Proteomic analysis of frontal cortex proteins in a rat model of depression induced by dexamethasone

Authors

  • Siriluk Veerasakul School of Public Health, Walailak University
  • Korakod Bandasak Faculty of Medical Science, Naresuan University
  • Plaiyfah Janthueng Faculty of Medical Science, Naresuan University
  • Sittiruk Roytrakul National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency
  • Samur Thanoi Faculty of Medical Science, Naresuan University
  • Sutisa Nudmamud-Thanoi Faculty of Medical Science, Naresuan University

Keywords:

Proteomics, Depression, Frontal cortex, Dexamethasone

Abstract

This study was designed to characterize the identified proteins in the frontal cortex of a rat model of depression induced by dexamethasone using proteomic technique.  Identified proteins were analyzed according to the biological function. The identified proteins were categorized in the response to the cellular process, metabolic process, and others including cell-cell signaling, which are associated with the brain functions.  Results showed that uniquely expressed proteins in control and depressive groups reveal the function of monoamine, glutamate and GABA receptors and appear to be a part of the protein transporter, the regulating protein of cell communication and synapse. In addition, a decrease of the co-expressed proteins was found in the depressive group when compared to the control group. These proteins are associated with the function of the dopamine neurotransmitter system. The results of this study suggest that the associated proteins in synaptic transmission, particularly neurotransmitter receptors, regulating proteins of cell communication and synapse play an important role in the pathophysiology of depression. Furthermore, the identified proteins in this study may be used as a biological marker in the study of frontal cortex function to further clarify the mechanism for depression. That may lead to appropriate treatment.

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Published

2021-04-30

How to Cite

1.
Veerasakul S, Bandasak K, Janthueng P, Roytrakul S, Thanoi S, Nudmamud-Thanoi S. Proteomic analysis of frontal cortex proteins in a rat model of depression induced by dexamethasone. Health Sci Tech Rev [Internet]. 2021 Apr. 30 [cited 2024 Mar. 29];14(1):3-15. Available from: https://li01.tci-thaijo.org/index.php/journalup/article/view/247102

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Research articles