Effects of Moringa OleiferaLeaf Extract on the Acetylcholinesterase and Monoamine Oxidase Activities in Rat Brains with Streptozotocin-InducedDiabetesandSciatic Nerve Constriction

  • Napatr Sriraksa Division of Physiology, School of Medical Sciences, University of Phayao
Keywords: acetylcholinesterase, diabetes mellitus, monoamine oxidase, Moringa oleifera

Abstract

Cognitive decline in diabetes is related to hyperglycemia-induced cerebral metabolism of neurotransmitters that play a role in cognitive function. This study aimed to determine the effect of Moringa oleifera (M. oleifera) leaf extract on the activities of acetylcholinesterase (AChE) and monoamine oxidase (MAO) in diabetic rat brains with a sciatic nerve constriction. Type-I diabetes was induced in young adult male Wistar rats (180-220 g) with a single injection of streptozotocin (STZ) at a dose of 65 mg/kg BW (i.p.). The diabetic rats were further subjected to a right sciatic nerve constriction. Then, rats were randomly assigned to three different doses of orally administered M. oleifera leaf extract (100, 200 and 300 mg/kg BW) for 21 days. The cerebral cortex, hippocampus, and striatum were collected to determine the activities of AChE and MAO. The results showed that M. oleifera leaf extract significantly decreased the activity of AChE and MAO in the studied brain regions.

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Published
2019-12-27
How to Cite
1.
Sriraksa N. Effects of Moringa OleiferaLeaf Extract on the Acetylcholinesterase and Monoamine Oxidase Activities in Rat Brains with Streptozotocin-InducedDiabetesandSciatic Nerve Constriction. Naresaun Phayao J [Internet]. 2019Dec.27 [cited 2020Mar.29];12(3):13-2. Available from: https://li01.tci-thaijo.org/index.php/journalup/article/view/188720
Section
Research articles