Assessment of Some Biochemical Parameters and Dielectric Relaxations in β-Thalassemic Children
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Abstract
Thalassemias are considered as a group of inherited disturbances or blood disorders characterized by the formation of abnormal hemoglobin. β-thalassemia is the most familiar type of thalassemia worldwide and in Egypt. β -thalassemia is classified into three types; minor, intermediate and major. Thalassemia minor resembles anemia with mild iron-deficiency, whilst Thalassemia major is the most severe; patients with the major form need regular blood transfusion stay alive. Patients with the intermediate form show mild to moderate anemia and do not need regular blood transfusion therapy. Therefore, it was thought to be of value to compare the three types on the bases of various biochemical parameters and dielectric properties of blood in the frequency range up to 5 MHz. Sixty children with β-thalassemia were involved in the research. They were divided into three equal groups, according to their thalassemia type, in addition to the same group of control. All children were subjected to thorough clinical examination, and the following blood analyses were performed: hemoglobin electrophoresis, complete blood picture “CBC”, serum ferritin and creatinine, several vital enzymes, total/direct bilirubin, albumin, and other dielectric parameters. Significant differences were found between thalassemia blood and the control, especially in the case of thalassemia major blood. Dielectric relaxations were also detected in thalassemia blood, indicating possible changes in the RBC membranes of thalassemia blood due to possible variations of the surface charges on the RBC membranes and the reduction of glycophorin sialic acid content. Therefore, the present work reveals significant variations between the biochemical and dielectric properties of the three types of thalassemia blood and control blood, and these differences may be of value in the treatment of thalassemia in children.
Keywords: β-thalassemia; antioxidant; CBC; liver enzyme; dielectric; relaxations
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