Role of Cordycepin from Cordyceps militaris on lower hyperuricemia
Keywords:
Cordycepin, Cordyceps militaris, HyperuricemiaAbstract
Previously, scientific evidence reported that cordycepin (3'-deoxyadenosine), an important bioactive compound from Cordyceps militaris, has pharmaceutical affects for antimicrobial, immunomodulatory, anti-hyperglycemia, anti-tumor, anti-metastatic, fertility enhancer and inhibited melanogenesis activities. However, there are no report on anti-hyperuricemia which is the major risk factors for the development of gout and uric acid nephrolithiasis. Moreover, it effect on high mortality rates of hypertension, hyperlipidemia and atherosclerosis patients. Thus, this review article provided the theoretical guidance the role of Cordycepin from Cordyceps militaris on lower hyperuricemia actions in mice by decreasing serum uric acid and exhibited the strongest xanthine oxidase enzyme inhibitory activity on uric acid synthesis in vitro which will be beneficial for further development of therapeutic strategies for hyperuricemia treatment.
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