Oral Malignant Melanoma of Right Mandibular Gingiva in Dog: Case Report

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Puttipong Thermtong
Poosuda Poodee
Wanatchaporn Kunchornwichai
Sarobol Plianprasert
Titaree Laoharatchatathanin

Abstract

A 12-year-old neuter male Mixed dog, presented with a mass of right mandibular gingiva for 2 month (size 4x5 centimeter). Previously, that used to have surgery for oral malignant melanoma, out from the right mandibular area approximately 1 year. Overall results from the general physical examination were normal unless enlargement of right submandibular lymph node, left submandibular lymph node and right popliteal lymph node. The histopathological diagnosis was oral malignant melanoma and metastasis into right submandibular lymph node. The dog was prescribed with the total right hemimandibulectomy and postoperative chemotherapy which included Lomustine (CCNU) for a 25 week treatment duration. The results after chemotherapy showed the lymph nodes decreased in size and revealed no recurrence in nearby areas. A thoracic radiograph and an abdominal ultrasound did not reveal evidence of metastasis when compared to pre chemotherapy.

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Case Report

References

Almela, R.M. and Ansón, A. 2019. A Review of Immunotherapeutic Strategies in Canine Malignant Melanoma. Vet. Sci. 6(1): 15.

Bergman, P.J. 2007. Canine Oral Melanoma. Clin. Tech. Small. Anim. Pract. 22(2): 55-60.

Dobson, J.M., Hohenhaus, A.E. and Peaston, A.E. 2008. Cancer chemotherapy. In: Small Animal Clinical Pharmacology. 1st ed. WB Saunders. Philadelphia. 330-366p.

Fossum, T.W., Cho, J., Dewey, C.W., Hayashi, K., Huntingford, J.L., MacPhail, C.M., Quandt, J.E., Radlinsky, M.G., Schulz, K.S., Willard, M.D. and Yu-Speight, A. 2019. Surgery of the digestive system. In: Small animal surgery. 5th edition. Elsevier, Inc. Philadelphia. 337p.

Heading, K.L., Brockley, L.K. and Bennett, P.F. 2011. CCNU (lomustine) toxicity in dogs: a retrospective study (2002-07). Aust. Vet. J. 89(4): 109-116.

Kawabe, M., Mori, T., Ito, Y., Murakami, M., Sakai, H., Yanai, T. and Maruo, K. 2015. Outcomes of dogs undergoing radiotherapy for treatment of oral malignant melanoma: 111 cases. J. Am. Vet. Med. Assoc. 15(10): 1146-1153.

Kristal, O., Rassnick, K.M., Gliatto, J.M., Northrup, N.C., Chretin, J.D., Collister, M.K., Cotter, S.M. and Moore, A.S. 2004. Hepatotoxicity associated with CCNU (lomustine) chemotherapy in dogs. J. Vet. Intern. Med. 18(1): 75–80.

Locatelli, C., Filippin-Monteiro, F.B. and Creczynski-Pasa, T.B. 2013. Current Therapies and New Pharmacologic Target for Metastatic Melanoma. In: Recent Advances in the Biology, Therapy and Management of Melanoma. Available form: https://www.intechopen.com/chapters/42746, 16 August 2021.

MacEwen, E.G., Patnaik, A.K., Harvey, H.J., Hayes, A.A. and Matus, R. 1986. Canine oral melanoma: comparison of surgery versus surgery plus Corynebacterium parvum. Cancer. Invest. 4(5): 397-402.

Maekawa, N., Konnai, S., Takagi, S., Kagawa, Y., Okagawa, T., Nishimori, A., Ikebuchi, R., Izumi, Y., Deguchi, T., Naka¬jima, C., Kato, Y., Yamamoto, K., Uemura, H., Suzuki, Y., Murata, S. and Ohashi, K. 2017. A canine chimeric monoclonal antibody targeting PD-L1 and its clinical efficacy in canine oral malignant melanoma or undifferentiated sarcoma. Scientific Reports. 7(1): 8951.

Nishiya, A.T., Massoco, C.O., Felizzola, C.R., Perlmann, E., Batschinski, K., Tedardi, M.V., Garcia, J.S. Mendoca, P.P., Teixeira, T.F. and Dagli, M.L.Z. 2016. Comparative Aspects of Canine Melanoma. Vet. Sci. 3(1): 1-22.

Owen, L.N., 1980. TNM Classification of Tumors in Domestic Animals. 1st edition. World Health Organization; Geneva.23-24p.

Papich, M.G. 2016. Saunders Handbook of Veterinary Drugs. 4th ed. WB Saunders. St. Louis. 456-457p.

Ramos-Vara, J.A., Beissenherz, M.E., Miller, M.A., Johnson, G.C., Pace, L.W., Fard, A. and Kottler, S.J. 2000. Retrospective Study of 338 Canine Oral Melanomas with Clinical, Histologic, and Immunohistochemical Review of 129 Cases. Vet. Pathol. 37(6): 597-608.

Spilo, T., Liu, L. and Gerson, S. 2000. New cytotoxic agents for the treatment of metastatic malignant melanoma: temozolomide and related alkylating agents in combination with guanine analogues to abrogate drug resistance. Forum (Genova). 10(3): 274-285.

Smedley, R.C., Lamoureux, J., Sledge, D.G., and Kiupe, M. 2011. Immunohistochemical diagnosis of canine oral amelanotic melanocytic neoplasms. Vet. Pathol. 48(1): 32–40.

Tuohy J.L., Selmic L.E., Worley D.R., Ehrhart N.P. and Withrow, S.J. 2014. Outcome following curative-intent surgery for oral melanoma in dogs: 70 cases (1998–2011) J. Am. Vet. Med. Assoc. 1; 245(11): 1266–1273.

Vail, D.M., Thamm, D.H. and Liptak, J.M. 2020. Withrow and MacEwen’s small animal clinical oncology. 6th ed. W.B. Saunders. St. Louis. 367-431p.

Verganti, S., Berlato, D., Blackwood, L., Amores-Fuster, I., Polton, G.A., Elders, R., Doyle, R., Taylor, A. and Murphy, S. 2017. Use of Oncept melanoma vaccine in 69canine oral malignant melanomas in the UK. J. Small Anim. Prac. 58(1): 10-16.

Williams, L.E. and Packer, R.A. 2003. Association between lymph node size and metastasis in dogs with oral malignant melanoma: 100 cases (1987-2001). J. Am. Vet. Med. Assoc. 222(9): 1234-1236.