Efficacy of pomegranate peel extracts in prostate cancer cells

Authors

  • Piyanut Khanema Faculty of Science, Mahasarakham University
  • Jinnawat Manasathien Faculty of Science and Technology, Nakhon Ratchasima Rajabhat University

Keywords:

Pomegranate, Phenolic content, Radical scavenging activity, Prostate cancer

Abstract

          Prostate cancer is one of the most common cancers in males and trouble to treat. Also, the treatment takes high cost and has side effects on patients sometimes. Therefore, medicinal plants are a suitable choice for the treatment of prostate cancer. The objective of this study was to evaluate the total phenolic content of pomegranate peel extracts and their antioxidant activity. In addition, the growth inhibitory effect, the morphological changes, and the nuclear condensation of PC-3 prostate cancer cells were required to study for determining the potential of peel extracts. The result found that the total phenolic content of peel ethanolic extract (PE/e) was higher than peel water extract (PE/w) (428.03 > 362.47 µg GAE/mg, respectively). Corresponding to an ability of median ABTS radical scavenging concentration (EC50), PE/e (129.20 µg/mL) was grateful over than PE/w (151.27 µg/mL) by the ability was similarly to catechin (128.91 µg/mL) but less than epigallocatechin-3-gallate (71.05 µg/mL). Catechin and epigallocatechin-3-gallate both are positive control. For inhibiting the growth of PC-3 cancer cells though median inhibitory concentration (IC50), it found that PE/e (455.63 µg/mL) was more potent than PE/w (685.98 µg/mL) by both extracts could inhibit cancer cells better than catechin (897.12 µg/mL) but lower than epigallocatechin-3-gallate (180.42 µg/mL). Moreover, both extracts could induce morphological changes and nuclear condensation of PC-3 cells. In conclusion, the pomegranate peel extracts had high phenolic contents and the great potential of antioxidation. Also, the peel extracts had a dominant effect on PC-3 cells antiproliferation.

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Published

2022-04-30

How to Cite

1.
Khanema P, Manasathien J. Efficacy of pomegranate peel extracts in prostate cancer cells. Health Sci Tech Rev [Internet]. 2022 Apr. 30 [cited 2024 Mar. 29];15(1):34-49. Available from: https://li01.tci-thaijo.org/index.php/journalup/article/view/249490

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Section

Research articles