cells and inhibits tumor growth in an animal model. Lung Cancer 2009; 66(2): 162-8.
Ou TT, Wang CJ, Lee YS, et al. Gallic acid induces G2/M phase cell cycle arrest via regulating 14-3-3beta release from Cdc25C and Chk2 activation in human bladder transitional carcinoma cells. Mol Nutr Food Res 2010; 54(12): 1781-90.
Chen KH, Lin BR, Chien CT, et al. Emblica officinalis Gaertn. Attentuates N-Nitrosodiethyl-amine-induced apoptosis, autophagy, and inflammation in rat livers. J Med Food 2011; 14(7-8): 746-55.
Ngamkitidechakul C, Jaijoy K, Hansakul P, et al. Antitumour effects of Phyllanthus emblica L.: induction of cancer cell apoptosis and inhibition of in vivo tumour promotion and in vitro invasion of human cancer cells. Phytother Res 2010; 24(9): 1405-13.
Sakagami H, Jiang Y, Kusama K, et al. Cytotoxic activity of hydrolyzable tannins against human oral tumor cell lines--a possible mechanism. Phytomedicine 2000; 7(1): 39-47.
Son YO, Lee KY, Kook SH, et al. Selective effects of quercetin on the cell growth and antioxidant defense system in normal versus transformed mouse hepatic cell lines. Eur J Pharmacol 2004; 502(3): 195-204.
Isuzugawa K, Ogihara Y, Inoue M. Different generation of inhibitors against gallic acid-induced apoptosis produces different sensitivity to gallic acid. Biol Pharm Bull 2001; 24(3): 249-53.
Seeram NP, Adams LS, Henning SM, et al. In vitro antiproliferative, apoptotic and antioxidant activities of punicalagin, ellagic acid and a total pomegranate tannin extract are enhanced in combination with other polyphenols as found in pomegranate juice. J Nutr Biochem 2005; 16(6): 360-7.
Phromnoi K, Yodkeeree S, Anuchapreeda S, et al. Inhibition of MMP-3 activity and invasion of the MDA-MB-231 human invasive breast carcinoma cell line by bioflavonoids. Acta Pharmacol Sin 2009; 30(8): 1169-76.
Ho HH, Chang CS, Ho WC, et al. Anti-metastasis effects of gallic acid on gastric cancer cells involves inhibition of NF-kappaB activity and downregulation of PI3K/AKT/small GTPase signals. Food Chem Toxicol 2010; 48(8-9): 2508-16.
Vijayababu MR, Arunkumar A, Kanagaraj P, et al. Quercetin downregulates matrix metalloproteinases 2 and 9 proteins expression in prostate cancer cells (PC-3). Mol Cell Biochem 2006; 287(1-2): 109-16.
ว. ธ. การวิจัยสมุนไพรทางคลินิก. เวชบันทึกศิริราช 2556; 6(1).
Jaijoy K, Soonthornchareonnon N, Lertprasertsuke N, et al. Acute and chronic oral toxicity of standardized water extract from the fruit of Phyllanthus emblica Linn. . Int J Appl Res Nat Prod 2010; 3(1): 48-58.
Sangeetha S, Malay KS, Kavitha R, et al. Formulation and pharmacokinetic determination of gallic acid in emblica officinalis. Int J App Pharm 2017; 9(5).
