Antihypertensive effects of Ma-kiang fruit extract on hypertensive rats
Keywords:
Ma-kiang fruit extract, hypertension, Wistar rat, L-NAMEAbstract
The aim of this study was to investigate the acute and chronic effects of Ma-kiang fruit extract on blood pressure in L-NAME induced hypertensive rats. We found significant reduction of blood pressure in a dose-dependent manner through intravenous injection of the extract (20, 40 and 60 mg/kg). Moreover, the chronic oral administration of the extract (500 mg/kg/day) for 6 weeks in hypertensive rats showed the significant attenuation of hypertension, and did not significantly decreased heart rate.
References
2. Taddei S, Virdis A, Mattei P, Ghiadoni L, Sudano I, Salvetti A. Defective L-arginine-nitric oxide pathway in offspring of essential hypertensive patients. Circulation. 1996;94:1298–1303.
3. Shin W, Cuong TD, Lee JH, Min B, Jeon BH, Lim HK, et al. Arginase inhibition by ethylacetate extract of Caesalpinia sappan lignum contributes to activation of endothelial nitric oxide synthase. Korean J Physiol Pharmacol. 2011;15:123–128.
4. Jacques-Silva MC, Nogueira CW, Broch LC, Flores EM, Rocha JB. Diphenyl diselenide and ascorbic acid changes deposition of selenium and ascorbic acid in liver and brain of mice. Pharmacol Toxicol. 2001;88:119–125.
5. Moncada S, Palmer RM, Higgs EA. Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol Rev. 1991;43:109–142.
6. Radomski MW, Palmer RM, Moncada S. Characterization of the L-arginine:nitric oxide pathway in human platelets. Br J Pharmacol. 1990;101:325–328.
7. Cho EJ, Park MS, Kim SS, Kang G, Choi S, Lee YR, et al. Vasorelaxing activity of ulmus davidiana ethanol extracts in rats: activation of endothelial nitric oxide synthase. Korean J Physiol Pharmacol. 2011;15:339–344.
8. Bernátová I, Pechánová O, Kristek F. Mechanism of structural remodelling of the rat aorta during long-term NG-nitro-L-arginine methyl ester treatment. Jpn J Pharmacol. 1999;81:99–106.
9. Fink J, Fan NY, Rosenfeld L, Stier CT Jr. Contribution of endothelin to the acute pressor response of L-NAME in stroke-prone spontaneously hypertensive rats. J Cardiovasc Pharmacol. 1998;31:618–622.
10. Nakanishi K, Mattson DL, Cowley AW Jr. Role of renal medullary blood flow in the development of L-NAME hypertension in rats. Am J Physiol. 1995;268:R317–R323.
11. Ribeiro MO, Antunes E, de Nucci G, Lovisolo SM, Zatz R. Chronic inhibition of nitric oxide synthesis: A new model of arterial hypertension. Hypertension. 1992;20:298–303.
12. Rees DD, Palmer RM, Moncada S. Role of endothelium-derived nitric oxide in the regulation of blood pressure. Proc Natl Acad Sci U S A. 1989;86:3375–3378.
13. Rowley K, Walker KZ, Cohen J, Jenkins AJ, O'Neal D, Su Q, et al. Inflammation and vascular endothelial activation in an Aboriginal population: relationships to coronary disease risk factors and nutritional markers. Med J Aust. 2003;178:495–500.
14. Rao AV. Lycopene, tomatoes, and the prevention of coronary heart disease. Exp Biol Med (Maywood). 2002;227:908–913.
15. Weisburger JH. Lycopene and tomato products in health promotion. Exp Biol Med (Maywood). 2002;227:924–927.
16. Sukprasansap M, Chanvorachote P, Tencimnao T. Cleistocalyx nervosum var. paniala berry fruit protects neurotoxicity against endoplasmic reticulum stress-induced apoptosis. Food Chem Toxicol. 2017;103:279-288.
17. Tabassum N, Ahmed F. Role of natural herbs in the treatment of hypertension. Pharmacogn Rev. 2011;5(9):30-40.
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