Efficiency of Low Dose Dopamine on Glomerular Filtration Rate of Dogs with Chronic Renal Failure
Article Sidebar
Published:
Jul 14, 2018
Keywords:
โดปามีน สุนัข การกรองของไต การขับปัสสาวะ
Main Article Content
Abstract
Normally, low dose dopamine is the popular medication used for treatment of the oliguric and anuric condition in dogs. The effect of low dose dopamine is for increase of diuretic potency resulted in increased elimination of waste products and other substances from the body. However, the evidences to support the diuretic potency of dopamine are inconclusive, especially in dogs with chronic renal failure. Objective of this study was to evaluate the effect of 1 µg/kg/min of dopamine on diuretic induction and increase of glomerular filtration rate (GFR). The records of 13 dogs with chronic renal failure admitted to critical care unit, Kasetsart Veterinary Teaching Hospital, Bangkhen were studied. The creatinine clearance, systolic blood pressure and water out to water in ratio from each dog were used to compare during the period of without and with dopamine administration. The generalized linear model with cross-over analysis was used with the commercial statistical software (NCSS 2007®). The results indicated that creatinine clearance during without and with dopamine administration was 0.43 ± 0.25 ml/min and 0.44 ± 0.30 ml/min, respectively (P = 0.9063). Also, systolic blood pressure during without and with dopamine administration was 127.30 ± 20.68 mm. Hg and 129.23 ± 28.71 mm. Hg, respectively (P = 0.7465). Likewise, water out to water in ratio during without and with dopamine administration was 1.01 ± 0.20 and 1.00 ± 0.27, respectively (P = 0.4733). In conclusion, administration of 1 µg/kg/min dopamine had no effect on creatinine clearance, systolic blood pressure and water out to water in ratio. Therefore, dosage of 1 µg/kg/min of dopamine could not increase diuresis and GFR.
Article Details
How to Cite
Srirattanaprateep, K. and Lekcharoensuk, C. (2018) “Efficiency of Low Dose Dopamine on Glomerular Filtration Rate of Dogs with Chronic Renal Failure”, Journal of Mahanakorn Veterinary Medicine, 13(1), pp. 61–75. Available at: https://li01.tci-thaijo.org/index.php/jmvm/article/view/113858 (Accessed: 24 November 2024).
Section
Research Article
References
1. Abay, M.C., Reyes, J.D., Everts, K. and Wisser, J. 2007. Current literature questions the routine use of low-กose dopamine. AANA. J. 75(1): 57-63.
2. Adam, W.R. 1980. Aldosterone and dopamine receptors in the kidney: sites for pharmacologic manipulation of renal function. Kidney Int. 18(5): 623-635.
3. Almy Frederic, S., Christopher Mary, M., King Don, P. and Brown Scott, A. 2002. Evaluation of cystatin C as an endogenous marker of glomerular filtration rate in dogs. J. Vet. Int. Med. 16(1): 45-51.
4. Armstrong, D.K., Dasta, J.F., Reilley, T.E. and Tallman, Jr., R.D. 1986. Effect of haloperidol on dopamine-induced increase in renal bood flow. Drug Intell. Clin. Pharm. 20(7-8): 543-546.
5. Baum, M. and Quigley, R. 1998. Inhibition of proximal convoluted tubule transport by dopamine. Kidney Int. 54(5): 1593-1600.
6. Bellomo, R., Chapman, M., Finfer, S., Hickling, K. and Myburgh, J. 2000. Low-dose dopamine in patients with early renal dysfunction: A placebo-แontrolled randomised trial. Australian and New Zealand Intensive Care Society (Anzics) Clinical Trials Group. Lancet 356(9248): 2139-2143.
7. Bradshaw, E.G., Pleuvry, B.J. and Sharma, H.L. 1980. Effect of droperidol on dopamine-induced increase in effective renal plasma flow in dogs. Br. J. Anaesth. 52(9): 879-883.
8. Braun, J.P., Lefebvre, H.P. and Watson, A.D. 2003. Creatinine in the dog: A review. Vet. Clin. Pathol. 32(4): 162-179.
9. Burton, C.J. and Tomson, C.R. 1999. Can the use of low-dose dopamine for treatment of acute renal failure be justified? Postgrad. Med. J. 75(883): 269-274.
10. Chertow, G.M., Sayegh, M.H., Allgren, R.L. and Lazarus, J.M. 1996. Is the administration of dopamine associated with adverse or favorable outcomes in acute renal failure? American J. Med. 101(1): 49-53.
11. Cobrin, A.R., Blois, S.L., Kruth, S.A., Abrams-Ogg, A.C.G. and Dewey, C. 2013. Biomarkers in the assessment of acute and chronic kidney diseases in the dog and cat. J. Small Anim. Pract. 54(12): 647-655.
12. Denton, M.D., Chertow, G.M. and Brady, H.R. 1996. "Renal-dose" dopamine for the treatment of acute renal failure: Scientific rationale, experimental studies and clinical trials. Kidney Int. 50(1): 4-14.
13. DiBartola, S.P. and Bateman, S. 2012. Fluid, electrolyte, and acid-base disorders in small animal practice. 4thed. Elsevier Saunders. Missouri. 744 p.
14. Faul, F. 2014. G*Power version 3.1.9.2, Universitat kiel, Germany.
15. Finco Delmar, R., Braselton, W.E. and Cooper Tanya, A. 2001. Relationship between ยlasma iohexol clearance and urinary exogenous creatinine clearance in dogs. J. Vet. Inter. Med. 15(4): 368-373.
16. Furukawa, S., Nagashima, Y., Hoshi, K., Hirao, H., Tanaka, R., Maruo, K. and Yamane, Y. 2002. Effects of dopamine infusion on cardiac and renal blood flows in dogs. J. Vet. Med. Sci. 64(1): 41-44.
17. Girbes, A.R., Patten, M.T., McCloskey, B.V., Groeneveld, A.B. and Hoogenberg, K. 2000. The renal and neurohumoral effects of the addition of low-dose dopamine in septic critically ill patients. Intensive Care Med. 26(11): 1685-1689.
18. Heiene, R. and Moe, L. 1998. Pharmacokineatic aspects of measurement of glomerular filtration rate in the dog: A review. J. Vet. Inter. Med. 12(6): 401-414.
19. Hintze, J., 2007. NCSS and GESS. NCSS.LLC. Kaysville, Utah.
20. Horio, M., Imai, E., Yasuda, Y., Hishida, A. and Matsuo, S. 2009. Simple sampling strategy for measuring inulin renal clearance. Clin. Exp. Nephrol. 13(1): 50-54.
21. Jose, P.A., Raymond, J.R., Bates, M.D., Aperia, A., Felder, R.A. and Carey, R.M. 1992. The renal dopamine receptors. J. Am. Soc. Nephrol. 2(8): 1265-1278.
22. Juste, R.N., Moran, L., Hooper, J. and Soni, N. 1998. Dopamine clearance in critically ill patients. Intensive Care Med. 24(11): 1217-1220.
23. Karthik, S. and Lisbon, A. 2006. Low-dose dopamine in the intensive care unit. Semin. Dial. 19(6): 465-471.
24. Kindgen-Milles, D. and Tarnow, J. 1997. [Low dosage dopamine improves kidney function: Current status of knowledge and evaluation of a controversial topic]. Anasthesiol. Intensivmed. Notfallmed. Schmerzther. 32(6): 333-342.
25. Lauschke, A., Teichgraber, U.K., Frei, U. and Eckardt, K.U. 2006. 'Low-dose' dopamine worsens renal perfusion in patients with acute renal failure. Kidney Int. 69(9): 1669-1674.
26. Lokhandwala, M.F. and Hegde, S.S. 1990. Cardiovascular dopamine receptors: Role of renal dopamine and dopamine receptors in sodium excretion. Pharmacol. Toxicol. 66(4): 237-243.
27. Luippold, G., H. Osswald and B. Muhlbauer. 1998. Renal Effects of Exogenous Dopamine: Modulation by Renal Nerves and Dopamine Receptor Antagonists. Naunyn Schmiedebergs Arch Pharmacol 358 (4): 445-451.
28. Lynch, S.K., K.V. Lemley and M.J. Polak. 2003. The Effect of Dopamine on Glomerular Filtration Rate in Normotensive, Oliguric Premature Neonates. Pediatr Nephrol 18 (7): 649-652.
29. Marinosci, G.Z., De Robertis, E., De Benedictis, G. and Piazza, O. 2012. Dopamine use in intensive care: Are we ready to turn it down? Transl. Med. UniSa. 4: 90-94.
30. McCrory, C. and Cunningham, A.J. 1997. Low-dose dopamine: Will there ever be a scientific rationale? Br. J. Anaesth. 78(4): 350-351.
31. Missale, C., Nash, S.R., Robinson, S.W., Jaber, M. and Caron, M.G. 1998. Dopamine receptors: From structure to function. Physiol. Rev. 78(1): 189-225.
32. Miyagawa, Y., Takemura, N. and Hirose, H. 2010. Assessments of factors that affect glomerular filtration rate and indirect markers of renal function in dogs and cats. J. Vet. Med. Sci. 72(9): 1129-1136.
33. Nguyen, L.B., Lievano, G., Radhakrishnan, J., Fornell, L.C., Jacobson, G. and John, E.G. 1999. Renal effects of low to moderate doses of dopamine in newborn piglets. J. Pediatr. Surg. 34(6): 996-999.
34. Olsen, N.V., Olsen, M.H., Bonde, J., Kanstrup, I.L., Plum, I., Strandgaard, S. and Leyssac, P.P. 1997. Dopamine natriuresis in salt-Repleted, water-loaded humans: A dose-response study. Br. J. Clin. Pharmacol. 43(5): 509-520.
35. Plumb, D.C. 2008. Plumb’s Veterinary Drug Handbook. 6thed. Blackwell Publishing. Iowa. 1120 p.
36. Prins, I., Plotz, F.B., Uiterwaal, C.S. and van Vught, H.J. 2001. Low-dose dopamine in neonatal and pediatric intensive care: A systematic review. Intensive Care Med. 27(1): 206-210.
37. Schenarts, P.J., Sagraves, S.G., Bard, M.R., Toschlog, E.A., Goettler, C.E., Newell, M.A. and Rotondo, M.F. 2006. Low-dose dopamine: A physiologically based review. Current Surgery. 63(3): 219-225.
38. Schoeppe, W. 1977. Effects of Dopamine on kidney function. Proc. R. Soc. Med. 70(Suppl 2): 36-42.
39. Sigrist, N.E. 2007. Use of dopamine in acute renal failure. J. Vet. Emerg.cy Critical Care. 17(2): 117-126.
40. Singer, I. and Epstein, M. 1998. Potential of dopamine a-1 agonists in the management of acute renal failure. Am. J. Kidney Dis. 31(5): 743-755.
41. Star, R.A. 1998. Treatment of acute renal failure. Kidney International, 54(6): 1817-1831.
42. Venkataraman, R. and Kellum, J.A. 2007. Prevention of acute renal failure. Chest. 131(1): 300-308.
43. Verderese, M.A., Vianna, P.T., Ganem, E.M. and Vane, L.A. 2003. Renal and cardiovascular effects of dopamine and 7.5% dodium chloride infusion: Experimental study in dogs with water restriction. Rev. Bras. Anestesiol. 53(5): 600-609.
44. Von Hendy-Willson, V.E. and Pressler, B.M. 2011. An overview of glomerular filtration rate testing in dogs and cats. Vet. J. (London, England : 1997). 188(2): 156-165.
45. Yatsu, T., Arai, Y., Takizawa, K., Kasai-Nakagawa, C., Takanashi, M., Uchida, W., Inagaki, O., Tanaka, A. and Takenaka, T. T. 1998. Effect of Ym435, a dopamine Da1 receptor agonist, in a canine model of ischemic acute renal failure. Gen. Pharmacol. 31(5): 803-807.
2. Adam, W.R. 1980. Aldosterone and dopamine receptors in the kidney: sites for pharmacologic manipulation of renal function. Kidney Int. 18(5): 623-635.
3. Almy Frederic, S., Christopher Mary, M., King Don, P. and Brown Scott, A. 2002. Evaluation of cystatin C as an endogenous marker of glomerular filtration rate in dogs. J. Vet. Int. Med. 16(1): 45-51.
4. Armstrong, D.K., Dasta, J.F., Reilley, T.E. and Tallman, Jr., R.D. 1986. Effect of haloperidol on dopamine-induced increase in renal bood flow. Drug Intell. Clin. Pharm. 20(7-8): 543-546.
5. Baum, M. and Quigley, R. 1998. Inhibition of proximal convoluted tubule transport by dopamine. Kidney Int. 54(5): 1593-1600.
6. Bellomo, R., Chapman, M., Finfer, S., Hickling, K. and Myburgh, J. 2000. Low-dose dopamine in patients with early renal dysfunction: A placebo-แontrolled randomised trial. Australian and New Zealand Intensive Care Society (Anzics) Clinical Trials Group. Lancet 356(9248): 2139-2143.
7. Bradshaw, E.G., Pleuvry, B.J. and Sharma, H.L. 1980. Effect of droperidol on dopamine-induced increase in effective renal plasma flow in dogs. Br. J. Anaesth. 52(9): 879-883.
8. Braun, J.P., Lefebvre, H.P. and Watson, A.D. 2003. Creatinine in the dog: A review. Vet. Clin. Pathol. 32(4): 162-179.
9. Burton, C.J. and Tomson, C.R. 1999. Can the use of low-dose dopamine for treatment of acute renal failure be justified? Postgrad. Med. J. 75(883): 269-274.
10. Chertow, G.M., Sayegh, M.H., Allgren, R.L. and Lazarus, J.M. 1996. Is the administration of dopamine associated with adverse or favorable outcomes in acute renal failure? American J. Med. 101(1): 49-53.
11. Cobrin, A.R., Blois, S.L., Kruth, S.A., Abrams-Ogg, A.C.G. and Dewey, C. 2013. Biomarkers in the assessment of acute and chronic kidney diseases in the dog and cat. J. Small Anim. Pract. 54(12): 647-655.
12. Denton, M.D., Chertow, G.M. and Brady, H.R. 1996. "Renal-dose" dopamine for the treatment of acute renal failure: Scientific rationale, experimental studies and clinical trials. Kidney Int. 50(1): 4-14.
13. DiBartola, S.P. and Bateman, S. 2012. Fluid, electrolyte, and acid-base disorders in small animal practice. 4thed. Elsevier Saunders. Missouri. 744 p.
14. Faul, F. 2014. G*Power version 3.1.9.2, Universitat kiel, Germany.
15. Finco Delmar, R., Braselton, W.E. and Cooper Tanya, A. 2001. Relationship between ยlasma iohexol clearance and urinary exogenous creatinine clearance in dogs. J. Vet. Inter. Med. 15(4): 368-373.
16. Furukawa, S., Nagashima, Y., Hoshi, K., Hirao, H., Tanaka, R., Maruo, K. and Yamane, Y. 2002. Effects of dopamine infusion on cardiac and renal blood flows in dogs. J. Vet. Med. Sci. 64(1): 41-44.
17. Girbes, A.R., Patten, M.T., McCloskey, B.V., Groeneveld, A.B. and Hoogenberg, K. 2000. The renal and neurohumoral effects of the addition of low-dose dopamine in septic critically ill patients. Intensive Care Med. 26(11): 1685-1689.
18. Heiene, R. and Moe, L. 1998. Pharmacokineatic aspects of measurement of glomerular filtration rate in the dog: A review. J. Vet. Inter. Med. 12(6): 401-414.
19. Hintze, J., 2007. NCSS and GESS. NCSS.LLC. Kaysville, Utah.
20. Horio, M., Imai, E., Yasuda, Y., Hishida, A. and Matsuo, S. 2009. Simple sampling strategy for measuring inulin renal clearance. Clin. Exp. Nephrol. 13(1): 50-54.
21. Jose, P.A., Raymond, J.R., Bates, M.D., Aperia, A., Felder, R.A. and Carey, R.M. 1992. The renal dopamine receptors. J. Am. Soc. Nephrol. 2(8): 1265-1278.
22. Juste, R.N., Moran, L., Hooper, J. and Soni, N. 1998. Dopamine clearance in critically ill patients. Intensive Care Med. 24(11): 1217-1220.
23. Karthik, S. and Lisbon, A. 2006. Low-dose dopamine in the intensive care unit. Semin. Dial. 19(6): 465-471.
24. Kindgen-Milles, D. and Tarnow, J. 1997. [Low dosage dopamine improves kidney function: Current status of knowledge and evaluation of a controversial topic]. Anasthesiol. Intensivmed. Notfallmed. Schmerzther. 32(6): 333-342.
25. Lauschke, A., Teichgraber, U.K., Frei, U. and Eckardt, K.U. 2006. 'Low-dose' dopamine worsens renal perfusion in patients with acute renal failure. Kidney Int. 69(9): 1669-1674.
26. Lokhandwala, M.F. and Hegde, S.S. 1990. Cardiovascular dopamine receptors: Role of renal dopamine and dopamine receptors in sodium excretion. Pharmacol. Toxicol. 66(4): 237-243.
27. Luippold, G., H. Osswald and B. Muhlbauer. 1998. Renal Effects of Exogenous Dopamine: Modulation by Renal Nerves and Dopamine Receptor Antagonists. Naunyn Schmiedebergs Arch Pharmacol 358 (4): 445-451.
28. Lynch, S.K., K.V. Lemley and M.J. Polak. 2003. The Effect of Dopamine on Glomerular Filtration Rate in Normotensive, Oliguric Premature Neonates. Pediatr Nephrol 18 (7): 649-652.
29. Marinosci, G.Z., De Robertis, E., De Benedictis, G. and Piazza, O. 2012. Dopamine use in intensive care: Are we ready to turn it down? Transl. Med. UniSa. 4: 90-94.
30. McCrory, C. and Cunningham, A.J. 1997. Low-dose dopamine: Will there ever be a scientific rationale? Br. J. Anaesth. 78(4): 350-351.
31. Missale, C., Nash, S.R., Robinson, S.W., Jaber, M. and Caron, M.G. 1998. Dopamine receptors: From structure to function. Physiol. Rev. 78(1): 189-225.
32. Miyagawa, Y., Takemura, N. and Hirose, H. 2010. Assessments of factors that affect glomerular filtration rate and indirect markers of renal function in dogs and cats. J. Vet. Med. Sci. 72(9): 1129-1136.
33. Nguyen, L.B., Lievano, G., Radhakrishnan, J., Fornell, L.C., Jacobson, G. and John, E.G. 1999. Renal effects of low to moderate doses of dopamine in newborn piglets. J. Pediatr. Surg. 34(6): 996-999.
34. Olsen, N.V., Olsen, M.H., Bonde, J., Kanstrup, I.L., Plum, I., Strandgaard, S. and Leyssac, P.P. 1997. Dopamine natriuresis in salt-Repleted, water-loaded humans: A dose-response study. Br. J. Clin. Pharmacol. 43(5): 509-520.
35. Plumb, D.C. 2008. Plumb’s Veterinary Drug Handbook. 6thed. Blackwell Publishing. Iowa. 1120 p.
36. Prins, I., Plotz, F.B., Uiterwaal, C.S. and van Vught, H.J. 2001. Low-dose dopamine in neonatal and pediatric intensive care: A systematic review. Intensive Care Med. 27(1): 206-210.
37. Schenarts, P.J., Sagraves, S.G., Bard, M.R., Toschlog, E.A., Goettler, C.E., Newell, M.A. and Rotondo, M.F. 2006. Low-dose dopamine: A physiologically based review. Current Surgery. 63(3): 219-225.
38. Schoeppe, W. 1977. Effects of Dopamine on kidney function. Proc. R. Soc. Med. 70(Suppl 2): 36-42.
39. Sigrist, N.E. 2007. Use of dopamine in acute renal failure. J. Vet. Emerg.cy Critical Care. 17(2): 117-126.
40. Singer, I. and Epstein, M. 1998. Potential of dopamine a-1 agonists in the management of acute renal failure. Am. J. Kidney Dis. 31(5): 743-755.
41. Star, R.A. 1998. Treatment of acute renal failure. Kidney International, 54(6): 1817-1831.
42. Venkataraman, R. and Kellum, J.A. 2007. Prevention of acute renal failure. Chest. 131(1): 300-308.
43. Verderese, M.A., Vianna, P.T., Ganem, E.M. and Vane, L.A. 2003. Renal and cardiovascular effects of dopamine and 7.5% dodium chloride infusion: Experimental study in dogs with water restriction. Rev. Bras. Anestesiol. 53(5): 600-609.
44. Von Hendy-Willson, V.E. and Pressler, B.M. 2011. An overview of glomerular filtration rate testing in dogs and cats. Vet. J. (London, England : 1997). 188(2): 156-165.
45. Yatsu, T., Arai, Y., Takizawa, K., Kasai-Nakagawa, C., Takanashi, M., Uchida, W., Inagaki, O., Tanaka, A. and Takenaka, T. T. 1998. Effect of Ym435, a dopamine Da1 receptor agonist, in a canine model of ischemic acute renal failure. Gen. Pharmacol. 31(5): 803-807.