Effect of Boesenbergia rotunda L. extract on sensory neuron after sciatic nerve lesion in rat
Keywords:
Boesenbergia rotundaL., sciatic nerve lesion, dorsal root ganglia, neurite outgrowthAbstract
The study was investigated the effect of B. rotunda rhizomes extract with respect to neurite outgrowth in vitro and number of sensory neurons after sciatic nerve injury in vivo. Neurite outgrowth from neuron cultures of dorsal root ganglia was evaluated by examination of morphological changes using immunohistochemistry for β-tubulin-III. We observed a statistically nonsignificant trend toward promote neurite outgrowth of sensory neurons of B. rotunda treated group at concentration of 1 µl/ml. To study the effect of B. rotunda on morphological changes of dorsal root ganglia, adult male Wistar rats were treated with the B. rotunda extract for 28 days after sciatic nerve injury at the dose of 200 mg/kg body weight. Overall sensory neuron number in dorsal root ganglia was determined by counting in hematoxylin and eosin sections. The sensory neuron number of B. rotunda treated group was significantly higher than in control and vehicle groups at the injury side. However, there were no changes in sensory neuron number of contralateral side. Following sciatic nerve crush, motor coordination was observed on the rotarod treadmill (acceleratingmode). This was a statistically nonsignificant trend toward improved motor coordination.
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